An Up-to-Date Review of Natural Nanoparticles for Cancer Management
Cancer represents one of the leading causes of morbidity and mortality worldwide, imposing an urgent need to develop more efficient treatment alternatives. In this respect, much attention has been drawn from conventional cancer treatments to more modern approaches, such as the use of nanotechnology....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/1/18 |
| _version_ | 1797491239426195456 |
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| author | Daniel Ion Adelina-Gabriela Niculescu Dan Nicolae Păduraru Octavian Andronic Florentina Mușat Alexandru Mihai Grumezescu Alexandra Bolocan |
| author_facet | Daniel Ion Adelina-Gabriela Niculescu Dan Nicolae Păduraru Octavian Andronic Florentina Mușat Alexandru Mihai Grumezescu Alexandra Bolocan |
| author_sort | Daniel Ion |
| collection | DOAJ |
| description | Cancer represents one of the leading causes of morbidity and mortality worldwide, imposing an urgent need to develop more efficient treatment alternatives. In this respect, much attention has been drawn from conventional cancer treatments to more modern approaches, such as the use of nanotechnology. Extensive research has been done for designing innovative nanoparticles able to specifically target tumor cells and ensure the controlled release of anticancer agents. To avoid the potential toxicity of synthetic materials, natural nanoparticles started to attract increasing scientific interest. In this context, this paper aims to review the most important natural nanoparticles used as active ingredients (e.g., polyphenols, polysaccharides, proteins, and sterol-like compounds) or as carriers (e.g., proteins, polysaccharides, viral nanoparticles, and exosomes) of various anticancer moieties, focusing on their recent applications in treating diverse malignancies. |
| first_indexed | 2024-03-10T00:44:36Z |
| format | Article |
| id | doaj.art-e80378e0eb3f48da821296c6e5ca1549 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T00:44:36Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e80378e0eb3f48da821296c6e5ca15492023-11-23T15:02:31ZengMDPI AGPharmaceutics1999-49232021-12-011411810.3390/pharmaceutics14010018An Up-to-Date Review of Natural Nanoparticles for Cancer ManagementDaniel Ion0Adelina-Gabriela Niculescu1Dan Nicolae Păduraru2Octavian Andronic3Florentina Mușat4Alexandru Mihai Grumezescu5Alexandra Bolocan6General Surgery Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaGeneral Surgery Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaGeneral Surgery Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaGeneral Surgery Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, RomaniaGeneral Surgery Department, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, RomaniaCancer represents one of the leading causes of morbidity and mortality worldwide, imposing an urgent need to develop more efficient treatment alternatives. In this respect, much attention has been drawn from conventional cancer treatments to more modern approaches, such as the use of nanotechnology. Extensive research has been done for designing innovative nanoparticles able to specifically target tumor cells and ensure the controlled release of anticancer agents. To avoid the potential toxicity of synthetic materials, natural nanoparticles started to attract increasing scientific interest. In this context, this paper aims to review the most important natural nanoparticles used as active ingredients (e.g., polyphenols, polysaccharides, proteins, and sterol-like compounds) or as carriers (e.g., proteins, polysaccharides, viral nanoparticles, and exosomes) of various anticancer moieties, focusing on their recent applications in treating diverse malignancies.https://www.mdpi.com/1999-4923/14/1/18natural nanoparticlesnatural anticancer compoundsnatural cancer therapiesnovel cancer treatment alternativesnatural nanocarrierschemotherapeutic agents targeted delivery |
| spellingShingle | Daniel Ion Adelina-Gabriela Niculescu Dan Nicolae Păduraru Octavian Andronic Florentina Mușat Alexandru Mihai Grumezescu Alexandra Bolocan An Up-to-Date Review of Natural Nanoparticles for Cancer Management Pharmaceutics natural nanoparticles natural anticancer compounds natural cancer therapies novel cancer treatment alternatives natural nanocarriers chemotherapeutic agents targeted delivery |
| title | An Up-to-Date Review of Natural Nanoparticles for Cancer Management |
| title_full | An Up-to-Date Review of Natural Nanoparticles for Cancer Management |
| title_fullStr | An Up-to-Date Review of Natural Nanoparticles for Cancer Management |
| title_full_unstemmed | An Up-to-Date Review of Natural Nanoparticles for Cancer Management |
| title_short | An Up-to-Date Review of Natural Nanoparticles for Cancer Management |
| title_sort | up to date review of natural nanoparticles for cancer management |
| topic | natural nanoparticles natural anticancer compounds natural cancer therapies novel cancer treatment alternatives natural nanocarriers chemotherapeutic agents targeted delivery |
| url | https://www.mdpi.com/1999-4923/14/1/18 |
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