IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATION
Aim. To compare effects of different medication therapy schedules on parameters of systolic and diastolic function of the left (LV) and right (RV) ventricles in patients with ischemic heart disease (CHD) after primary revascularization of myocardium (PPCI).Material and metods. The study was performe...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2014-10-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/54 |
| _version_ | 1797882568015609856 |
|---|---|
| author | N. V. Drobotya A. A. Dyuzhikov E. A. Kudryashova D. V. Vasilikhina V. V. Kaltykova |
| author_facet | N. V. Drobotya A. A. Dyuzhikov E. A. Kudryashova D. V. Vasilikhina V. V. Kaltykova |
| author_sort | N. V. Drobotya |
| collection | DOAJ |
| description | Aim. To compare effects of different medication therapy schedules on parameters of systolic and diastolic function of the left (LV) and right (RV) ventricles in patients with ischemic heart disease (CHD) after primary revascularization of myocardium (PPCI).Material and metods. The study was performed on two groups of CHD patients (n=32 and n=30, resp.) before and after PPCI. Systolic and diastolic function were assessed by ultrasound methods including doppler. In the 1st group during post-surgery period due to impossibility to titrate dosage of β-adrenoblokers and, respectively, achievement of CHD target heartrate, standard therapy was improved by ivabradin in dose 10-15 mg/day during 3 months.Results. Before operation in CHD patients’ diastolic dysfunction of LV and RV prevailed. PPCI and consequent medication therapy led to improve of systolic function of the LV and RV in both groups, however in the group additionally received ivabradin dynamic of the parameters was more prominet. In the 1st group, in contrast to 2st, also there was normalization of diastolic function of both ventricles.Conclusion. Adding of ivabradine to standard therapy of CHD patients after PPCI fulfills the efficacy for systolic LV and RV function and leads to normalization of their diastolic function. |
| first_indexed | 2024-04-10T03:36:46Z |
| format | Article |
| id | doaj.art-e8226e88f58341d18fff2ed2d8ea55f9 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:36:46Z |
| publishDate | 2014-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-e8226e88f58341d18fff2ed2d8ea55f92023-03-13T07:23:23Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252014-10-01135455110.15829/1728-8800-2014-5-45-5154IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATIONN. V. Drobotya0A. A. Dyuzhikov1E. A. Kudryashova2D. V. Vasilikhina3V. V. Kaltykova4ГБОУ ВПО “Ростовский государственный медицинский университет” Минздрава РоссииЦентр кардиологии и сердечно-сосудистой хирургии государственного бюджетного учреждения Ростовский области “Ростовская областная клиническая больница”, Ростов-на-ДонуЦентр кардиологии и сердечно-сосудистой хирургии государственного бюджетного учреждения Ростовский области “Ростовская областная клиническая больница”, Ростов-на-ДонуЦентр кардиологии и сердечно-сосудистой хирургии государственного бюджетного учреждения Ростовский области “Ростовская областная клиническая больница”, Ростов-на-ДонуГБОУ ВПО “Ростовский государственный медицинский университет” Минздрава РоссииAim. To compare effects of different medication therapy schedules on parameters of systolic and diastolic function of the left (LV) and right (RV) ventricles in patients with ischemic heart disease (CHD) after primary revascularization of myocardium (PPCI).Material and metods. The study was performed on two groups of CHD patients (n=32 and n=30, resp.) before and after PPCI. Systolic and diastolic function were assessed by ultrasound methods including doppler. In the 1st group during post-surgery period due to impossibility to titrate dosage of β-adrenoblokers and, respectively, achievement of CHD target heartrate, standard therapy was improved by ivabradin in dose 10-15 mg/day during 3 months.Results. Before operation in CHD patients’ diastolic dysfunction of LV and RV prevailed. PPCI and consequent medication therapy led to improve of systolic function of the LV and RV in both groups, however in the group additionally received ivabradin dynamic of the parameters was more prominet. In the 1st group, in contrast to 2st, also there was normalization of diastolic function of both ventricles.Conclusion. Adding of ivabradine to standard therapy of CHD patients after PPCI fulfills the efficacy for systolic LV and RV function and leads to normalization of their diastolic function.https://cardiovascular.elpub.ru/jour/article/view/54ишемическая болезнь сердцапрямая реваскуляризация миокардаивабрадинсистолическая и диастолическая функция левого и правого желудочков |
| spellingShingle | N. V. Drobotya A. A. Dyuzhikov E. A. Kudryashova D. V. Vasilikhina V. V. Kaltykova IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATION Кардиоваскулярная терапия и профилактика ишемическая болезнь сердца прямая реваскуляризация миокарда ивабрадин систолическая и диастолическая функция левого и правого желудочков |
| title | IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATION |
| title_full | IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATION |
| title_fullStr | IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATION |
| title_full_unstemmed | IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATION |
| title_short | IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATION |
| title_sort | ivabradine influence on systolic and diastolic function of heart ventricles in patients with ischemic heart disease after primary revascularization |
| topic | ишемическая болезнь сердца прямая реваскуляризация миокарда ивабрадин систолическая и диастолическая функция левого и правого желудочков |
| url | https://cardiovascular.elpub.ru/jour/article/view/54 |
| work_keys_str_mv | AT nvdrobotya ivabradineinfluenceonsystolicanddiastolicfunctionofheartventriclesinpatientswithischemicheartdiseaseafterprimaryrevascularization AT aadyuzhikov ivabradineinfluenceonsystolicanddiastolicfunctionofheartventriclesinpatientswithischemicheartdiseaseafterprimaryrevascularization AT eakudryashova ivabradineinfluenceonsystolicanddiastolicfunctionofheartventriclesinpatientswithischemicheartdiseaseafterprimaryrevascularization AT dvvasilikhina ivabradineinfluenceonsystolicanddiastolicfunctionofheartventriclesinpatientswithischemicheartdiseaseafterprimaryrevascularization AT vvkaltykova ivabradineinfluenceonsystolicanddiastolicfunctionofheartventriclesinpatientswithischemicheartdiseaseafterprimaryrevascularization |