Design and preparation of a novel colon-targeted tablet of hydrocortisone
ABSTRACT The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2017-04-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100601&lng=en&tlng=en |
| _version_ | 1818756629813788672 |
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| author | Yachao Ren Lei Jiang Shuman Yang Sainan Gao Hui Yu Jie Hu Dandan Hu Wenbin Mao Haisheng Peng Yulong Zhou |
| author_facet | Yachao Ren Lei Jiang Shuman Yang Sainan Gao Hui Yu Jie Hu Dandan Hu Wenbin Mao Haisheng Peng Yulong Zhou |
| author_sort | Yachao Ren |
| collection | DOAJ |
| description | ABSTRACT The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit- and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system. |
| first_indexed | 2024-12-18T05:58:05Z |
| format | Article |
| id | doaj.art-e7fcad7385e2430980584f6cebf44515 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-18T05:58:05Z |
| publishDate | 2017-04-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-e7fcad7385e2430980584f6cebf445152022-12-21T21:18:44ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902017-04-0153110.1590/s2175-97902017000115009S1984-82502017000100601Design and preparation of a novel colon-targeted tablet of hydrocortisoneYachao RenLei JiangShuman YangSainan GaoHui YuJie HuDandan HuWenbin MaoHaisheng PengYulong ZhouABSTRACT The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit- and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100601&lng=en&tlng=enChitosan/evaluationChistosan/evaluation/gelatin complex filmDrugs/administrationDrugs/delivery system/Colon-targetingTablets/bilayer-coated |
| spellingShingle | Yachao Ren Lei Jiang Shuman Yang Sainan Gao Hui Yu Jie Hu Dandan Hu Wenbin Mao Haisheng Peng Yulong Zhou Design and preparation of a novel colon-targeted tablet of hydrocortisone Brazilian Journal of Pharmaceutical Sciences Chitosan/evaluation Chistosan/evaluation/gelatin complex film Drugs/administration Drugs/delivery system/Colon-targeting Tablets/bilayer-coated |
| title | Design and preparation of a novel colon-targeted tablet of hydrocortisone |
| title_full | Design and preparation of a novel colon-targeted tablet of hydrocortisone |
| title_fullStr | Design and preparation of a novel colon-targeted tablet of hydrocortisone |
| title_full_unstemmed | Design and preparation of a novel colon-targeted tablet of hydrocortisone |
| title_short | Design and preparation of a novel colon-targeted tablet of hydrocortisone |
| title_sort | design and preparation of a novel colon targeted tablet of hydrocortisone |
| topic | Chitosan/evaluation Chistosan/evaluation/gelatin complex film Drugs/administration Drugs/delivery system/Colon-targeting Tablets/bilayer-coated |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100601&lng=en&tlng=en |
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