The Protective Effect of Rosmarinic Acid against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts
Parabens, which are widely used in food, medicines and cosmetics, have a harmful effect on human health. People are most exposed to parabens transdermally by using cosmetic products containing these preservatives. The purpose of this study was to estimate the influence of parabens (methylparaben—MP...
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/5/1282 |
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| author | Natalia Matwiejczuk Anna Galicka Ilona Zaręba Małgorzata M. Brzóska |
| author_facet | Natalia Matwiejczuk Anna Galicka Ilona Zaręba Małgorzata M. Brzóska |
| author_sort | Natalia Matwiejczuk |
| collection | DOAJ |
| description | Parabens, which are widely used in food, medicines and cosmetics, have a harmful effect on human health. People are most exposed to parabens transdermally by using cosmetic products containing these preservatives. The purpose of this study was to estimate the influence of parabens (methylparaben—MP and propylparaben—PP) on the metabolism of collagen in the human skin fibroblasts and above all, to assess whether rosmarinic acid (RA—50, 100, or 150 μM) can protect these cells from the adverse effects of parabens (0.001% MP and 0.0003% PP, 0.003% MP and 0.001% PP, and 0.01% MP and 0.003% PP). The possible mechanisms of RA action were estimated as well. Parabens decreased the expression of collagen type I and III at mRNA and protein levels, while RA (depending on the concentration) provided partial or total protection against these changes. The effective protection against the adverse effects of parabens on cell viability and proliferation was also provided by RA. The beneficial impact of RA on collagen and the fibroblasts resulted from an independent action of this compound and its interaction with parabens. This study allows us to conclude that this polyphenolic compound may protect from unfavorable health outcomes caused by lifetime human exposure to parabens contained in cosmetic products. |
| first_indexed | 2024-03-10T20:06:57Z |
| format | Article |
| id | doaj.art-e7fad054163e4c88bc27bae05086cabe |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:06:57Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e7fad054163e4c88bc27bae05086cabe2023-11-19T23:13:32ZengMDPI AGNutrients2072-66432020-05-01125128210.3390/nu12051282The Protective Effect of Rosmarinic Acid against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin FibroblastsNatalia Matwiejczuk0Anna Galicka1Ilona Zaręba2Małgorzata M. Brzóska3Department of Medical Chemistry, Medical University of Bialystok, Adama Mickiewicza 2A street, 15-222 Bialystok, PolandDepartment of Medical Chemistry, Medical University of Bialystok, Adama Mickiewicza 2A street, 15-222 Bialystok, PolandDepartment of Medicinal Chemistry, Medical University of Bialystok, Adama Mickiewicza 2D street, 15-222 Bialystok, PolandDepartment of Toxicology, Medical University of Bialystok, Adama Mickiewicza 2C street, 15-222 Bialystok, PolandParabens, which are widely used in food, medicines and cosmetics, have a harmful effect on human health. People are most exposed to parabens transdermally by using cosmetic products containing these preservatives. The purpose of this study was to estimate the influence of parabens (methylparaben—MP and propylparaben—PP) on the metabolism of collagen in the human skin fibroblasts and above all, to assess whether rosmarinic acid (RA—50, 100, or 150 μM) can protect these cells from the adverse effects of parabens (0.001% MP and 0.0003% PP, 0.003% MP and 0.001% PP, and 0.01% MP and 0.003% PP). The possible mechanisms of RA action were estimated as well. Parabens decreased the expression of collagen type I and III at mRNA and protein levels, while RA (depending on the concentration) provided partial or total protection against these changes. The effective protection against the adverse effects of parabens on cell viability and proliferation was also provided by RA. The beneficial impact of RA on collagen and the fibroblasts resulted from an independent action of this compound and its interaction with parabens. This study allows us to conclude that this polyphenolic compound may protect from unfavorable health outcomes caused by lifetime human exposure to parabens contained in cosmetic products.https://www.mdpi.com/2072-6643/12/5/1282rosmarinic acidmethylparabenpropylparabencollagenERK1/2MMP |
| spellingShingle | Natalia Matwiejczuk Anna Galicka Ilona Zaręba Małgorzata M. Brzóska The Protective Effect of Rosmarinic Acid against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts Nutrients rosmarinic acid methylparaben propylparaben collagen ERK1/2 MMP |
| title | The Protective Effect of Rosmarinic Acid against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts |
| title_full | The Protective Effect of Rosmarinic Acid against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts |
| title_fullStr | The Protective Effect of Rosmarinic Acid against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts |
| title_full_unstemmed | The Protective Effect of Rosmarinic Acid against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts |
| title_short | The Protective Effect of Rosmarinic Acid against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts |
| title_sort | protective effect of rosmarinic acid against unfavorable influence of methylparaben and propylparaben on collagen in human skin fibroblasts |
| topic | rosmarinic acid methylparaben propylparaben collagen ERK1/2 MMP |
| url | https://www.mdpi.com/2072-6643/12/5/1282 |
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