MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR
The retrospective analysis of the influence of histological changes in donor kidneys on the KAG function during first year was conducted in 75 recipients of a cadaveric kidney. The state of tubuli, glomeruli, interstitium, vessels was assessed semiquantitatively in the material of «0»-biopsies. The...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2010-06-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/285 |
| _version_ | 1797872107009343488 |
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| author | A. V. Trailin T. N. Nikonenko A. S. Nikonenko T. I. Ostapenko N. N. Polyakov P. V. Pavlov O. D. Pokrova |
| author_facet | A. V. Trailin T. N. Nikonenko A. S. Nikonenko T. I. Ostapenko N. N. Polyakov P. V. Pavlov O. D. Pokrova |
| author_sort | A. V. Trailin |
| collection | DOAJ |
| description | The retrospective analysis of the influence of histological changes in donor kidneys on the KAG function during first year was conducted in 75 recipients of a cadaveric kidney. The state of tubuli, glomeruli, interstitium, vessels was assessed semiquantitatively in the material of «0»-biopsies. The endpoints were serum creatinine and glomerular filtration rate at 3, 6 and 12 months. KAG function in the first year is programmed by histological changes in all compartments of donor kidney. Influence of histological changes is time-dependent: the effect of ischemic damage shows up quickly, but disappeared after 6 months; the effect of arteriolohyalinosis and arteriosclerosis begins to show up later – since 6 months; changes in glomeruli have influence on a KAG function in 3 months and 1 year; interstitial fibrosis in cortex and medulla negatively influences KAG function on the extent of all first year. Our data argue for the necessity of «0»-biopsies examination for the prediction of KAG subsequent function. |
| first_indexed | 2024-04-10T00:54:39Z |
| format | Article |
| id | doaj.art-e80bcfa68a0b4737a90d71b3967ec7da |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:54:39Z |
| publishDate | 2010-06-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-e80bcfa68a0b4737a90d71b3967ec7da2023-03-13T10:37:20ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912010-06-01121212610.15825/1995-1191-2010-1-21-26228MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEARA. V. Trailin0T. N. Nikonenko1A. S. Nikonenko2T. I. Ostapenko3N. N. Polyakov4P. V. Pavlov5O. D. Pokrova6Zaporizhzhya interregional transplantation centreZaporizhzhya interregional transplantation centreZaporizhzhya interregional transplantation centre Zaporizhzhya medical academy of postgraduate educationZaporizhzhya medical academy of postgraduate educationZaporizhzhya interregional transplantation centre Zaporizhzhya medical academy of postgraduate educationDnypropetrovsk Mechnikov regional clinical hospitalDnypropetrovsk Mechnikov regional clinical hospitalThe retrospective analysis of the influence of histological changes in donor kidneys on the KAG function during first year was conducted in 75 recipients of a cadaveric kidney. The state of tubuli, glomeruli, interstitium, vessels was assessed semiquantitatively in the material of «0»-biopsies. The endpoints were serum creatinine and glomerular filtration rate at 3, 6 and 12 months. KAG function in the first year is programmed by histological changes in all compartments of donor kidney. Influence of histological changes is time-dependent: the effect of ischemic damage shows up quickly, but disappeared after 6 months; the effect of arteriolohyalinosis and arteriosclerosis begins to show up later – since 6 months; changes in glomeruli have influence on a KAG function in 3 months and 1 year; interstitial fibrosis in cortex and medulla negatively influences KAG function on the extent of all first year. Our data argue for the necessity of «0»-biopsies examination for the prediction of KAG subsequent function.https://journal.transpl.ru/vtio/article/view/285kidney transplantation«0»-biopsiesmorphological diagnosticsallograft function and survival |
| spellingShingle | A. V. Trailin T. N. Nikonenko A. S. Nikonenko T. I. Ostapenko N. N. Polyakov P. V. Pavlov O. D. Pokrova MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR Vestnik Transplantologii i Iskusstvennyh Organov kidney transplantation «0»-biopsies morphological diagnostics allograft function and survival |
| title | MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR |
| title_full | MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR |
| title_fullStr | MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR |
| title_full_unstemmed | MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR |
| title_short | MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR |
| title_sort | morphological predictors of kidney allograft kag function during first posttransplant year |
| topic | kidney transplantation «0»-biopsies morphological diagnostics allograft function and survival |
| url | https://journal.transpl.ru/vtio/article/view/285 |
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