Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease
Abstract Imprecise vowels represent a common deficit associated with hypokinetic dysarthria resulting from a reduced articulatory range of motion in Parkinson’s disease (PD). It is not yet unknown whether the vowel articulation impairment is already evident in the prodromal stages of synucleinopathy...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-022-00407-7 |
| _version_ | 1827775907227500544 |
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| author | Dominik Skrabal Jan Rusz Michal Novotny Karel Sonka Evzen Ruzicka Petr Dusek Tereza Tykalova |
| author_facet | Dominik Skrabal Jan Rusz Michal Novotny Karel Sonka Evzen Ruzicka Petr Dusek Tereza Tykalova |
| author_sort | Dominik Skrabal |
| collection | DOAJ |
| description | Abstract Imprecise vowels represent a common deficit associated with hypokinetic dysarthria resulting from a reduced articulatory range of motion in Parkinson’s disease (PD). It is not yet unknown whether the vowel articulation impairment is already evident in the prodromal stages of synucleinopathy. We aimed to assess whether vowel articulation abnormalities are present in isolated rapid eye movement sleep behaviour disorder (iRBD) and early-stage PD. A total of 180 male participants, including 60 iRBD, 60 de-novo PD and 60 age-matched healthy controls performed reading of a standardized passage. The first and second formant frequencies of the corner vowels /a/, /i/, and /u/ extracted from predefined words, were utilized to construct articulatory-acoustic measures of Vowel Space Area (VSA) and Vowel Articulation Index (VAI). Compared to controls, VSA was smaller in both iRBD (p = 0.01) and PD (p = 0.001) while VAI was lower only in PD (p = 0.002). iRBD subgroup with abnormal olfactory function had smaller VSA compared to iRBD subgroup with preserved olfactory function (p = 0.02). In PD patients, the extent of bradykinesia and rigidity correlated with VSA (r = −0.33, p = 0.01), while no correlation between axial gait symptoms or tremor and vowel articulation was detected. Vowel articulation impairment represents an early prodromal symptom in the disease process of synucleinopathy. Acoustic assessment of vowel articulation may provide a surrogate marker of synucleinopathy in scenarios where a single robust feature to monitor the dysarthria progression is needed. |
| first_indexed | 2024-03-11T13:56:40Z |
| format | Article |
| id | doaj.art-e7fecb6a1bd6485f936955322ae4a94b |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T13:56:40Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-e7fecb6a1bd6485f936955322ae4a94b2023-11-02T06:40:05ZengNature Portfolionpj Parkinson's Disease2373-80572022-10-01811710.1038/s41531-022-00407-7Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s diseaseDominik Skrabal0Jan Rusz1Michal Novotny2Karel Sonka3Evzen Ruzicka4Petr Dusek5Tereza Tykalova6Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University HospitalDepartment of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University HospitalDepartment of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in PragueDepartment of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University HospitalDepartment of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University HospitalDepartment of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University HospitalDepartment of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in PragueAbstract Imprecise vowels represent a common deficit associated with hypokinetic dysarthria resulting from a reduced articulatory range of motion in Parkinson’s disease (PD). It is not yet unknown whether the vowel articulation impairment is already evident in the prodromal stages of synucleinopathy. We aimed to assess whether vowel articulation abnormalities are present in isolated rapid eye movement sleep behaviour disorder (iRBD) and early-stage PD. A total of 180 male participants, including 60 iRBD, 60 de-novo PD and 60 age-matched healthy controls performed reading of a standardized passage. The first and second formant frequencies of the corner vowels /a/, /i/, and /u/ extracted from predefined words, were utilized to construct articulatory-acoustic measures of Vowel Space Area (VSA) and Vowel Articulation Index (VAI). Compared to controls, VSA was smaller in both iRBD (p = 0.01) and PD (p = 0.001) while VAI was lower only in PD (p = 0.002). iRBD subgroup with abnormal olfactory function had smaller VSA compared to iRBD subgroup with preserved olfactory function (p = 0.02). In PD patients, the extent of bradykinesia and rigidity correlated with VSA (r = −0.33, p = 0.01), while no correlation between axial gait symptoms or tremor and vowel articulation was detected. Vowel articulation impairment represents an early prodromal symptom in the disease process of synucleinopathy. Acoustic assessment of vowel articulation may provide a surrogate marker of synucleinopathy in scenarios where a single robust feature to monitor the dysarthria progression is needed.https://doi.org/10.1038/s41531-022-00407-7 |
| spellingShingle | Dominik Skrabal Jan Rusz Michal Novotny Karel Sonka Evzen Ruzicka Petr Dusek Tereza Tykalova Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease npj Parkinson's Disease |
| title | Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease |
| title_full | Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease |
| title_fullStr | Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease |
| title_full_unstemmed | Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease |
| title_short | Articulatory undershoot of vowels in isolated REM sleep behavior disorder and early Parkinson’s disease |
| title_sort | articulatory undershoot of vowels in isolated rem sleep behavior disorder and early parkinson s disease |
| url | https://doi.org/10.1038/s41531-022-00407-7 |
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