Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins
Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum neurotoxin (BoNT), becoming standard of care in 198...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/12/4/269 |
| _version_ | 1827718265537822720 |
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| author | Travis J.W. Hassell David Charles |
| author_facet | Travis J.W. Hassell David Charles |
| author_sort | Travis J.W. Hassell |
| collection | DOAJ |
| description | Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum neurotoxin (BoNT), becoming standard of care in 1989. This comprehensive review utilized MEDLINE and PubMed and provides an overview of the history of these focal dystonias, BoNT, and the use of toxin to treat them. We present the levels of clinical evidence for each toxin for both, focal dystonias and offer guidance for muscle and site selection as well as dosing. |
| first_indexed | 2024-03-10T20:18:51Z |
| format | Article |
| id | doaj.art-e7f9de3de89b45128546d345f21cca40 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T20:18:51Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-e7f9de3de89b45128546d345f21cca402023-11-19T22:21:20ZengMDPI AGToxins2072-66512020-04-0112426910.3390/toxins12040269Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum ToxinsTravis J.W. Hassell0David Charles1Department of Neurology, Vanderbilt University Medical Center, 1161 21st Avenue South, Suite A-1106 MCN, Nashville, TN 37232, USADepartment of Neurology, Vanderbilt University Medical Center, 1161 21st Avenue South, Suite A-1106 MCN, Nashville, TN 37232, USABlepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum neurotoxin (BoNT), becoming standard of care in 1989. This comprehensive review utilized MEDLINE and PubMed and provides an overview of the history of these focal dystonias, BoNT, and the use of toxin to treat them. We present the levels of clinical evidence for each toxin for both, focal dystonias and offer guidance for muscle and site selection as well as dosing.https://www.mdpi.com/2072-6651/12/4/269blepharospasmoromandibular dystoniaMeige syndromebotulinum toxinOnabotulinumtoxinAAbobotulinumtoxinA |
| spellingShingle | Travis J.W. Hassell David Charles Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins Toxins blepharospasm oromandibular dystonia Meige syndrome botulinum toxin OnabotulinumtoxinA AbobotulinumtoxinA |
| title | Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins |
| title_full | Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins |
| title_fullStr | Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins |
| title_full_unstemmed | Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins |
| title_short | Treatment of Blepharospasm and Oromandibular Dystonia with Botulinum Toxins |
| title_sort | treatment of blepharospasm and oromandibular dystonia with botulinum toxins |
| topic | blepharospasm oromandibular dystonia Meige syndrome botulinum toxin OnabotulinumtoxinA AbobotulinumtoxinA |
| url | https://www.mdpi.com/2072-6651/12/4/269 |
| work_keys_str_mv | AT travisjwhassell treatmentofblepharospasmandoromandibulardystoniawithbotulinumtoxins AT davidcharles treatmentofblepharospasmandoromandibulardystoniawithbotulinumtoxins |