JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis.
Segments are fundamental units in animal development which are made of distinct cell lineages separated by boundaries. Although boundaries show limited plasticity during their formation for sharpening, cell lineages make compartments that become tightly restricted as development goes on. Here, we ch...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-06-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2882433?pdf=render |
| _version_ | 1819149225700622336 |
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| author | Melanie Gettings Fanny Serman Raphaël Rousset Patrizia Bagnerini Luis Almeida Stéphane Noselli |
| author_facet | Melanie Gettings Fanny Serman Raphaël Rousset Patrizia Bagnerini Luis Almeida Stéphane Noselli |
| author_sort | Melanie Gettings |
| collection | DOAJ |
| description | Segments are fundamental units in animal development which are made of distinct cell lineages separated by boundaries. Although boundaries show limited plasticity during their formation for sharpening, cell lineages make compartments that become tightly restricted as development goes on. Here, we characterize a unique case of breaking of the segment boundary in late drosophila embryos. During dorsal closure, specific cells from anterior compartments cross the segment boundary and enter the adjacent posterior compartments. This cell mixing behaviour is driven by an anterior-to-posterior reprogramming mechanism involving de novo expression of the homeodomain protein Engrailed. Mixing is accompanied by stereotyped local cell intercalation, converting the segment boundary into a relaxation compartment important for tension-release during morphogenesis. This process of lineage switching and cell remodelling is controlled by JNK signalling. Our results reveal plasticity of segment boundaries during late morphogenesis and a role for JNK-dependent developmental reprogramming in this process. |
| first_indexed | 2024-12-22T13:58:14Z |
| format | Article |
| id | doaj.art-e7f8d1688bac495db0aaf9bd43dc444c |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-22T13:58:14Z |
| publishDate | 2010-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-e7f8d1688bac495db0aaf9bd43dc444c2022-12-21T18:23:29ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852010-06-0186e100039010.1371/journal.pbio.1000390JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis.Melanie GettingsFanny SermanRaphaël RoussetPatrizia BagneriniLuis AlmeidaStéphane NoselliSegments are fundamental units in animal development which are made of distinct cell lineages separated by boundaries. Although boundaries show limited plasticity during their formation for sharpening, cell lineages make compartments that become tightly restricted as development goes on. Here, we characterize a unique case of breaking of the segment boundary in late drosophila embryos. During dorsal closure, specific cells from anterior compartments cross the segment boundary and enter the adjacent posterior compartments. This cell mixing behaviour is driven by an anterior-to-posterior reprogramming mechanism involving de novo expression of the homeodomain protein Engrailed. Mixing is accompanied by stereotyped local cell intercalation, converting the segment boundary into a relaxation compartment important for tension-release during morphogenesis. This process of lineage switching and cell remodelling is controlled by JNK signalling. Our results reveal plasticity of segment boundaries during late morphogenesis and a role for JNK-dependent developmental reprogramming in this process.http://europepmc.org/articles/PMC2882433?pdf=render |
| spellingShingle | Melanie Gettings Fanny Serman Raphaël Rousset Patrizia Bagnerini Luis Almeida Stéphane Noselli JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis. PLoS Biology |
| title | JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis. |
| title_full | JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis. |
| title_fullStr | JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis. |
| title_full_unstemmed | JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis. |
| title_short | JNK signalling controls remodelling of the segment boundary through cell reprogramming during Drosophila morphogenesis. |
| title_sort | jnk signalling controls remodelling of the segment boundary through cell reprogramming during drosophila morphogenesis |
| url | http://europepmc.org/articles/PMC2882433?pdf=render |
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