Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples
Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. However, longitudinal evidence of sex-specific n...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323000993 |
| _version_ | 1797671431652245504 |
|---|---|
| author | Scott A. Jones Angelica M. Morales Gareth Harman Kalene A. Dominguez-Savage Sydney Gilbert Fiona C. Baker Massimiliano de Zambotti David B. Goldston Kate B. Nooner Duncan B. Clark Beatriz Luna Wesley K. Thompson Sandra A. Brown Susan F. Tapert Bonnie J. Nagel |
| author_facet | Scott A. Jones Angelica M. Morales Gareth Harman Kalene A. Dominguez-Savage Sydney Gilbert Fiona C. Baker Massimiliano de Zambotti David B. Goldston Kate B. Nooner Duncan B. Clark Beatriz Luna Wesley K. Thompson Sandra A. Brown Susan F. Tapert Bonnie J. Nagel |
| author_sort | Scott A. Jones |
| collection | DOAJ |
| description | Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. However, longitudinal evidence of sex-specific neuromaturation and associations with alcohol use remains limited. This project used generalized additive mixed models to examine sex-specific development of subcortical volumes and associations with recent alcohol use, using 7 longitudinal waves (n = 804, 51% female, ages 12–21 at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). A second, independent, longitudinal dataset, with up to four waves of data (n = 467, 43% female, ages 10–18 at baseline), was used to assess replicability. Significant, replicable non-linear normative volumetric changes with age were evident in the caudate, putamen, thalamus, pallidum, amygdala and hippocampus. Significant, replicable negative associations between subcortical volume and alcohol use were found in the hippocampus in all youth, and the caudate and thalamus in female but not male youth, with significant interactions present in the caudate, thalamus and putamen. Findings suggest a structural vulnerability to alcohol use, or a predisposition to drink alcohol based on brain structure, with female youth potentially showing heightened risk, compared to male youth. |
| first_indexed | 2024-03-11T21:15:26Z |
| format | Article |
| id | doaj.art-e809ef1f259d4cb68093bc8c9f1a75ba |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-11T21:15:26Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-e809ef1f259d4cb68093bc8c9f1a75ba2023-09-29T04:44:00ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-10-0163101294Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samplesScott A. Jones0Angelica M. Morales1Gareth Harman2Kalene A. Dominguez-Savage3Sydney Gilbert4Fiona C. Baker5Massimiliano de Zambotti6David B. Goldston7Kate B. Nooner8Duncan B. Clark9Beatriz Luna10Wesley K. Thompson11Sandra A. Brown12Susan F. Tapert13Bonnie J. Nagel14Department of Psychiatry, Oregon Health & Science University, Portland, OR, USADepartment of Psychiatry, Oregon Health & Science University, Portland, OR, USADepartment of Psychiatry, Oregon Health & Science University, Portland, OR, USA; Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, USADepartment of Psychiatry, Oregon Health & Science University, Portland, OR, USADepartment of Psychiatry, Oregon Health & Science University, Portland, OR, USACenter for Health Sciences, SRI International, Menlo Park, CA, USACenter for Health Sciences, SRI International, Menlo Park, CA, USADepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USADepartment of Psychology, University of North Carolina Wilmington, Wilmington, NC, USADepartments of Psychiatry, Psychology and Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USADepartments of Psychiatry, Psychology and Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USAPopulation Neuroscience and Genetics Lab, University of California, San Diego, CA, USADepartment of Psychology and Psychiatry, University of California, San Diego, La Jolla, CA, USADepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USADepartment of Psychiatry, Oregon Health & Science University, Portland, OR, USA; Correspondence to: Oregon Health & Science University, 3181 SW Sam Jackson Park Road UHN-80R1, Portland, OR 97239, USA.Subcortical brain morphometry matures across adolescence and young adulthood, a time when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies have shown alcohol use is associated with altered subcortical morphometry. However, longitudinal evidence of sex-specific neuromaturation and associations with alcohol use remains limited. This project used generalized additive mixed models to examine sex-specific development of subcortical volumes and associations with recent alcohol use, using 7 longitudinal waves (n = 804, 51% female, ages 12–21 at baseline) from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). A second, independent, longitudinal dataset, with up to four waves of data (n = 467, 43% female, ages 10–18 at baseline), was used to assess replicability. Significant, replicable non-linear normative volumetric changes with age were evident in the caudate, putamen, thalamus, pallidum, amygdala and hippocampus. Significant, replicable negative associations between subcortical volume and alcohol use were found in the hippocampus in all youth, and the caudate and thalamus in female but not male youth, with significant interactions present in the caudate, thalamus and putamen. Findings suggest a structural vulnerability to alcohol use, or a predisposition to drink alcohol based on brain structure, with female youth potentially showing heightened risk, compared to male youth.http://www.sciencedirect.com/science/article/pii/S1878929323000993MRISex differencesAdolescenceAlcoholLongitudinalReplication |
| spellingShingle | Scott A. Jones Angelica M. Morales Gareth Harman Kalene A. Dominguez-Savage Sydney Gilbert Fiona C. Baker Massimiliano de Zambotti David B. Goldston Kate B. Nooner Duncan B. Clark Beatriz Luna Wesley K. Thompson Sandra A. Brown Susan F. Tapert Bonnie J. Nagel Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples Developmental Cognitive Neuroscience MRI Sex differences Adolescence Alcohol Longitudinal Replication |
| title | Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples |
| title_full | Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples |
| title_fullStr | Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples |
| title_full_unstemmed | Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples |
| title_short | Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples |
| title_sort | associations between alcohol use and sex specific maturation of subcortical gray matter morphometry from adolescence to adulthood replication across two longitudinal samples |
| topic | MRI Sex differences Adolescence Alcohol Longitudinal Replication |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323000993 |
| work_keys_str_mv | AT scottajones associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT angelicammorales associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT garethharman associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT kaleneadominguezsavage associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT sydneygilbert associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT fionacbaker associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT massimilianodezambotti associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT davidbgoldston associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT katebnooner associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT duncanbclark associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT beatrizluna associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT wesleykthompson associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT sandraabrown associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT susanftapert associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples AT bonniejnagel associationsbetweenalcoholuseandsexspecificmaturationofsubcorticalgraymattermorphometryfromadolescencetoadulthoodreplicationacrosstwolongitudinalsamples |