Niraparib restrains prostate cancer cell proliferation and metastasis and tumor growth in mice by regulating the lncRNA MEG3/miR-181-5p/GATA6 pathway

Niraparib restrains prostate cancer cell proliferation and metastasis and tumor growth in mice by regulating the lncRNA MEG3/miR-181-5p/GATA6 pathway

Background Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), have gained approval for treating patients with castration-resistant prostate cancer (CRPC). Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), plays a role in inhibiting tumorigenesis through regulating DNA repair g...

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Bibliographic Details
Main Authors: Ji Cheng, Yi Sun, Huacai Zhao, Wei Ren, Dan Gao, Zhigang Wang, Wei Lv, Qingchuan Dong
Format: Article
Language:English
Published: PeerJ Inc. 2023-11-01
Series:PeerJ
Subjects:
PCa
Niraparib
PRAPi
LncRNA MEG3
MiR-181-5p
GATA6
Online Access:https://peerj.com/articles/16314.pdf

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