Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy
Abstract Precision medicine that takes individual variability into account is a new way to minimize the individual variability for precise diagnosis and to establish the certain strategies of efficient therapy. Due to miniaturization sensing area, remoting detection, and flexible operation of light,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-10-01
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| Series: | Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/INMD.20230022 |
| _version_ | 1797644518768508928 |
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| author | Zewei Luo Mingyue Li Xinyu Kong Yu Li Wenwen Li Ze Tian Qun Cao Muhammad Haider Zaman Yongxin Li Wei Xiao Yixiang Duan |
| author_facet | Zewei Luo Mingyue Li Xinyu Kong Yu Li Wenwen Li Ze Tian Qun Cao Muhammad Haider Zaman Yongxin Li Wei Xiao Yixiang Duan |
| author_sort | Zewei Luo |
| collection | DOAJ |
| description | Abstract Precision medicine that takes individual variability into account is a new way to minimize the individual variability for precise diagnosis and to establish the certain strategies of efficient therapy. Due to miniaturization sensing area, remoting detection, and flexible operation of light, fiber optics have been successfully used to develop in vitro, wearable, and implanted biosensors, exhibiting high potential in precision medicine from the diagnosis in vitro to therapy in vivo. When modified with the recognition element, the fiber optic‐based biosensor enables the point of care testing for the detection of disease biomarkers. Meanwhile, the fiber optics packaged in a needle/catheter also monitor the medical Internet of things for the continuous assessment of human health. Moreover, the light from the cladding or leaky mode in the fiber optics excites the strong photothermal effect for therapy. The fiber optic‐based biosensor addressed the drawbacks of plasmonic photothermal therapy that limited penetration depths and non‐selectivity therapy. When integrated with a photothermal agent, the fiber optic‐based biosensors provide in situ information for the diagnosis as well as specifically and efficiently kill the tumor cells in deep tissues. In this review, we summarized the advances of fiber optic‐based biosensors in the diagnosis in vitro and therapy in vivo. The challenges and prospection of the fiber optic‐based biosensor application in precision medicine were also explored in depth. |
| first_indexed | 2024-03-11T14:31:41Z |
| format | Article |
| id | doaj.art-e81422153d1746babaf0bd039cd29939 |
| institution | Directory Open Access Journal |
| issn | 2832-6245 |
| language | English |
| last_indexed | 2024-03-11T14:31:41Z |
| publishDate | 2023-10-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj.art-e81422153d1746babaf0bd039cd299392023-10-31T08:13:22ZengWiley-VCHInterdisciplinary Medicine2832-62452023-10-0114n/an/a10.1002/INMD.20230022Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapyZewei Luo0Mingyue Li1Xinyu Kong2Yu Li3Wenwen Li4Ze Tian5Qun Cao6Muhammad Haider Zaman7Yongxin Li8Wei Xiao9Yixiang Duan10Research Center of Analytical Instrumentation School of Mechanical Engineering Sichuan University Chengdu ChinaResearch Center of Analytical Instrumentation School of Mechanical Engineering Sichuan University Chengdu ChinaKey Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry & Materials Science Northwest University Xi'an Shaanxi ChinaResearch Center of Analytical Instrumentation Key Laboratory of Bio‐resource and Eco‐environment Ministry of Education College of Life Science Sichuan University Chengdu Sichuan ChinaWest China School of Public Health and West China Fourth Hospital Sichuan University Chengdu ChinaResearch Center of Analytical Instrumentation School of Mechanical Engineering Sichuan University Chengdu ChinaKoch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge Massachusetts USAResearch Center of Analytical Instrumentation School of Mechanical Engineering Sichuan University Chengdu ChinaWest China School of Public Health and West China Fourth Hospital Sichuan University Chengdu ChinaThe Affiliated Guangdong Second Provincial General Hospital of Jinan University Guangzhou ChinaResearch Center of Analytical Instrumentation School of Mechanical Engineering Sichuan University Chengdu ChinaAbstract Precision medicine that takes individual variability into account is a new way to minimize the individual variability for precise diagnosis and to establish the certain strategies of efficient therapy. Due to miniaturization sensing area, remoting detection, and flexible operation of light, fiber optics have been successfully used to develop in vitro, wearable, and implanted biosensors, exhibiting high potential in precision medicine from the diagnosis in vitro to therapy in vivo. When modified with the recognition element, the fiber optic‐based biosensor enables the point of care testing for the detection of disease biomarkers. Meanwhile, the fiber optics packaged in a needle/catheter also monitor the medical Internet of things for the continuous assessment of human health. Moreover, the light from the cladding or leaky mode in the fiber optics excites the strong photothermal effect for therapy. The fiber optic‐based biosensor addressed the drawbacks of plasmonic photothermal therapy that limited penetration depths and non‐selectivity therapy. When integrated with a photothermal agent, the fiber optic‐based biosensors provide in situ information for the diagnosis as well as specifically and efficiently kill the tumor cells in deep tissues. In this review, we summarized the advances of fiber optic‐based biosensors in the diagnosis in vitro and therapy in vivo. The challenges and prospection of the fiber optic‐based biosensor application in precision medicine were also explored in depth.https://doi.org/10.1002/INMD.20230022biosensordiagnosisfiber opticprecision medicinetherapy |
| spellingShingle | Zewei Luo Mingyue Li Xinyu Kong Yu Li Wenwen Li Ze Tian Qun Cao Muhammad Haider Zaman Yongxin Li Wei Xiao Yixiang Duan Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy Interdisciplinary Medicine biosensor diagnosis fiber optic precision medicine therapy |
| title | Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy |
| title_full | Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy |
| title_fullStr | Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy |
| title_full_unstemmed | Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy |
| title_short | Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy |
| title_sort | advance on fiber optic based biosensors for precision medicine from diagnosis to therapy |
| topic | biosensor diagnosis fiber optic precision medicine therapy |
| url | https://doi.org/10.1002/INMD.20230022 |
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