Electrochemical and in vitro biological behaviors of a Ti-Mo-Fe alloy specifically designed for stent applications
There is a deep interest in developing new Ni-free Ti-based alloys to replace 316 L stainless steel and Co-Cr alloys for endovascular stent application, mainly because the release of Ni can generate toxicity and allergenicity. Interactions of Ti alloy biomaterials with bone cells and tissues have be...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Biomaterials and Biosystems |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666534423000053 |
| _version_ | 1827940244029177856 |
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| author | Carolina Catanio Bortolan Francesco Copes Masoud Shekargoftar Vinicius de Oliveira Fidelis Sales Carlo Paternoster Leonardo Contri Campanelli Nicolas Giguère Diego Mantovani |
| author_facet | Carolina Catanio Bortolan Francesco Copes Masoud Shekargoftar Vinicius de Oliveira Fidelis Sales Carlo Paternoster Leonardo Contri Campanelli Nicolas Giguère Diego Mantovani |
| author_sort | Carolina Catanio Bortolan |
| collection | DOAJ |
| description | There is a deep interest in developing new Ni-free Ti-based alloys to replace 316 L stainless steel and Co-Cr alloys for endovascular stent application, mainly because the release of Ni can generate toxicity and allergenicity. Interactions of Ti alloy biomaterials with bone cells and tissues have been widely investigated and reported, while interactions with vascular cells and tissues, such as endothelial cells (ECs) and smooth muscle cells (SMCs), are scarce. Therefore, this study focused on the relationship among the surface finishing features, corrosion behavior and in vitro biological performances regarding human ECs, SMCs and blood of a newly developed Ti-8Mo-2Fe (TMF) alloy, specifically designed for balloon-expandable stent applications. The alloy performances were compared to those of 316 L and pure Ti, prepared with the same surface finishing techniques, which are mechanical polishing and electropolishing. Surface properties were investigated by scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle (CA) and x-ray photoelectron spectroscopy (XPS). The corrosion behavior was assessed with potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) tests in phosphate buffered saline (PBS) solution. No significant differences were observed regarding the corrosion rate measured with PDP analyses, which was of the order of 2 × 10−4 mm/y for all the studied materials. Moreover, similarly to pure Ti, TMF exhibited an advantage over 316 L for biomedical applications, namely remarkable resistance to pitting corrosion up to high potentials. The results evidenced a good cytocompatibility and hemocompatibility, making this group of alloy a potential candidate for cardiovascular implants. In fact, both ECs and SMCs proliferated on TMF surfaces showing a 7-day viability similar to that of pure Ti. Regarding hemocompatibility, TMF did not cause hemolysis, and blood coagulation was delayed on its surface in comparison to pure Ti. When compared to 316 L, TMF showed similar hemocompatibility. |
| first_indexed | 2024-03-13T09:06:20Z |
| format | Article |
| id | doaj.art-e8015cbf939747df891c9fbd2c15c642 |
| institution | Directory Open Access Journal |
| issn | 2666-5344 |
| language | English |
| last_indexed | 2024-03-13T09:06:20Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomaterials and Biosystems |
| spelling | doaj.art-e8015cbf939747df891c9fbd2c15c6422023-05-28T04:09:17ZengElsevierBiomaterials and Biosystems2666-53442023-06-0110100076Electrochemical and in vitro biological behaviors of a Ti-Mo-Fe alloy specifically designed for stent applicationsCarolina Catanio Bortolan0Francesco Copes1Masoud Shekargoftar2Vinicius de Oliveira Fidelis Sales3Carlo Paternoster4Leonardo Contri Campanelli5Nicolas Giguère6Diego Mantovani7Laboratory for Biomaterials and Bioengineering (LBB). Canada Research Chair Tier I for the Innovation in Surgery, Department of Mining, Metallurgy, and Materials Engineering & Regenerative Medicine, CHU de Quebec Research Center, Laval University, Quebec City G1V 0A6, CanadaLaboratory for Biomaterials and Bioengineering (LBB). Canada Research Chair Tier I for the Innovation in Surgery, Department of Mining, Metallurgy, and Materials Engineering & Regenerative Medicine, CHU de Quebec Research Center, Laval University, Quebec City G1V 0A6, CanadaLaboratory for Biomaterials and Bioengineering (LBB). Canada Research Chair Tier I for the Innovation in Surgery, Department of Mining, Metallurgy, and Materials Engineering & Regenerative Medicine, CHU de Quebec Research Center, Laval University, Quebec City G1V 0A6, CanadaLaboratory for Biomaterials and Bioengineering (LBB). Canada Research Chair Tier I for the Innovation in