Morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium level
Introduction: There is not enough data on the effects of primary hyperparathyroidism (pHPT) on morning blood pressure surge (MBPS) in the literature. We aimed to determine whether there was any change in MBPS value in patients with hypertensive pHPT and to determine the parameters related to MBPS. M...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-01-01
|
| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2019.1590388 |
| _version_ | 1797681338834223104 |
|---|---|
| author | Derya Demirtas Hilmi Erdem Sumbul Abdullah Orhan Demirtas Yahya Kemal Icen Erdinc Gulumsek Hasan Koca Örsan Deniz Urgun Mevlut Koc |
| author_facet | Derya Demirtas Hilmi Erdem Sumbul Abdullah Orhan Demirtas Yahya Kemal Icen Erdinc Gulumsek Hasan Koca Örsan Deniz Urgun Mevlut Koc |
| author_sort | Derya Demirtas |
| collection | DOAJ |
| description | Introduction: There is not enough data on the effects of primary hyperparathyroidism (pHPT) on morning blood pressure surge (MBPS) in the literature. We aimed to determine whether there was any change in MBPS value in patients with hypertensive pHPT and to determine the parameters related to MBPS. Method: 80 patients with newly diagnosed pHPT with hypertension (HT) and 80 controls with newly diagnosed hypertension were included. Routine laboratory examinations and ambulatory blood pressure monitoring (ABPM) were performed in all patients. Results: In patients with pHPT, blood urea nitrogen (BUN), triglyceride, hs-CRP, uric acid, serum calcium (Ca), parathormone (PTH), daytime SBP and MBPS levels are higher than others (p < 0.05). Body mass index (BMI) and Ca level were independently associated with MBPS. In patients with MBPS ≥ 25 mmHg, BMI, BUN, creatinine, uric acid, Ca and PTH levels were found to be higher than others. BMI values and Ca levels determine the patients with MBPS ≥ 25 mmHg (p < 0.05) independently. According to this analysis, increase in BMI (for each 1 unit) and Ca level (for each 0.1 mg/dL) was found to increase the probability of MBPS ≥ 25 mmHg by 17.8% and 7.7%, respectively. When the cut-off value for Ca was taken as 10 mg/dL, the patients with MBPS ≥ 25 mmHg were determined with 73.5% sensitivity and 73.1% specificity. Conclusion: MBPS significantly increases in patients with newly diagnosed hypertensive pHPT. This increase in MBPS is closely associated with increased Ca levels. In patients with pHPT, lowering the Ca level below 10 mg/dL may have clinical implications. |
| first_indexed | 2024-03-11T23:43:26Z |
| format | Article |
| id | doaj.art-e818e0aa8cb041148b30fa504fba688d |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:26Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-e818e0aa8cb041148b30fa504fba688d2023-09-19T15:19:28ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062020-01-01421869210.1080/10641963.2019.15903881590388Morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium levelDerya Demirtas0Hilmi Erdem Sumbul1Abdullah Orhan Demirtas2Yahya Kemal Icen3Erdinc Gulumsek4Hasan Koca5Örsan Deniz Urgun6Mevlut Koc7University of Health Sciences- Adana Health Practices and Research CenterUniversity of Health Sciences- Adana Health Practices and Research CenterUniversity of Health Sciences - Adana Health Practices and Research CenterUniversity of Health Sciences - Adana Health Practices and Research CenterUniversity of Health Sciences- Adana Health Practices and Research CenterUniversity of Health Sciences - Adana Health Practices and Research CenterUniversity of Health Sciences - Adana Health Practices and Research CenterUniversity of Health Sciences - Adana Health Practices and Research CenterIntroduction: There is not enough data on the effects of primary hyperparathyroidism (pHPT) on morning blood pressure surge (MBPS) in the literature. We aimed to determine whether there was any change in MBPS value in patients with hypertensive pHPT and to determine the parameters related to MBPS. Method: 80 patients with newly diagnosed pHPT with hypertension (HT) and 80 controls with newly diagnosed hypertension were included. Routine laboratory examinations and ambulatory blood pressure monitoring (ABPM) were performed in all patients. Results: In patients with pHPT, blood urea nitrogen (BUN), triglyceride, hs-CRP, uric acid, serum calcium (Ca), parathormone (PTH), daytime SBP and MBPS levels are higher than others (p < 0.05). Body mass index (BMI) and Ca level were independently associated with MBPS. In patients with MBPS ≥ 25 mmHg, BMI, BUN, creatinine, uric acid, Ca and PTH levels were found to be higher than others. BMI values and Ca levels determine the patients with MBPS ≥ 25 mmHg (p < 0.05) independently. According to this analysis, increase in BMI (for each 1 unit) and Ca level (for each 0.1 mg/dL) was found to increase the probability of MBPS ≥ 25 mmHg by 17.8% and 7.7%, respectively. When the cut-off value for Ca was taken as 10 mg/dL, the patients with MBPS ≥ 25 mmHg were determined with 73.5% sensitivity and 73.1% specificity. Conclusion: MBPS significantly increases in patients with newly diagnosed hypertensive pHPT. This increase in MBPS is closely associated with increased Ca levels. In patients with pHPT, lowering the Ca level below 10 mg/dL may have clinical implications.http://dx.doi.org/10.1080/10641963.2019.1590388primary hyperparathyroidismmorning blood pressure surgeserum calcium level |
| spellingShingle | Derya Demirtas Hilmi Erdem Sumbul Abdullah Orhan Demirtas Yahya Kemal Icen Erdinc Gulumsek Hasan Koca Örsan Deniz Urgun Mevlut Koc Morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium level Clinical and Experimental Hypertension primary hyperparathyroidism morning blood pressure surge serum calcium level |
| title | Morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium level |
| title_full | Morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium level |
| title_fullStr | Morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium level |
| title_full_unstemmed | Morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium level |
| title_short | Morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium level |
| title_sort | morning blood pressure surge increases in patients with hypertensive primary hyperparathyroidism and is independently associated with serum calcium level |
| topic | primary hyperparathyroidism morning blood pressure surge serum calcium level |
| url | http://dx.doi.org/10.1080/10641963.2019.1590388 |
| work_keys_str_mv | AT deryademirtas morningbloodpressuresurgeincreasesinpatientswithhypertensiveprimaryhyperparathyroidismandisindependentlyassociatedwithserumcalciumlevel AT hilmierdemsumbul morningbloodpressuresurgeincreasesinpatientswithhypertensiveprimaryhyperparathyroidismandisindependentlyassociatedwithserumcalciumlevel AT abdullahorhandemirtas morningbloodpressuresurgeincreasesinpatientswithhypertensiveprimaryhyperparathyroidismandisindependentlyassociatedwithserumcalciumlevel AT yahyakemalicen morningbloodpressuresurgeincreasesinpatientswithhypertensiveprimaryhyperparathyroidismandisindependentlyassociatedwithserumcalciumlevel AT erdincgulumsek morningbloodpressuresurgeincreasesinpatientswithhypertensiveprimaryhyperparathyroidismandisindependentlyassociatedwithserumcalciumlevel AT hasankoca morningbloodpressuresurgeincreasesinpatientswithhypertensiveprimaryhyperparathyroidismandisindependentlyassociatedwithserumcalciumlevel AT orsandenizurgun morningbloodpressuresurgeincreasesinpatientswithhypertensiveprimaryhyperparathyroidismandisindependentlyassociatedwithserumcalciumlevel AT mevlutkoc morningbloodpressuresurgeincreasesinpatientswithhypertensiveprimaryhyperparathyroidismandisindependentlyassociatedwithserumcalciumlevel |