Doxycycline-Induced Changes in Circulating MMP or TIMP2 Levels Are Not Associated with Skeletal-Related Event-Free or Overall Survival in Patients with Bone Metastases from Breast Cancer

Doxycycline-Induced Changes in Circulating MMP or TIMP2 Levels Are Not Associated with Skeletal-Related Event-Free or Overall Survival in Patients with Bone Metastases from Breast Cancer

Doxycycline is often used as a promoter of inducible gene expression in preclinical models; however, it can also have direct effects on tumor growth and survival. This is due in part to its ability to inhibit cell invasion and regulate matrix metalloproteinase (MMP) expression. Given that doxycyclin...

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Bibliographic Details
Main Authors: Huijun Zhao, Gregory Pond, Demetrios Simos, Zhou Wang, Susan Robertson, Gurmit Singh, Lisa Vandermeer, Mark Clemons, Christina Lynn Addison
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
doxycycline
breast cancer
bone metastasis
matrix metalloproteinase
MMP2
MMP9
Online Access:https://www.mdpi.com/2072-6694/15/3/571

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