Surgery, Department of Mining, Metallurgy, and Materials Engineering & Regenerative Medicine, CHU de Quebec Research Center, Laval University, Quebec City G1V 0A6, CanadaLaboratory for Biomaterials and Bioengineering (LBB). Canada Research Chair Tier I for the Innovation in Surgery, Department of Mining, Metallurgy, and Materials Engineering & Regenerative Medicine, CHU de Quebec Research Center, Laval University, Quebec City G1V 0A6, CanadaInstitute of Science and Technology (ICT), Federal University of São Paulo – UNIFESP, São José dos Campos 12231-280, BrazilQuebec Metallurgy Center (CMQ), Trois-Rivières G9A 5E1, CanadaLaboratory for Biomaterials and Bioengineering (LBB). Canada Research Chair Tier I for the Innovation in Surgery, Department of Mining, Metallurgy, and Materials Engineering & Regenerative Medicine, CHU de Quebec Research Center, Laval University, Quebec City G1V 0A6, Canada; Corresponding author at: Laboratory for Biomaterials and Bioengineering, Canada Research Chair Tier 1 in Biomaterials and Bioengineering for the Innovation in Surgery, Department Mining, Metallurgy, and Materials Engineering, Laval University, Pavillon Adrien-Pouliot, Room 1745-E, Canada.There is a deep interest in developing new Ni-free Ti-based alloys to replace 316 L stainless steel and Co-Cr alloys for endovascular stent application, mainly because the release of Ni can generate toxicity and allergenicity. Interactions of Ti alloy biomaterials with bone cells and tissues have been widely investigated and reported, while interactions with vascular cells and tissues, such as endothelial cells (ECs) and smooth muscle cells (SMCs), are scarce. Therefore, this study focused on the relationship among the surface finishing features, corrosion behavior and in vitro biological performances regarding human ECs, SMCs and blood of a newly developed Ti-8Mo-2Fe (TMF) alloy, specifically designed for balloon-expandable stent applications. The alloy performances were compared to those of 316 L and pure Ti, prepared with the same surface finishing techniques, which are mechanical polishing and electropolishing. Surface properties were investigated by scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle (CA) and x-ray photoelectron spectroscopy (XPS). The corrosion behavior was assessed with potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) tests in phosphate buffered saline (PBS) solution. No significant differences were observed regarding the corrosion rate measured with PDP analyses, which was of the order of 2 × 10−4 mm/y for all the studied materials. Moreover, similarly to pure Ti, TMF exhibited an advantage over 316 L for biomedical applications, namely remarkable resistance to pitting corrosion up to high potentials. The results evidenced a good cytocompatibility and hemocompatibility, making this group of alloy a potential candidate for cardiovascular implants. In fact, both ECs and SMCs proliferated on TMF surfaces showing a 7-day viability similar to that of pure Ti. Regarding hemocompatibility, TMF did not cause hemolysis, and blood coagulation was delayed on its surface in comparison to pure Ti. When compared to 316 L, TMF showed similar hemocompatibility.http://www.sciencedirect.com/science/article/pii/S2666534423000053Titanium alloyStentsCorrosionHemocompatibilityEndothelial cellsSmooth muscle cells |
| spellingShingle | Carolina Catanio Bortolan Francesco Copes Masoud Shekargoftar Vinicius de Oliveira Fidelis Sales Carlo Paternoster Leonardo Contri Campanelli Nicolas Giguère Diego Mantovani Electrochemical and in vitro biological behaviors of a Ti-Mo-Fe alloy specifically designed for stent applications Biomaterials and Biosystems Titanium alloy Stents Corrosion Hemocompatibility Endothelial cells Smooth muscle cells |
| title | Electrochemical and in vitro biological behaviors of a Ti-Mo-Fe alloy specifically designed for stent applications |
| title_full | Electrochemical and in vitro biological behaviors of a Ti-Mo-Fe alloy specifically designed for stent applications |
| title_fullStr | Electrochemical and in vitro biological behaviors of a Ti-Mo-Fe alloy specifically designed for stent applications |
| title_full_unstemmed | Electrochemical and in vitro biological behaviors of a Ti-Mo-Fe alloy specifically designed for stent applications |
| title_short | Electrochemical and in vitro biological behaviors of a Ti-Mo-Fe alloy specifically designed for stent applications |
| title_sort | electrochemical and in vitro biological behaviors of a ti mo fe alloy specifically designed for stent applications |
| topic | Titanium alloy Stents Corrosion Hemocompatibility Endothelial cells Smooth muscle cells |
| url | http://www.sciencedirect.com/science/article/pii/S2666534423000053 |
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