Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex

Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex

Lactate oxidation with NAD+ as electron acceptor is a highly endergonic reaction. Some anaerobic bacteria overcome the energetic hurdle by flavin-based electron bifurcation/confurcation (FBEB/FBEC) using a lactate dehydrogenase (Ldh) in concert with the electron-transferring proteins EtfA and EtfB....

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Bibliographic Details
Main Authors: Kanwal Kayastha, Alexander Katsyv, Christina Himmrich, Sonja Welsch, Jan M Schuller, Ulrich Ermler, Volker Müller
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
electron bifurcation
bioenergetics
flavin
lactate dehydrogenase
electron-transferring flavoprotein
cryo-EM structure
Online Access:https://elifesciences.org/articles/77095

Internet

https://elifesciences.org/articles/77095

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