The combined effects of hierarchical scaffolds and mechanical stimuli on ex vivo expansion of haematopoietic stem/progenitor cells

The combined effects of hierarchical scaffolds and mechanical stimuli on ex vivo expansion of haematopoietic stem/progenitor cells

We describe the ex vivo expansion of haematopoietic stem/progenitor cells (HSPCs) with consideration of their eventual in-vivo niche. We firstly fabricated hierarchically structured scaffolds (lattices derived via three-dimensional plotting combined with electrospun submicron fibers coated with vitr...

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Bibliographic Details
Main Authors: Ji Eun Kim, Eun Jin Lee, Yanru Wu, Yun Gyeong Kang, Jung-Woog Shin
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Haematopoietic stem/progenitor cells
ex vivo expansion
3D hierarchical scaffold
mechanical stimuli
stem cell niche
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1573180

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