Lentigo maligna mimicking invasive melanoma in Mohs surgery: a case report [v1; ref status: indexed, http://f1000r.es/2mp]
Lentigo maligna is a lentiginous proliferation of atypical melanocytes confined to the epidermis, typically on chronically sun-damaged skin. Following biopsy and exclusion of invasive disease, therapy may involve Mohs surgery, topical treatment or radiotherapy. However, lentigo maligna often involve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2014-01-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | http://f1000research.com/articles/3-25/v1 |
| _version_ | 1819104062121967616 |
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| author | Teresa Tsakok Nisith Sheth Alistair Robson Catherine Gleeson Raj Mallipeddi |
| author_facet | Teresa Tsakok Nisith Sheth Alistair Robson Catherine Gleeson Raj Mallipeddi |
| author_sort | Teresa Tsakok |
| collection | DOAJ |
| description | Lentigo maligna is a lentiginous proliferation of atypical melanocytes confined to the epidermis, typically on chronically sun-damaged skin. Following biopsy and exclusion of invasive disease, therapy may involve Mohs surgery, topical treatment or radiotherapy. However, lentigo maligna often involves adnexal structures, creating histological difficulty in distinguishing these foci from invasive melanoma. We present a case in which, during Mohs excision, a nodule of severely atypical melanocytes appeared to lie within the dermis, potentially altering treatment and prognosis. The use of laminin-5 provided a means of resolving this diagnostic dilemma, facilitating continuation of Mohs surgery until tumour clearance was achieved. |
| first_indexed | 2024-12-22T02:00:22Z |
| format | Article |
| id | doaj.art-e809f6bcdf4643dab86db2c7e24f4051 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-22T02:00:22Z |
| publishDate | 2014-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-e809f6bcdf4643dab86db2c7e24f40512022-12-21T18:42:40ZengF1000 Research LtdF1000Research2046-14022014-01-01310.12688/f1000research.3-25.v13409Lentigo maligna mimicking invasive melanoma in Mohs surgery: a case report [v1; ref status: indexed, http://f1000r.es/2mp]Teresa Tsakok0Nisith Sheth1Alistair Robson2Catherine Gleeson3Raj Mallipeddi4Dermatological Surgery and Laser Unit, St John’s Institute of Dermatology, St Thomas’ Hospital, London, UKDermatological Surgery and Laser Unit, St John’s Institute of Dermatology, St Thomas’ Hospital, London, UKDermatological Surgery and Laser Unit, St John’s Institute of Dermatology, St Thomas’ Hospital, London, UKDermatological Surgery and Laser Unit, St John’s Institute of Dermatology, St Thomas’ Hospital, London, UKDermatological Surgery and Laser Unit, St John’s Institute of Dermatology, St Thomas’ Hospital, London, UKLentigo maligna is a lentiginous proliferation of atypical melanocytes confined to the epidermis, typically on chronically sun-damaged skin. Following biopsy and exclusion of invasive disease, therapy may involve Mohs surgery, topical treatment or radiotherapy. However, lentigo maligna often involves adnexal structures, creating histological difficulty in distinguishing these foci from invasive melanoma. We present a case in which, during Mohs excision, a nodule of severely atypical melanocytes appeared to lie within the dermis, potentially altering treatment and prognosis. The use of laminin-5 provided a means of resolving this diagnostic dilemma, facilitating continuation of Mohs surgery until tumour clearance was achieved.http://f1000research.com/articles/3-25/v1Skin Cancers (incl. Melanoma & Lymphoma) |
| spellingShingle | Teresa Tsakok Nisith Sheth Alistair Robson Catherine Gleeson Raj Mallipeddi Lentigo maligna mimicking invasive melanoma in Mohs surgery: a case report [v1; ref status: indexed, http://f1000r.es/2mp] F1000Research Skin Cancers (incl. Melanoma & Lymphoma) |
| title | Lentigo maligna mimicking invasive melanoma in Mohs surgery: a case report [v1; ref status: indexed, http://f1000r.es/2mp] |
| title_full | Lentigo maligna mimicking invasive melanoma in Mohs surgery: a case report [v1; ref status: indexed, http://f1000r.es/2mp] |
| title_fullStr | Lentigo maligna mimicking invasive melanoma in Mohs surgery: a case report [v1; ref status: indexed, http://f1000r.es/2mp] |
| title_full_unstemmed | Lentigo maligna mimicking invasive melanoma in Mohs surgery: a case report [v1; ref status: indexed, http://f1000r.es/2mp] |
| title_short | Lentigo maligna mimicking invasive melanoma in Mohs surgery: a case report [v1; ref status: indexed, http://f1000r.es/2mp] |
| title_sort | lentigo maligna mimicking invasive melanoma in mohs surgery a case report v1 ref status indexed http f1000r es 2mp |
| topic | Skin Cancers (incl. Melanoma & Lymphoma) |
| url | http://f1000research.com/articles/3-25/v1 |
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