Camptothecin-Loaded and Manganese Dioxide-Coated Polydopamine Nanomedicine Used for Magnetic Resonance Imaging Diagnosis and Chemo-Photothermal Therapy for Lung Cancer
Mingliang Su,* Yukun Chen,* Lijun Jia, Zhanxia Zhang Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lijun Jia; Zhanxia Zhang, E...
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| Language: | English |
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Dove Medical Press
2022-12-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/camptothecin-loaded-and-manganese-dioxide-coated-polydopamine-nanomedi-peer-reviewed-fulltext-article-IJN |
| _version_ | 1797974871190274048 |
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| author | Su M Chen Y Jia L Zhang Z |
| author_facet | Su M Chen Y Jia L Zhang Z |
| author_sort | Su M |
| collection | DOAJ |
| description | Mingliang Su,* Yukun Chen,* Lijun Jia, Zhanxia Zhang Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lijun Jia; Zhanxia Zhang, Email ljjia@shutcm.edu.cn; zhanxiazhang@shutcm.edu.cnIntroduction: Camptothecin (CPT) is a cytotoxic quinolone alkaloid (isolated from a traditional Chinese medicine Camptotheca acuminata), used for the treatment of various malignancies, which inhibits DNA topoisomerase I (Topo I). However, its drawbacks, such as poor water solubility, stability, and highly toxic side effects, limit its clinical application. Therefore, CPT needs to be prepared as a nanomedicine to improve solubility, reduce side effects, and synergize with other therapies to improve efficacy.Methods: In this work, we constructed CPT NPs (nanoparticles), which were CPT-loaded and manganese dioxide (MnO2)-coated polydopamine (PDA) nanomedicine. In vitro, we explored the antitumor effect including CPT NPs-induced cell proliferation inhibition, apoptosis and ferroptosis for tumor cell lines. In vivo, we established LLC tumor-bearing mice model to evaluate their tumor imaging and anticancer effects.Results: CPT NPs improve the water solubility and stability of CPT and reduce its toxic effects. It has good biocompatibility, excellent photothermal conversion ability for photothermal therapy (PTT) and pH release in the tumor microenvironment. It can inhibit tumor cell proliferation, induce apoptosis and result in ferroptosis of tumor cells. More significantly, this nanomedicine can provide information for the location and diagnosis of tumors via magnetic resonance imaging. In general, the nanomedicine integrated with diagnosis and treatment has excellent anticancer effect.Discussion: Altogether, this nanomedicine possesses the ability to diagnose and therapy through magnetic resonance imaging and chemo-photothermal therapy, respectively. In addition, the integrated diagnosis and treatment nanomedicine has potential clinical application prospects through treating lung cancer with high efficiency and low side effect. It can support the construction of related nano-delivery systems.Graphical Abstarct: Keywords: photothermal therapy, ferroptosis, NMR imaging, pH response, camptothecin |
| first_indexed | 2024-04-11T04:26:34Z |
| format | Article |
| id | doaj.art-e80819be26a84672a88e35fa35d09597 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-04-11T04:26:34Z |
| publishDate | 2022-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-e80819be26a84672a88e35fa35d095972022-12-29T17:48:02ZengDove Medical PressInternational Journal of Nanomedicine1178-20132022-12-01Volume 176687670580618Camptothecin-Loaded and Manganese Dioxide-Coated Polydopamine Nanomedicine Used for Magnetic Resonance Imaging Diagnosis and Chemo-Photothermal Therapy for Lung CancerSu MChen YJia LZhang ZMingliang Su,* Yukun Chen,* Lijun Jia, Zhanxia Zhang Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lijun Jia; Zhanxia Zhang, Email ljjia@shutcm.edu.cn; zhanxiazhang@shutcm.edu.cnIntroduction: Camptothecin (CPT) is a cytotoxic