Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma
Background: Sarcopenia affects hepatocellular carcinoma (HCC) prognosis. Sarcopenia can be assessed by using skeletal muscle index (SMI), measured on transverse CT images at the third lumbar vertebra (L3). HCC staging consists of liver function assessment and Eastern Cooperative Oncology Group perfo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Interna Publishing
2022-05-01
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| Series: | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
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| Online Access: | https://www.ina-jghe.com/index.php/jghe/article/view/822 |
| _version_ | 1797810529981431808 |
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| author | Hendra Koncoro Irsan Hasan C Rinaldi Lesmana Humala Prika Aditama Thariqah Salamah Aulia Rizka Edy Rizal Wahyudi Hamzah Shatri |
| author_facet | Hendra Koncoro Irsan Hasan C Rinaldi Lesmana Humala Prika Aditama Thariqah Salamah Aulia Rizka Edy Rizal Wahyudi Hamzah Shatri |
| author_sort | Hendra Koncoro |
| collection | DOAJ |
| description | Background: Sarcopenia affects hepatocellular carcinoma (HCC) prognosis. Sarcopenia can be assessed by using skeletal muscle index (SMI), measured on transverse CT images at the third lumbar vertebra (L3). HCC staging consists of liver function assessment and Eastern Cooperative Oncology Group performance status (ECOG-PS). ECOG-PS can reflect physical function. This study was aimed to describe the proportion of sarcopenia among adults, using Japan Society of Hepatology criteria and explore association between sarcopenia and poor performance status.
Method: The study was conducted in a tertiary hospital during January – October 2021. SMI were evaluated using computed tomography images of L3 in 85 HCC patients. Clinical, laboratory and body composition data were analyzed using bivariate analysis. Logistic regression was performed to obtain an independent association between ECOG-PS and sarcopenic status of HCC patients.
Results: Eighty-five HCC patients (median age, 52 years) were analyzed. Sarcopenia was observed in 49,4% of HCC patients. On multivariate binary regression analysis, a poor ECOG-PS remained independently associated with sarcopenia in HCC (adjusted OR = 4.169 (CI 95% = 1.504-11,555), p 0,006).
Conclusion: Sarcopenia has high proportion in HCC patients. There were strong association between ECOG-PS and sarcopenia in HC. |
| first_indexed | 2024-03-13T07:10:16Z |
| format | Article |
| id | doaj.art-e801e68422494d4399c9289e29547028 |
| institution | Directory Open Access Journal |
| issn | 1411-4801 2302-8181 |
| language | English |
| last_indexed | 2024-03-13T07:10:16Z |
| publishDate | 2022-05-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy |
| spelling | doaj.art-e801e68422494d4399c9289e295470282023-06-06T04:45:36ZengInterna PublishingThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy1411-48012302-81812022-05-01231172310.24871/231202217-23779Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular CarcinomaHendra Koncoro0Irsan Hasan1C Rinaldi Lesmana2Humala Prika Aditama3Thariqah Salamah4Aulia Rizka5Edy Rizal Wahyudi6Hamzah Shatri7Department of Internal Medicine, Sint Carolus Hospital, JakartaDivision of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, JakartaDivision of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National General Hospital, JakartaDivision of Musculoskeletal, Department of Radiology, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, JakartaDivision of Musculoskeletal, Department of Radiology, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, JakartaDivision of Geriatrics, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, JakartaDivision of Geriatrics, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, JakartaDivision of Psychosomatic and Palliative Medicine, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, JakartaBackground: Sarcopenia affects hepatocellular carcinoma (HCC) prognosis. Sarcopenia can be assessed by using skeletal muscle index (SMI), measured on transverse CT images at the third lumbar vertebra (L3). HCC staging consists of liver function assessment and Eastern Cooperative Oncology Group performance status (ECOG-PS). ECOG-PS can reflect physical function. This study was aimed to describe the proportion of sarcopenia among adults, using Japan Society of Hepatology criteria and explore association between sarcopenia and poor performance status. Method: The study was conducted in a tertiary hospital during January – October 2021. SMI were evaluated using computed tomography images of L3 in 85 HCC patients. Clinical, laboratory and body composition data were analyzed using bivariate analysis. Logistic regression was performed to obtain an independent association between ECOG-PS and sarcopenic status of HCC patients. Results: Eighty-five HCC patients (median age, 52 years) were analyzed. Sarcopenia was observed in 49,4% of HCC patients. On multivariate binary regression analysis, a poor ECOG-PS remained independently associated with sarcopenia in HCC (adjusted OR = 4.169 (CI 95% = 1.504-11,555), p 0,006). Conclusion: Sarcopenia has high proportion in HCC patients. There were strong association between ECOG-PS and sarcopenia in HC.https://www.ina-jghe.com/index.php/jghe/article/view/822sarcopeniahepatocellular carcinomal3-smiecogindonesia |
| spellingShingle | Hendra Koncoro Irsan Hasan C Rinaldi Lesmana Humala Prika Aditama Thariqah Salamah Aulia Rizka Edy Rizal Wahyudi Hamzah Shatri Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy sarcopenia hepatocellular carcinoma l3-smi ecog indonesia |
| title | Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma |
| title_full | Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma |
| title_fullStr | Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma |
| title_full_unstemmed | Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma |
| title_short | Sarcopenia are Associated with Poor Performance Status in Indonesian Patients with Hepatocellular Carcinoma |
| title_sort | sarcopenia are associated with poor performance status in indonesian patients with hepatocellular carcinoma |
| topic | sarcopenia hepatocellular carcinoma l3-smi ecog indonesia |
| url | https://www.ina-jghe.com/index.php/jghe/article/view/822 |
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