Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (<i>Oryza sativa</i> L. cv. Pieisu 1 CMU) for Cosmetic Application
<i>Oryza sativa</i> L. cv. Pieisu 1 CMU (PES1CMU) has a high anthocyanin content in the colored bran and high phenolic content in the husk. Biologically active compounds in plants are available as dietary supplements and cosmetics. To expand the utilization of natural resources, PES1CMU...
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MDPI AG
2023-02-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/4/970 |
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| author | Pichchapa Linsaenkart Warintorn Ruksiriwanich Pensak Jantrawut Chuda Chittasupho Pornchai Rachtanapun Kittisak Jantanasakulwong Sarana Rose Sommano Chanakan Prom-u-thai Sansanee Jamjod Chaiwat Arjin Korawan Sringarm Francisco J. Barba |
| author_facet | Pichchapa Linsaenkart Warintorn Ruksiriwanich Pensak Jantrawut Chuda Chittasupho Pornchai Rachtanapun Kittisak Jantanasakulwong Sarana Rose Sommano Chanakan Prom-u-thai Sansanee Jamjod Chaiwat Arjin Korawan Sringarm Francisco J. Barba |
| author_sort | Pichchapa Linsaenkart |
| collection | DOAJ |
| description | <i>Oryza sativa</i> L. cv. Pieisu 1 CMU (PES1CMU) has a high anthocyanin content in the colored bran and high phenolic content in the husk. Biologically active compounds in plants are available as dietary supplements and cosmetics. To expand the utilization of natural resources, PES1CMU will be a natural remedy for skin hyperpigmentation and aging. Cell-free tyrosinase inhibition and scavenging assays were used to screen all extracts, including PES1CMU-rice bran oil (RBO), PES1CMU-defatted rice bran (DFRB), and PES1CMU-husk (H). PES1CMU extracts were first examined in IBMX-stimulated B16 cells and H<sub>2</sub>O<sub>2</sub>-induced fibroblasts. The results exhibited that PES1CMU-DFRB was the most effective inhibitor of mushroom tyrosinase, intracellular melanin production (fold change of 1.11 ± 0.01), and tyrosinase activity (fold change of 1.22 ± 0.10) in IBMX-stimulated B16 cells. Particularly, PES1CMU-DFRB showed a comparable whitening effect to the standard arbutin with no significant difference (<i>p</i> > 0.05). Moreover, PES1CMU-DFRB and PES1CMU-H demonstrated strong scavenging activities. After accelerated cell aging caused by H<sub>2</sub>O<sub>2</sub> exposure in fibroblasts, the levels of malondialdehyde production in all PES1CMU-treated fibroblasts were comparable with those of standard <span style="font-variant: small-caps;">l</span><span style="font-variant: small-caps;">-</span>ascorbic acid (<i>p</i> > 0.05). Besides, PES1CMU-DFRB and PES1CMU-H treatment significantly inhibited collagen degradation against MMP-2 compared to <span style="font-variant: small-caps;">l</span><span style="font-variant: small-caps;">-</span>ascorbic acid-treated cells (<i>p</i> > 0.05). PES1CMU rice-processing wastes (DFRB and H) could become potential natural sources for dermatocosmetic constituents in skin anti-aging and whitening products. |
| first_indexed | 2024-03-11T08:15:20Z |
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| last_indexed | 2024-03-11T08:15:20Z |
| publishDate | 2023-02-01 |
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| spelling | doaj.art-e810efe73acc47da8aad419b636af1f02023-11-16T22:49:53ZengMDPI AGPlants2223-77472023-02-0112497010.3390/plants12040970Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (<i>Oryza sativa</i> L. cv. Pieisu 1 CMU) for Cosmetic ApplicationPichchapa Linsaenkart0Warintorn Ruksiriwanich1Pensak Jantrawut2Chuda Chittasupho3Pornchai Rachtanapun4Kittisak Jantanasakulwong5Sarana Rose Sommano6Chanakan Prom-u-thai7Sansanee Jamjod8Chaiwat Arjin9Korawan Sringarm10Francisco J. Barba11Doctor of Philosophy Program in Pharmacy, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandCluster of Agro Bio-Circular-Green Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, ThailandCluster of Agro Bio-Circular-Green Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, ThailandCluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 