Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation
Objective To investigate the efficiency and safety of the infusion of umbilical cord mesenchymal stromal cells (UCMSCs) for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods Clinical data of patients with hemorrhages cystitis after allo-HSCT in our me...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Third Military Medical University
2019-12-01
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| Series: | Di-san junyi daxue xuebao |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/201907007.htm |
| _version_ | 1831649337006882816 |
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| author | LIU Hongyun CHEN Guo ZENG Yunjing ZHANG Xi GAO Li |
| author_facet | LIU Hongyun CHEN Guo ZENG Yunjing ZHANG Xi GAO Li |
| author_sort | LIU Hongyun |
| collection | DOAJ |
| description | Objective To investigate the efficiency and safety of the infusion of umbilical cord mesenchymal stromal cells (UCMSCs) for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods Clinical data of patients with hemorrhages cystitis after allo-HSCT in our medical center from January 2014 to December 2018 were collected and analyzed retrospectively in this study. The duration of hemorrhagic cystitis, response rate and pain scores were compared between the patients undergoing UCMSCs infusion (n=28) and those without (n=24). The safety of the infusion was also observed. Results The UCMSCs infusion group had significantly higher overall response rate (100.0% vs 45.8%, P < 0.05), shorter median time of pain disappearance (20.6±13.5 vs 33.9±21.7 d, P < 0.05), and shorter duration of hematuria macroscopically (26.3±14.8 vs 38.9±24.0 d, P < 0.05) and microscopically (31.3±13.6 vs 48.9±22.0 d, P < 0.05) when compared the infusion group. Infusion of UCMSCs had no effect on the infection rates of blood cytomegalovirus and urinary BK virus. Conclusion Infusion of UCMSCs can significantly shorten the course of hemorrhagic cystitis, reduce pain, improve general prognosis, and have no side effect in the patients after allo-HSCT |
| first_indexed | 2024-12-19T14:49:00Z |
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| id | doaj.art-e8236724d2a74ca996108b75c7afbcb8 |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-19T14:49:00Z |
| publishDate | 2019-12-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-e8236724d2a74ca996108b75c7afbcb82022-12-21T20:16:53ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042019-12-0141232296230010.16016/j.1000-5404.201907007Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantationLIU Hongyun0CHEN Guo1ZENG Yunjing2ZHANG Xi3GAO Li4State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China State Key Laboratory of Trauma, Burns and Combined Injury, Medical Center of Hematology, PLA Center for Hematology, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, China Objective To investigate the efficiency and safety of the infusion of umbilical cord mesenchymal stromal cells (UCMSCs) for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods Clinical data of patients with hemorrhages cystitis after allo-HSCT in our medical center from January 2014 to December 2018 were collected and analyzed retrospectively in this study. The duration of hemorrhagic cystitis, response rate and pain scores were compared between the patients undergoing UCMSCs infusion (n=28) and those without (n=24). The safety of the infusion was also observed. Results The UCMSCs infusion group had significantly higher overall response rate (100.0% vs 45.8%, P < 0.05), shorter median time of pain disappearance (20.6±13.5 vs 33.9±21.7 d, P < 0.05), and shorter duration of hematuria macroscopically (26.3±14.8 vs 38.9±24.0 d, P < 0.05) and microscopically (31.3±13.6 vs 48.9±22.0 d, P < 0.05) when compared the infusion group. Infusion of UCMSCs had no effect on the infection rates of blood cytomegalovirus and urinary BK virus. Conclusion Infusion of UCMSCs can significantly shorten the course of hemorrhagic cystitis, reduce pain, improve general prognosis, and have no side effect in the patients after allo-HSCThttp://aammt.tmmu.edu.cn/Upload/rhtml/201907007.htmhemorrhagic cystitisumbilical cord mesenchymal stromal cellsallogeneic hematopoietic stem cell transplantationcytomegalovirusbk virus |
| spellingShingle | LIU Hongyun CHEN Guo ZENG Yunjing ZHANG Xi GAO Li Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation Di-san junyi daxue xuebao hemorrhagic cystitis umbilical cord mesenchymal stromal cells allogeneic hematopoietic stem cell transplantation cytomegalovirus bk virus |
| title | Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation |
| title_full | Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation |
| title_fullStr | Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation |
| title_full_unstemmed | Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation |
| title_short | Efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation |
| title_sort | efficiency and safety of umbilical cord mesenchymal stromal cell infusion in treatment of hemorrhagic cystitis after allogenic hematopoietic stem cell transplantation |
| topic | hemorrhagic cystitis umbilical cord mesenchymal stromal cells allogeneic hematopoietic stem cell transplantation cytomegalovirus bk virus |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/201907007.htm |
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