A DSC Test for the Early Detection of Neoplastic Gastric Lesions in a Medium-Risk Gastric Cancer Area
In this study, we aimed to assess the accuracy of the proposed novel, noninvasive serum DSC test in predicting the risk of gastric cancer before the use of upper endoscopy. To validate the DSC test, we enrolled two series of individuals living in Veneto and Friuli-Venezia Giulia, Italy (n = 53 and n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3290 |
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| author | Valli De Re Stefano Realdon Roberto Vettori Alice Zaramella Stefania Maiero Ombretta Repetto Vincenzo Canzonieri Agostino Steffan Renato Cannizzaro |
| author_facet | Valli De Re Stefano Realdon Roberto Vettori Alice Zaramella Stefania Maiero Ombretta Repetto Vincenzo Canzonieri Agostino Steffan Renato Cannizzaro |
| author_sort | Valli De Re |
| collection | DOAJ |
| description | In this study, we aimed to assess the accuracy of the proposed novel, noninvasive serum DSC test in predicting the risk of gastric cancer before the use of upper endoscopy. To validate the DSC test, we enrolled two series of individuals living in Veneto and Friuli-Venezia Giulia, Italy (n = 53 and n = 113, respectively), who were referred for an endoscopy. The classification used for the DSC test to predict gastric cancer risk combines the coefficient of the patient’s age and sex and serum pepsinogen I and II, gastrin 17, and anti-<i>Helicobacter pylori</i> immunoglobulin G concentrations in two equations: Y1 and Y2. The coefficient of variables and the Y1 and Y2 cutoff points (>0.385 and >0.294, respectively) were extrapolated using regression analysis and an ROC curve analysis of two retrospective datasets (300 cases for the Y1 equation and 200 cases for the Y2 equation). The first dataset included individuals with autoimmune atrophic gastritis and first-degree relatives with gastric cancer; the second dataset included blood donors. Demographic data were collected; serum pepsinogen, gastrin G17, and anti-<i>Helicobacter pylori</i> IgG concentrations were assayed using an automatic Maglumi system. Gastroscopies were performed by gastroenterologists using an Olympus video endoscope with detailed photographic documentation during examinations. Biopsies were taken at five standardized mucosa sites and were assessed by a pathologist for diagnosis. The accuracy of the DSC test in predicting neoplastic gastric lesions was estimated to be 74.657% (65%CI; 67.333% to 81.079%). The DSC test was found to be a useful, noninvasive, and simple approach to predicting gastric cancer risk in a population with a medium risk of developing gastric cancer. |
| first_indexed | 2024-03-11T08:44:28Z |
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| id | doaj.art-e8203b7420da4802a906bcefb14f44b8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:44:28Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e8203b7420da4802a906bcefb14f44b82023-11-16T20:57:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244329010.3390/ijms24043290A DSC Test for the Early Detection of Neoplastic Gastric Lesions in a Medium-Risk Gastric Cancer AreaValli De Re0Stefano Realdon1Roberto Vettori2Alice Zaramella3Stefania Maiero4Ombretta Repetto5Vincenzo Canzonieri6Agostino Steffan7Renato Cannizzaro8Immunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano, CRO Aviano, National Cancer Institute, IRCCS, 33081 Aviano, ItalyOncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, ItalyImmunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano, CRO Aviano, National Cancer Institute, IRCCS, 33081 Aviano, ItalyGastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, 35128 Padua, ItalyOncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, ItalyImmunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano, CRO Aviano, National Cancer Institute, IRCCS, 33081 Aviano, ItalyPathology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, ItalyImmunopathology and Cancer Biomarkers, Centro di Riferimento Oncologico di Aviano, CRO Aviano, National Cancer Institute, IRCCS, 33081 Aviano, ItalyOncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, ItalyIn this study, we aimed to assess the accuracy of the proposed novel, noninvasive serum DSC test in predicting the risk of gastric cancer before the use of upper endoscopy. To validate the DSC test, we enrolled two series of individuals living in Veneto and Friuli-Venezia Giulia, Italy (n = 53 and n = 113, respectively), who were referred for an endoscopy. The classification used for the DSC test to predict gastric cancer risk combines the coefficient of the patient’s age and sex and serum pepsinogen I and II, gastrin 17, and anti-<i>Helicobacter pylori</i> immunoglobulin G concentrations in two equations: Y1 and Y2. The coefficient of variables and the Y1 and Y2 cutoff points (>0.385 and >0.294, respectively) were extrapolated using regression analysis and an ROC curve analysis of two retrospective datasets (300 cases for the Y1 equation and 200 cases for the Y2 equation). The first dataset included individuals with autoimmune atrophic gastritis and first-degree relatives with gastric cancer; the second dataset included blood donors. Demographic data were collected; serum pepsinogen, gastrin G17, and anti-<i>Helicobacter pylori</i> IgG concentrations were assayed using an automatic Maglumi system. Gastroscopies were performed by gastroenterologists using an Olympus video endoscope with detailed photographic documentation during examinations. Biopsies were taken at five standardized mucosa sites and were assessed by a pathologist for diagnosis. The accuracy of the DSC test in predicting neoplastic gastric lesions was estimated to be 74.657% (65%CI; 67.333% to 81.079%). The DSC test was found to be a useful, noninvasive, and simple approach to predicting gastric cancer risk in a population with a medium risk of developing gastric cancer.https://www.mdpi.com/1422-0067/24/4/3290gastric cancerpepsinogengastrin G17<i>Helicobacter pylori</i>screening |
| spellingShingle | Valli De Re Stefano Realdon Roberto Vettori Alice Zaramella Stefania Maiero Ombretta Repetto Vincenzo Canzonieri Agostino Steffan Renato Cannizzaro A DSC Test for the Early Detection of Neoplastic Gastric Lesions in a Medium-Risk Gastric Cancer Area International Journal of Molecular Sciences gastric cancer pepsinogen gastrin G17 <i>Helicobacter pylori</i> screening |
| title | A DSC Test for the Early Detection of Neoplastic Gastric Lesions in a Medium-Risk Gastric Cancer Area |
| title_full | A DSC Test for the Early Detection of Neoplastic Gastric Lesions in a Medium-Risk Gastric Cancer Area |
| title_fullStr | A DSC Test for the Early Detection of Neoplastic Gastric Lesions in a Medium-Risk Gastric Cancer Area |
| title_full_unstemmed | A DSC Test for the Early Detection of Neoplastic Gastric Lesions in a Medium-Risk Gastric Cancer Area |
| title_short | A DSC Test for the Early Detection of Neoplastic Gastric Lesions in a Medium-Risk Gastric Cancer Area |
| title_sort | dsc test for the early detection of neoplastic gastric lesions in a medium risk gastric cancer area |
| topic | gastric cancer pepsinogen gastrin G17 <i>Helicobacter pylori</i> screening |
| url | https://www.mdpi.com/1422-0067/24/4/3290 |
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