The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics
The functions of specific lipids in autophagosome biogenesis are not entirely clear. Here, the authors show that the ER protein GRAMD1C, a cholesterol transport protein, suppresses autophagy initiation and has roles in mitochondrial cholesterol homeostasis and respiration.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33933-2 |
| _version_ | 1797985994033594368 |
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| author | Matthew Yoke Wui Ng Chara Charsou Ana Lapao Sakshi Singh Laura Trachsel-Moncho Sebastian W. Schultz Sigve Nakken Michael J. Munson Anne Simonsen |
| author_facet | Matthew Yoke Wui Ng Chara Charsou Ana Lapao Sakshi Singh Laura Trachsel-Moncho Sebastian W. Schultz Sigve Nakken Michael J. Munson Anne Simonsen |
| author_sort | Matthew Yoke Wui Ng |
| collection | DOAJ |
| description | The functions of specific lipids in autophagosome biogenesis are not entirely clear. Here, the authors show that the ER protein GRAMD1C, a cholesterol transport protein, suppresses autophagy initiation and has roles in mitochondrial cholesterol homeostasis and respiration. |
| first_indexed | 2024-04-11T07:25:52Z |
| format | Article |
| id | doaj.art-e7fede4d4b1c4ef589afdf61c6e3f288 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T07:25:52Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e7fede4d4b1c4ef589afdf61c6e3f2882022-12-22T04:37:04ZengNature PortfolioNature Communications2041-17232022-10-0113111910.1038/s41467-022-33933-2The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergeticsMatthew Yoke Wui Ng0Chara Charsou1Ana Lapao2Sakshi Singh3Laura Trachsel-Moncho4Sebastian W. Schultz5Sigve Nakken6Michael J. Munson7Anne Simonsen8Department of Molecular Medicine, Institute of Basic Medical Sciences, University of OsloDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of OsloDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of OsloDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of OsloDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of OsloCentre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of OsloCentre for Cancer Cell Reprogramming, Institute of Clinical Medicine, University of OsloDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of OsloDepartment of Molecular Medicine, Institute of Basic Medical Sciences, University of OsloThe functions of specific lipids in autophagosome biogenesis are not entirely clear. Here, the authors show that the ER protein GRAMD1C, a cholesterol transport protein, suppresses autophagy initiation and has roles in mitochondrial cholesterol homeostasis and respiration.https://doi.org/10.1038/s41467-022-33933-2 |
| spellingShingle | Matthew Yoke Wui Ng Chara Charsou Ana Lapao Sakshi Singh Laura Trachsel-Moncho Sebastian W. Schultz Sigve Nakken Michael J. Munson Anne Simonsen The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics Nature Communications |
| title | The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics |
| title_full | The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics |
| title_fullStr | The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics |
| title_full_unstemmed | The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics |
| title_short | The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics |
| title_sort | cholesterol transport protein gramd1c regulates autophagy initiation and mitochondrial bioenergetics |
| url | https://doi.org/10.1038/s41467-022-33933-2 |
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