Construction and Immunological Evaluation of an Adenoviral Vector-Based Vaccine Candidate for Lassa Fever

Construction and Immunological Evaluation of an Adenoviral Vector-Based Vaccine Candidate for Lassa Fever

Lassa virus (LASV) is a rodent-borne arenavirus circulating in West African regions that causes Lassa fever (LF). LF is normally asymptomatic at the initial infection stage, but can progress to severe disease with multiorgan collapse and hemorrhagic fever. To date, the therapeutic choices are limite...

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Bibliographic Details
Main Authors: Meirong Wang, Ruihua Li, Yaohui Li, Changming Yu, Xiangyang Chi, Shipo Wu, Shulin Liu, Junjie Xu, Wei Chen
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Viruses
Subjects:
Lassa virus
Lassa fever
vaccine
adenovirus
glycoprotein
Online Access:https://www.mdpi.com/1999-4915/13/3/484

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