50200, ThailandLanna Rice Research Center, Chiang Mai University, Chiang Mai 50200, ThailandLanna Rice Research Center, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, ThailandCluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de València, 46100 València, Spain<i>Oryza sativa</i> L. cv. Pieisu 1 CMU (PES1CMU) has a high anthocyanin content in the colored bran and high phenolic content in the husk. Biologically active compounds in plants are available as dietary supplements and cosmetics. To expand the utilization of natural resources, PES1CMU will be a natural remedy for skin hyperpigmentation and aging. Cell-free tyrosinase inhibition and scavenging assays were used to screen all extracts, including PES1CMU-rice bran oil (RBO), PES1CMU-defatted rice bran (DFRB), and PES1CMU-husk (H). PES1CMU extracts were first examined in IBMX-stimulated B16 cells and H<sub>2</sub>O<sub>2</sub>-induced fibroblasts. The results exhibited that PES1CMU-DFRB was the most effective inhibitor of mushroom tyrosinase, intracellular melanin production (fold change of 1.11 ± 0.01), and tyrosinase activity (fold change of 1.22 ± 0.10) in IBMX-stimulated B16 cells. Particularly, PES1CMU-DFRB showed a comparable whitening effect to the standard arbutin with no significant difference (<i>p</i> > 0.05). Moreover, PES1CMU-DFRB and PES1CMU-H demonstrated strong scavenging activities. After accelerated cell aging caused by H<sub>2</sub>O<sub>2</sub> exposure in fibroblasts, the levels of malondialdehyde production in all PES1CMU-treated fibroblasts were comparable with those of standard <span style="font-variant: small-caps;">l</span><span style="font-variant: small-caps;">-</span>ascorbic acid (<i>p</i> > 0.05). Besides, PES1CMU-DFRB and PES1CMU-H treatment significantly inhibited collagen degradation against MMP-2 compared to <span style="font-variant: small-caps;">l</span><span style="font-variant: small-caps;">-</span>ascorbic acid-treated cells (<i>p</i> > 0.05). PES1CMU rice-processing wastes (DFRB and H) could become potential natural sources for dermatocosmetic constituents in skin anti-aging and whitening products.https://www.mdpi.com/2223-7747/12/4/970anthocyaninantioxidantcollagen stimulatormatrix metalloproteinase 2 inhibitionmelanogenesis inhibitor<i>Oryza sativa</i> |
| spellingShingle | Pichchapa Linsaenkart Warintorn Ruksiriwanich Pensak Jantrawut Chuda Chittasupho Pornchai Rachtanapun Kittisak Jantanasakulwong Sarana Rose Sommano Chanakan Prom-u-thai Sansanee Jamjod Chaiwat Arjin Korawan Sringarm Francisco J. Barba Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (<i>Oryza sativa</i> L. cv. Pieisu 1 CMU) for Cosmetic Application Plants anthocyanin antioxidant collagen stimulator matrix metalloproteinase 2 inhibition melanogenesis inhibitor <i>Oryza sativa</i> |
| title | Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (<i>Oryza sativa</i> L. cv. Pieisu 1 CMU) for Cosmetic Application |
| title_full | Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (<i>Oryza sativa</i> L. cv. Pieisu 1 CMU) for Cosmetic Application |
| title_fullStr | Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (<i>Oryza sativa</i> L. cv. Pieisu 1 CMU) for Cosmetic Application |
| title_full_unstemmed | Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (<i>Oryza sativa</i> L. cv. Pieisu 1 CMU) for Cosmetic Application |
| title_short | Natural Melanogenesis Inhibitor, Antioxidant, and Collagen Biosynthesis Stimulator of Phytochemicals in Rice Bran and Husk Extracts from Purple Glutinous Rice (<i>Oryza sativa</i> L. cv. Pieisu 1 CMU) for Cosmetic Application |
| title_sort | natural melanogenesis inhibitor antioxidant and collagen biosynthesis stimulator of phytochemicals in rice bran and husk extracts from purple glutinous rice i oryza sativa i l cv pieisu 1 cmu for cosmetic application |
| topic | anthocyanin antioxidant collagen stimulator matrix metalloproteinase 2 inhibition melanogenesis inhibitor <i>Oryza sativa</i> |
| url | https://www.mdpi.com/2223-7747/12/4/970 |
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