quinolone alkaloid (isolated from a traditional Chinese medicine Camptotheca acuminata), used for the treatment of various malignancies, which inhibits DNA topoisomerase I (Topo I). However, its drawbacks, such as poor water solubility, stability, and highly toxic side effects, limit its clinical application. Therefore, CPT needs to be prepared as a nanomedicine to improve solubility, reduce side effects, and synergize with other therapies to improve efficacy.Methods: In this work, we constructed CPT NPs (nanoparticles), which were CPT-loaded and manganese dioxide (MnO2)-coated polydopamine (PDA) nanomedicine. In vitro, we explored the antitumor effect including CPT NPs-induced cell proliferation inhibition, apoptosis and ferroptosis for tumor cell lines. In vivo, we established LLC tumor-bearing mice model to evaluate their tumor imaging and anticancer effects.Results: CPT NPs improve the water solubility and stability of CPT and reduce its toxic effects. It has good biocompatibility, excellent photothermal conversion ability for photothermal therapy (PTT) and pH release in the tumor microenvironment. It can inhibit tumor cell proliferation, induce apoptosis and result in ferroptosis of tumor cells. More significantly, this nanomedicine can provide information for the location and diagnosis of tumors via magnetic resonance imaging. In general, the nanomedicine integrated with diagnosis and treatment has excellent anticancer effect.Discussion: Altogether, this nanomedicine possesses the ability to diagnose and therapy through magnetic resonance imaging and chemo-photothermal therapy, respectively. In addition, the integrated diagnosis and treatment nanomedicine has potential clinical application prospects through treating lung cancer with high efficiency and low side effect. It can support the construction of related nano-delivery systems.Graphical Abstarct: Keywords: photothermal therapy, ferroptosis, NMR imaging, pH response, camptothecinhttps://www.dovepress.com/camptothecin-loaded-and-manganese-dioxide-coated-polydopamine-nanomedi-peer-reviewed-fulltext-article-IJNphotothermal therapyferroptosisnmr imagingph responsecamptothecin |
| spellingShingle | Su M Chen Y Jia L Zhang Z Camptothecin-Loaded and Manganese Dioxide-Coated Polydopamine Nanomedicine Used for Magnetic Resonance Imaging Diagnosis and Chemo-Photothermal Therapy for Lung Cancer International Journal of Nanomedicine photothermal therapy ferroptosis nmr imaging ph response camptothecin |
| title | Camptothecin-Loaded and Manganese Dioxide-Coated Polydopamine Nanomedicine Used for Magnetic Resonance Imaging Diagnosis and Chemo-Photothermal Therapy for Lung Cancer |
| title_full | Camptothecin-Loaded and Manganese Dioxide-Coated Polydopamine Nanomedicine Used for Magnetic Resonance Imaging Diagnosis and Chemo-Photothermal Therapy for Lung Cancer |
| title_fullStr | Camptothecin-Loaded and Manganese Dioxide-Coated Polydopamine Nanomedicine Used for Magnetic Resonance Imaging Diagnosis and Chemo-Photothermal Therapy for Lung Cancer |
| title_full_unstemmed | Camptothecin-Loaded and Manganese Dioxide-Coated Polydopamine Nanomedicine Used for Magnetic Resonance Imaging Diagnosis and Chemo-Photothermal Therapy for Lung Cancer |
| title_short | Camptothecin-Loaded and Manganese Dioxide-Coated Polydopamine Nanomedicine Used for Magnetic Resonance Imaging Diagnosis and Chemo-Photothermal Therapy for Lung Cancer |
| title_sort | camptothecin loaded and manganese dioxide coated polydopamine nanomedicine used for magnetic resonance imaging diagnosis and chemo photothermal therapy for lung cancer |
| topic | photothermal therapy ferroptosis nmr imaging ph response camptothecin |
| url | https://www.dovepress.com/camptothecin-loaded-and-manganese-dioxide-coated-polydopamine-nanomedi-peer-reviewed-fulltext-article-IJN |
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