High Concentration of Serum Soluble Fas in Patients with Head and Neck Carcinoma: A Comparative Study Before and After Surgical Removal of Tumor
Background:Alternative splicing of the Fas transcript can produce a naturalsecreted isoform of this molecule. Some cancer cells can also produce soluble Fas (sFas)which may have suppressive effects on the immune system's anti-tumor response.Elevated concentrations of sFas have been detected in...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2010-01-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/5/14 |
| _version_ | 1818114557771513856 |
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| author | Seyed Basir Hashemi Mohammad Javad Fattahi Mansooreh Jaberipour Mojtaba Habibagahi Mahmood Shariati |
| author_facet | Seyed Basir Hashemi Mohammad Javad Fattahi Mansooreh Jaberipour Mojtaba Habibagahi Mahmood Shariati |
| author_sort | Seyed Basir Hashemi |
| collection | DOAJ |
| description | Background:Alternative splicing of the Fas transcript can produce a naturalsecreted isoform of this molecule. Some cancer cells can also produce soluble Fas (sFas)which may have suppressive effects on the immune system's anti-tumor response.Elevated concentrations of sFas have been detected in the sera of patients with differentmalignancies. Materials and Methods:The concentrations of sFas in sera of patients with headand neck carcinoma (HNC, n=98) and healthy individuals (n=30) were measured bySandwich ELISAand compared to values obtained six months after surgical removalof the tumor (n=48). Data were correlated with different clinical findings of thepatients. Results:sFas concentrations in the sera of HNC patients were found to besignificantly higher in patients with different tumor stages. sFas concentration did notcorrelate with age or tumor invasiveness, however a higher concentration of sFas wasfound in the sera of patients who had higher tumor grades. Surgical removal oftumors in patients resulted in a substantial decrease in sFas concentration.Conclusion:The initial rise in sFas concentration in the sera of HNC patients andits consequent decrease could be regarded as a sign of tumor suppressive mechanisms.Additional studies are needed to fully elucidate this mechanism however these findingsmight show the prospective use of such biomarkers to determine disease prognosis andeven immunotherapeutic applications. |
| first_indexed | 2024-12-11T03:52:38Z |
| format | Article |
| id | doaj.art-e8077b507f984174942ceec1fd971a74 |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-12-11T03:52:38Z |
| publishDate | 2010-01-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-e8077b507f984174942ceec1fd971a742022-12-22T01:21:52ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872010-01-01112126High Concentration of Serum Soluble Fas in Patients with Head and Neck Carcinoma: A Comparative Study Before and After Surgical Removal of TumorSeyed Basir HashemiMohammad Javad FattahiMansooreh JaberipourMojtaba HabibagahiMahmood ShariatiBackground:Alternative splicing of the Fas transcript can produce a naturalsecreted isoform of this molecule. Some cancer cells can also produce soluble Fas (sFas)which may have suppressive effects on the immune system's anti-tumor response.Elevated concentrations of sFas have been detected in the sera of patients with differentmalignancies. Materials and Methods:The concentrations of sFas in sera of patients with headand neck carcinoma (HNC, n=98) and healthy individuals (n=30) were measured bySandwich ELISAand compared to values obtained six months after surgical removalof the tumor (n=48). Data were correlated with different clinical findings of thepatients. Results:sFas concentrations in the sera of HNC patients were found to besignificantly higher in patients with different tumor stages. sFas concentration did notcorrelate with age or tumor invasiveness, however a higher concentration of sFas wasfound in the sera of patients who had higher tumor grades. Surgical removal oftumors in patients resulted in a substantial decrease in sFas concentration.Conclusion:The initial rise in sFas concentration in the sera of HNC patients andits consequent decrease could be regarded as a sign of tumor suppressive mechanisms.Additional studies are needed to fully elucidate this mechanism however these findingsmight show the prospective use of such biomarkers to determine disease prognosis andeven immunotherapeutic applications.http://mejc.sums.ac.ir/index.php/mejc/article/view/5/14FasHead and neck carcinomaSoluble Fas |
| spellingShingle | Seyed Basir Hashemi Mohammad Javad Fattahi Mansooreh Jaberipour Mojtaba Habibagahi Mahmood Shariati High Concentration of Serum Soluble Fas in Patients with Head and Neck Carcinoma: A Comparative Study Before and After Surgical Removal of Tumor Middle East Journal of Cancer Fas Head and neck carcinoma Soluble Fas |
| title | High Concentration of Serum Soluble Fas in Patients with Head and Neck Carcinoma: A Comparative Study Before and After Surgical Removal of Tumor |
| title_full | High Concentration of Serum Soluble Fas in Patients with Head and Neck Carcinoma: A Comparative Study Before and After Surgical Removal of Tumor |
| title_fullStr | High Concentration of Serum Soluble Fas in Patients with Head and Neck Carcinoma: A Comparative Study Before and After Surgical Removal of Tumor |
| title_full_unstemmed | High Concentration of Serum Soluble Fas in Patients with Head and Neck Carcinoma: A Comparative Study Before and After Surgical Removal of Tumor |
| title_short | High Concentration of Serum Soluble Fas in Patients with Head and Neck Carcinoma: A Comparative Study Before and After Surgical Removal of Tumor |
| title_sort | high concentration of serum soluble fas in patients with head and neck carcinoma a comparative study before and after surgical removal of tumor |
| topic | Fas Head and neck carcinoma Soluble Fas |
| url | http://mejc.sums.ac.ir/index.php/mejc/article/view/5/14 |
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