The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature
Abstract Objective Radiation therapy is a mainstay in the treatment of numerous neoplasms. Numerous publications have reported good clinical outcomes for primary radiation therapy for Vestibular Schwannomas (VS). However, there are relatively few pathologic specimens of VSs available to evaluate pos...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-06-01
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| Series: | Laryngoscope Investigative Otolaryngology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/lio2.553 |
| _version_ | 1818435309582417920 |
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| author | Mark C. Dougherty Seiji B. Shibata Marlan R. Hansen |
| author_facet | Mark C. Dougherty Seiji B. Shibata Marlan R. Hansen |
| author_sort | Mark C. Dougherty |
| collection | DOAJ |
| description | Abstract Objective Radiation therapy is a mainstay in the treatment of numerous neoplasms. Numerous publications have reported good clinical outcomes for primary radiation therapy for Vestibular Schwannomas (VS). However, there are relatively few pathologic specimens of VSs available to evaluate post‐radiation, which has led to a relative dearth in research on the cellular mechanisms underlying the effects of radiation therapy on VSs. Methods Here we review the latest literature on the complex biological effects of radiation therapy on these benign tumors—including resistance to oxidative stress, mechanisms of DNA damage repair, alterations in normal growth factor pathways, changes in surrounding vasculature, and alterations in immune responses following radiation. Results Although VSs are highly radioresistant, radiotherapy is often successful in arresting their growth. Conclusion By better understanding the mechanisms underlying these effects, we could potentially harness such mechanisms in the future to potentiate the clinical effects of radiotherapy on VSs. Level of Evidence N/A. |
| first_indexed | 2024-12-14T16:50:50Z |
| format | Article |
| id | doaj.art-e81db2b543a04fa8884375da847c1027 |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-12-14T16:50:50Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-e81db2b543a04fa8884375da847c10272022-12-21T22:54:04ZengWileyLaryngoscope Investigative Otolaryngology2378-80382021-06-016345846810.1002/lio2.553The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literatureMark C. Dougherty0Seiji B. Shibata1Marlan R. Hansen2Department of Neurosurgery University of Iowa Hospitals & Clinics Iowa City Iowa USADepartment of Otolaryngology, Keck School of Medicine of USC University of Southern California Los Angeles California USADepartment of Otolaryngology—Head & Neck Surgery University of Iowa Hospitals & Clinics Iowa City Iowa USAAbstract Objective Radiation therapy is a mainstay in the treatment of numerous neoplasms. Numerous publications have reported good clinical outcomes for primary radiation therapy for Vestibular Schwannomas (VS). However, there are relatively few pathologic specimens of VSs available to evaluate post‐radiation, which has led to a relative dearth in research on the cellular mechanisms underlying the effects of radiation therapy on VSs. Methods Here we review the latest literature on the complex biological effects of radiation therapy on these benign tumors—including resistance to oxidative stress, mechanisms of DNA damage repair, alterations in normal growth factor pathways, changes in surrounding vasculature, and alterations in immune responses following radiation. Results Although VSs are highly radioresistant, radiotherapy is often successful in arresting their growth. Conclusion By better understanding the mechanisms underlying these effects, we could potentially harness such mechanisms in the future to potentiate the clinical effects of radiotherapy on VSs. Level of Evidence N/A.https://doi.org/10.1002/lio2.553radiation therapyradiobiologyradiosurgeryvestibular schwannoma |
| spellingShingle | Mark C. Dougherty Seiji B. Shibata Marlan R. Hansen The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature Laryngoscope Investigative Otolaryngology radiation therapy radiobiology radiosurgery vestibular schwannoma |
| title | The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature |
| title_full | The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature |
| title_fullStr | The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature |
| title_full_unstemmed | The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature |
| title_short | The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature |
| title_sort | biological underpinnings of radiation therapy for vestibular schwannomas review of the literature |
| topic | radiation therapy radiobiology radiosurgery vestibular schwannoma |
| url | https://doi.org/10.1002/lio2.553 |
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