The role of CXCR3 and its ligands in cancer
Chemokines are a class of small cytokines or signaling proteins that are secreted by cells. Owing to their ability to induce directional chemotaxis of nearby responding cells, they are called chemotactic cytokines. Chemokines and chemokine receptors have now been shown to influence many cellular fun...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1022688/full |
| _version_ | 1811189360341549056 |
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| author | Xiaoming Wang Yangyang Zhang Sen Wang Hongyan Ni Peng Zhao Guangyu Chen Benling Xu Long Yuan |
| author_facet | Xiaoming Wang Yangyang Zhang Sen Wang Hongyan Ni Peng Zhao Guangyu Chen Benling Xu Long Yuan |
| author_sort | Xiaoming Wang |
| collection | DOAJ |
| description | Chemokines are a class of small cytokines or signaling proteins that are secreted by cells. Owing to their ability to induce directional chemotaxis of nearby responding cells, they are called chemotactic cytokines. Chemokines and chemokine receptors have now been shown to influence many cellular functions, including survival, adhesion, invasion, and proliferation, and regulate chemokine levels. Most malignant tumors express one or more chemokine receptors. The CXC subgroup of chemokine receptors, CXCR3, is mainly expressed on the surface of activated T cells, B cells, and natural killer cells, and plays an essential role in infection, autoimmune diseases, and tumor immunity by binding to specific receptors on target cell membranes to induce targeted migration and immune responses. It is vital to treat infections, autoimmune diseases, and tumors. CXCR3 and its ligands, CXCL9, CXCL10, and CXCL11, are closely associated with the development and progression of many tumors. With the elucidation of its mechanism of action, CXCR3 is expected to become a new indicator for evaluating the prognosis of patients with tumors and a new target for clinical tumor immunotherapy. This article reviews the significance and mechanism of action of the chemokine receptor CXCR3 and its specific ligands in tumor development. |
| first_indexed | 2024-04-11T14:33:38Z |
| format | Article |
| id | doaj.art-e808c8f5a65d4a268397489c2bf113b3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T14:33:38Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e808c8f5a65d4a268397489c2bf113b32022-12-22T04:18:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10226881022688The role of CXCR3 and its ligands in cancerXiaoming Wang0Yangyang Zhang1Sen Wang2Hongyan Ni3Peng Zhao4Guangyu Chen5Benling Xu6Long Yuan7Department of Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Surgery, Henan No.3 Provincial People’s Hospital, Zhengzhou, ChinaDepartment of Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaChemokines are a class of small cytokines or signaling proteins that are secreted by cells. Owing to their ability to induce directional chemotaxis of nearby responding cells, they are called chemotactic cytokines. Chemokines and chemokine receptors have now been shown to influence many cellular functions, including survival, adhesion, invasion, and proliferation, and regulate chemokine levels. Most malignant tumors express one or more chemokine receptors. The CXC subgroup of chemokine receptors, CXCR3, is mainly expressed on the surface of activated T cells, B cells, and natural killer cells, and plays an essential role in infection, autoimmune diseases, and tumor immunity by binding to specific receptors on target cell membranes to induce targeted migration and immune responses. It is vital to treat infections, autoimmune diseases, and tumors. CXCR3 and its ligands, CXCL9, CXCL10, and CXCL11, are closely associated with the development and progression of many tumors. With the elucidation of its mechanism of action, CXCR3 is expected to become a new indicator for evaluating the prognosis of patients with tumors and a new target for clinical tumor immunotherapy. This article reviews the significance and mechanism of action of the chemokine receptor CXCR3 and its specific ligands in tumor development.https://www.frontiersin.org/articles/10.3389/fonc.2022.1022688/fullCXCR3CXCR3 and its ligandsCXCL9CXCL10CXCL11 |
| spellingShingle | Xiaoming Wang Yangyang Zhang Sen Wang Hongyan Ni Peng Zhao Guangyu Chen Benling Xu Long Yuan The role of CXCR3 and its ligands in cancer Frontiers in Oncology CXCR3 CXCR3 and its ligands CXCL9 CXCL10 CXCL11 |
| title | The role of CXCR3 and its ligands in cancer |
| title_full | The role of CXCR3 and its ligands in cancer |
| title_fullStr | The role of CXCR3 and its ligands in cancer |
| title_full_unstemmed | The role of CXCR3 and its ligands in cancer |
| title_short | The role of CXCR3 and its ligands in cancer |
| title_sort | role of cxcr3 and its ligands in cancer |
| topic | CXCR3 CXCR3 and its ligands CXCL9 CXCL10 CXCL11 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1022688/full |
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