Lipid Interactions Between Flaviviruses and Mosquito Vectors
Mosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations. In absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requir...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.763195/full |
| _version_ | 1818899470483456000 |
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| author | Thomas Vial Thomas Vial Guillaume Marti Guillaume Marti Dorothée Missé Julien Pompon |
| author_facet | Thomas Vial Thomas Vial Guillaume Marti Guillaume Marti Dorothée Missé Julien Pompon |
| author_sort | Thomas Vial |
| collection | DOAJ |
| description | Mosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations. In absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requirements in mosquitoes may hold the key to new intervention strategies. Development of metabolomics in the last decade opened a new field of research: mosquito metabolomics. It is now clear that flaviviruses rely on mosquito lipids, especially phospholipids, for their cellular cycle and propagation. Here, we review the biosyntheses of, biochemical properties of and flaviviral interactions with mosquito phospholipids. Phospholipids are structural lipids with a polar headgroup and apolar acyl chains, enabling the formation of lipid bilayer that form plasma- and endomembranes. Phospholipids are mostly synthesized through the de novo pathway and remodeling cycle. Variations in headgroup and acyl chains influence phospholipid physicochemical properties and consequently the membrane behavior. Flaviviruses interact with cellular membranes at every step of their cellular cycle. Recent evidence demonstrates that flaviviruses reconfigure the phospholipidome in mosquitoes by regulating phospholipid syntheses to increase virus multiplication. Identifying the phospholipids involved and understanding how flaviviruses regulate these in mosquitoes is required to design new interventions. |
| first_indexed | 2024-12-19T19:48:29Z |
| format | Article |
| id | doaj.art-e824cbe559f748899fcbf69565355dec |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-19T19:48:29Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-e824cbe559f748899fcbf69565355dec2022-12-21T20:08:04ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-11-011210.3389/fphys.2021.763195763195Lipid Interactions Between Flaviviruses and Mosquito VectorsThomas Vial0Thomas Vial1Guillaume Marti2Guillaume Marti3Dorothée Missé4Julien Pompon5Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, SingaporeUMR 152 PHARMADEV-IRD, Université Paul Sabatier, Toulouse, FranceLRSV (UMR 5546), CNRS, