A Case of Pulmonary Nocardiosis Presenting with Multiple Cavitary Nodules in a Patient with Thrombocytopenia
Nocardiosis is an infrequent opportunistic infection that deserves more attention because of its increasing morbidity and high rate of misdiagnosis. Clinical and radiological manifestations as well as antibiograms of pulmonary nocardiosis are diverse. Herein, we report a patient with idiopathic thro...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Reports |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2571-841X/5/2/19 |
| _version_ | 1797482638662959104 |
|---|---|
| author | Fei Wang Qing Yu Jinye Zhu Chengli Que |
| author_facet | Fei Wang Qing Yu Jinye Zhu Chengli Que |
| author_sort | Fei Wang |
| collection | DOAJ |
| description | Nocardiosis is an infrequent opportunistic infection that deserves more attention because of its increasing morbidity and high rate of misdiagnosis. Clinical and radiological manifestations as well as antibiograms of pulmonary nocardiosis are diverse. Herein, we report a patient with idiopathic thrombocytopenia treated with glucocorticoids, which later presented with severe pulmonary infection with widely distributed nodules on chest computed tomography. Fungal infection or tuberculosis was under initial suspicion and microbiological tests of bronchoalveolar lavage fluid eventually yielded an affirmative result of <i>Nocardia cyriacigeorgica</i>. The patient responded in the beginning; however, therapeutic strategies had to be altered several times due to adverse events. The patient eventually ended up with radiographic resolution at the end of six months. We wish to share some experience in dealing with this disease especially recognizing pulmonary nocardiosis in computed tomography imaging. |
| first_indexed | 2024-03-09T22:36:17Z |
| format | Article |
| id | doaj.art-e821bd77d4034acdb6d28df31ccb7271 |
| institution | Directory Open Access Journal |
| issn | 2571-841X |
| language | English |
| last_indexed | 2024-03-09T22:36:17Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reports |
| spelling | doaj.art-e821bd77d4034acdb6d28df31ccb72712023-11-23T18:49:35ZengMDPI AGReports2571-841X2022-05-01521910.3390/reports5020019A Case of Pulmonary Nocardiosis Presenting with Multiple Cavitary Nodules in a Patient with ThrombocytopeniaFei Wang0Qing Yu1Jinye Zhu2Chengli Que3Department of Respiratory and Critical Care Medicine, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, ChinaDepartment of Respiratory and Critical Care Medicine, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, ChinaDepartment of Hematology, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, ChinaDepartment of Respiratory and Critical Care Medicine, Peking University First Hospital, 8 Xishiku Street, Beijing 100034, ChinaNocardiosis is an infrequent opportunistic infection that deserves more attention because of its increasing morbidity and high rate of misdiagnosis. Clinical and radiological manifestations as well as antibiograms of pulmonary nocardiosis are diverse. Herein, we report a patient with idiopathic thrombocytopenia treated with glucocorticoids, which later presented with severe pulmonary infection with widely distributed nodules on chest computed tomography. Fungal infection or tuberculosis was under initial suspicion and microbiological tests of bronchoalveolar lavage fluid eventually yielded an affirmative result of <i>Nocardia cyriacigeorgica</i>. The patient responded in the beginning; however, therapeutic strategies had to be altered several times due to adverse events. The patient eventually ended up with radiographic resolution at the end of six months. We wish to share some experience in dealing with this disease especially recognizing pulmonary nocardiosis in computed tomography imaging.https://www.mdpi.com/2571-841X/5/2/19nocardiosisimmunocompromisedradiological featuresantimicrobial treatment |
| spellingShingle | Fei Wang Qing Yu Jinye Zhu Chengli Que A Case of Pulmonary Nocardiosis Presenting with Multiple Cavitary Nodules in a Patient with Thrombocytopenia Reports nocardiosis immunocompromised radiological features antimicrobial treatment |
| title | A Case of Pulmonary Nocardiosis Presenting with Multiple Cavitary Nodules in a Patient with Thrombocytopenia |
| title_full | A Case of Pulmonary Nocardiosis Presenting with Multiple Cavitary Nodules in a Patient with Thrombocytopenia |
| title_fullStr | A Case of Pulmonary Nocardiosis Presenting with Multiple Cavitary Nodules in a Patient with Thrombocytopenia |
| title_full_unstemmed | A Case of Pulmonary Nocardiosis Presenting with Multiple Cavitary Nodules in a Patient with Thrombocytopenia |
| title_short | A Case of Pulmonary Nocardiosis Presenting with Multiple Cavitary Nodules in a Patient with Thrombocytopenia |
| title_sort | case of pulmonary nocardiosis presenting with multiple cavitary nodules in a patient with thrombocytopenia |
| topic | nocardiosis immunocompromised radiological features antimicrobial treatment |
| url | https://www.mdpi.com/2571-841X/5/2/19 |
| work_keys_str_mv | AT feiwang acaseofpulmonarynocardiosispresentingwithmultiplecavitarynodulesinapatientwiththrombocytopenia AT qingyu acaseofpulmonarynocardiosispresentingwithmultiplecavitarynodulesinapatientwiththrombocytopenia AT jinyezhu acaseofpulmonarynocardiosispresentingwithmultiplecavitarynodulesinapatientwiththrombocytopenia AT chenglique acaseofpulmonarynocardiosispresentingwithmultiplecavitarynodulesinapatientwiththrombocytopenia AT feiwang caseofpulmonarynocardiosispresentingwithmultiplecavitarynodulesinapatientwiththrombocytopenia AT qingyu caseofpulmonarynocardiosispresentingwithmultiplecavitarynodulesinapatientwiththrombocytopenia AT jinyezhu caseofpulmonarynocardiosispresentingwithmultiplecavitarynodulesinapatientwiththrombocytopenia AT chenglique caseofpulmonarynocardiosispresentingwithmultiplecavitarynodulesinapatientwiththrombocytopenia |