Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation
Objective: Iron overload (IO) is a common and life-threatening complication resulting from the therapy of AL and HCT patients. This study aimed to evaluate the prognostic value of 12 serum biomarkers of iron metabolism in pediatric patients treated for AL or undergoing HCT. Patients: Overall, 50 pat...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/4/1041 |
| _version_ | 1797621960086126592 |
|---|---|
| author | Jan Styczyński Artur Słomka Monika Łęcka Katarzyna Albrecht Michał Romiszewski Monika Pogorzała Małgorzata Kubicka Beata Kuryło-Rafińska Barbara Tejza Grażyna Gadomska Ewelina Kolańska-Dams Małgorzata Michalska Ewa Żekanowska |
| author_facet | Jan Styczyński Artur Słomka Monika Łęcka Katarzyna Albrecht Michał Romiszewski Monika Pogorzała Małgorzata Kubicka Beata Kuryło-Rafińska Barbara Tejza Grażyna Gadomska Ewelina Kolańska-Dams Małgorzata Michalska Ewa Żekanowska |
| author_sort | Jan Styczyński |
| collection | DOAJ |
| description | Objective: Iron overload (IO) is a common and life-threatening complication resulting from the therapy of AL and HCT patients. This study aimed to evaluate the prognostic value of 12 serum biomarkers of iron metabolism in pediatric patients treated for AL or undergoing HCT. Patients: Overall, 50 patients with AL after intensive treatment and 32 patients after HCT were prospectively included in the study. AL patients at diagnosis and healthy controls served as reference groups. Methods: The impact of the following 12 serum iron metabolism parameters on the outcome of AL/HCT patients was analyzed: iron, transferrin (Tf), total iron-binding capacity (TIBC), ferritin, ferritin heavy chains (FTH1), ferritin light chains (FTL), hepcidin, soluble hemojuvelin (sHJV), soluble ferroportin-1 (sFPN1), erythroferrone (ERFE), erythropoietin (EPO), and soluble transferrin receptor (sTfR). Results: With a median follow-up of 2.2 years, high levels of ferritin and low levels of sHJV had an adverse prognostic impact on OS and EFS in children after HCT. If these patients were combined with those with AL after intensive chemotherapy, the results were confirmed for OS and EFS both for ferritin and sHJV. Conclusions: Among the 12 analyzed serum parameters of iron metabolism, increased levels of ferritin and decreased levels of sHJV had an adverse prognostic impact on survival in children after HCT. More data are needed to clarify the relationship between ferritin, sHJV, and mortality of AL children after intensive chemotherapy, and more extensive prospective studies are required to prove sHJV predictivity. |
| first_indexed | 2024-03-11T09:03:29Z |
| format | Article |
| id | doaj.art-e81a75ffc45c4145a532d309fa7d7b91 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:03:29Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e81a75ffc45c4145a532d309fa7d7b912023-11-16T19:35:18ZengMDPI AGCancers2072-66942023-02-01154104110.3390/cancers15041041Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell TransplantationJan Styczyński0Artur Słomka1Monika Łęcka2Katarzyna Albrecht3Michał Romiszewski4Monika Pogorzała5Małgorzata Kubicka6Beata Kuryło-Rafińska7Barbara Tejza8Grażyna Gadomska9Ewelina Kolańska-Dams10Małgorzata Michalska11Ewa Żekanowska12Department of Pediatric Hematology and Oncology, Jurasz University Hospital, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Pathophysiology, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Pediatric Hematology and Oncology, Jurasz University Hospital, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Oncology, Hematology, Bone Marrow Transplantation and Pediatrics, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Oncology, Hematology, Bone Marrow Transplantation and Pediatrics, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Pediatric Hematology and Oncology, Jurasz University Hospital, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Pediatric Hematology and Oncology, Jurasz University Hospital, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Pediatric Hematology and Oncology, Jurasz University Hospital, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Pediatric Hematology and Oncology, Jurasz University Hospital, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Pathophysiology, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Pathophysiology, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Pathophysiology, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandDepartment of Pathophysiology, Collegium Medicum Nicolaus Copernicus University Torun, 85-094 Bydgoszcz, PolandObjective: Iron overload (IO) is a common and life-threatening complication resulting from the therapy of AL and HCT patients. This study aimed to evaluate the prognostic value of 12 serum biomarkers of iron metabolism in pediatric patients treated for AL or undergoing HCT. Patients: Overall, 50 patients with AL after intensive treatment and 32 patients after HCT were prospectively included in the study. AL patients at diagnosis and healthy controls served as reference groups. Methods: The impact of the following 12 serum iron metabolism parameters on the outcome of AL/HCT patients was analyzed: iron, transferrin (Tf), total iron-binding capacity (TIBC), ferritin, ferritin heavy chains (FTH1), ferritin light chains (FTL), hepcidin, soluble hemojuvelin (sHJV), soluble ferroportin-1 (sFPN1), erythroferrone (ERFE), erythropoietin (EPO), and soluble transferrin receptor (sTfR). Results: With a median follow-up of 2.2 years, high levels of ferritin and low levels of sHJV had an adverse prognostic impact on OS and EFS in children after HCT. If these patients were combined with those with AL after intensive chemotherapy, the results were confirmed for OS and EFS both for ferritin and sHJV. Conclusions: Among the 12 analyzed serum parameters of iron metabolism, increased levels of ferritin and decreased levels of sHJV had an adverse prognostic impact on survival in children after HCT. More data are needed to clarify the relationship between ferritin, sHJV, and mortality of AL children after intensive chemotherapy, and more extensive prospective studies are required to prove sHJV predictivity.https://www.mdpi.com/2072-6694/15/4/1041childrenacute leukemiahematopoietic cell transplantationiron metabolismferritinhemojuvelin |
| spellingShingle | Jan Styczyński Artur Słomka Monika Łęcka Katarzyna Albrecht Michał Romiszewski Monika Pogorzała Małgorzata Kubicka Beata Kuryło-Rafińska Barbara Tejza Grażyna Gadomska Ewelina Kolańska-Dams Małgorzata Michalska Ewa Żekanowska Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation Cancers children acute leukemia hematopoietic cell transplantation iron metabolism ferritin hemojuvelin |
| title | Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation |
| title_full | Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation |
| title_fullStr | Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation |
| title_full_unstemmed | Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation |
| title_short | Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation |
| title_sort | soluble hemojuvelin and ferritin potential prognostic markers in pediatric hematopoietic cell transplantation |
| topic | children acute leukemia hematopoietic cell transplantation iron metabolism ferritin hemojuvelin |
| url | https://www.mdpi.com/2072-6694/15/4/1041 |
| work_keys_str_mv | AT janstyczynski solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT artursłomka solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT monikałecka solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT katarzynaalbrecht solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT michałromiszewski solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT monikapogorzała solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT małgorzatakubicka solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT beatakuryłorafinska solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT barbaratejza solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT grazynagadomska solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT ewelinakolanskadams solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT małgorzatamichalska solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation AT ewazekanowska solublehemojuvelinandferritinpotentialprognosticmarkersinpediatrichematopoieticcelltransplantation |