Molecular toxicity study on glyphosate, Roundup MON 52276 and a low-dose pesticide mixture administered to adult Female rats for 90 days

We describe a comprehensive repository describing a collection of data from a range of studies investigating the molecular mechanisms of toxicity of glyphosate, the glyphosate-based herbicide commercial formulation Roundup, and a mixture of glyphosate and 5 other most frequently used pesticides (azo...

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Main Authors: Robin Mesnage, Michael N. Antoniou
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:All Life
Subjects:
Online Access:http://dx.doi.org/10.1080/26895293.2022.2156626
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author Robin Mesnage
Michael N. Antoniou
author_facet Robin Mesnage
Michael N. Antoniou
author_sort Robin Mesnage
collection DOAJ
description We describe a comprehensive repository describing a collection of data from a range of studies investigating the molecular mechanisms of toxicity of glyphosate, the glyphosate-based herbicide commercial formulation Roundup, and a mixture of glyphosate and 5 other most frequently used pesticides (azoxystrobin, boscalid, chlorpyrifos, imidacloprid and thiabendazole) present as residues in food products in Europe. The data were obtained by analysing tissues from rats exposed to the pesticides for 90 days via drinking water. The administration of the mixture of six pesticides was chosen to mimic a possible human exposure scenario. We compared conventional methods used in regulatory toxicity studies to evaluate the safety of pesticide exposure (gross pathology, serum biochemistry) to new molecular profiling methods encompassing the analysis of the caecum and blood metabolome, liver transcriptome, liver DNA methylation, liver small RNA profiles, and caecum metagenome of the exposed animals. Altogether, these investigations provided in-depth molecular profiling in laboratory animals exposed to pesticides revealing metabolic perturbations that would remain undetected by standard regulatory biochemical measures. Our results highlight how multi-omics phenotyping can be used to improve the predictability of health risk assessment from exposure to toxic chemicals to better protect public health.
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spelling doaj.art-e8127bf17e594f9786759323d47f6d692024-03-28T09:48:51ZengTaylor & Francis GroupAll Life2689-53072022-12-011511273127510.1080/26895293.2022.21566262156626Molecular toxicity study on glyphosate, Roundup MON 52276 and a low-dose pesticide mixture administered to adult Female rats for 90 daysRobin Mesnage0Michael N. Antoniou1Guy’s HospitalGuy’s HospitalWe describe a comprehensive repository describing a collection of data from a range of studies investigating the molecular mechanisms of toxicity of glyphosate, the glyphosate-based herbicide commercial formulation Roundup, and a mixture of glyphosate and 5 other most frequently used pesticides (azoxystrobin, boscalid, chlorpyrifos, imidacloprid and thiabendazole) present as residues in food products in Europe. The data were obtained by analysing tissues from rats exposed to the pesticides for 90 days via drinking water. The administration of the mixture of six pesticides was chosen to mimic a possible human exposure scenario. We compared conventional methods used in regulatory toxicity studies to evaluate the safety of pesticide exposure (gross pathology, serum biochemistry) to new molecular profiling methods encompassing the analysis of the caecum and blood metabolome, liver transcriptome, liver DNA methylation, liver small RNA profiles, and caecum metagenome of the exposed animals. Altogether, these investigations provided in-depth molecular profiling in laboratory animals exposed to pesticides revealing metabolic perturbations that would remain undetected by standard regulatory biochemical measures. Our results highlight how multi-omics phenotyping can be used to improve the predictability of health risk assessment from exposure to toxic chemicals to better protect public health.http://dx.doi.org/10.1080/26895293.2022.2156626pesticidesgut microbiomemetabolomeliver functionglyphosate
spellingShingle Robin Mesnage
Michael N. Antoniou
Molecular toxicity study on glyphosate, Roundup MON 52276 and a low-dose pesticide mixture administered to adult Female rats for 90 days
All Life
pesticides
gut microbiome
metabolome
liver function
glyphosate
title Molecular toxicity study on glyphosate, Roundup MON 52276 and a low-dose pesticide mixture administered to adult Female rats for 90 days
title_full Molecular toxicity study on glyphosate, Roundup MON 52276 and a low-dose pesticide mixture administered to adult Female rats for 90 days
title_fullStr Molecular toxicity study on glyphosate, Roundup MON 52276 and a low-dose pesticide mixture administered to adult Female rats for 90 days
title_full_unstemmed Molecular toxicity study on glyphosate, Roundup MON 52276 and a low-dose pesticide mixture administered to adult Female rats for 90 days
title_short Molecular toxicity study on glyphosate, Roundup MON 52276 and a low-dose pesticide mixture administered to adult Female rats for 90 days
title_sort molecular toxicity study on glyphosate roundup mon 52276 and a low dose pesticide mixture administered to adult female rats for 90 days
topic pesticides
gut microbiome
metabolome
liver function
glyphosate
url http://dx.doi.org/10.1080/26895293.2022.2156626
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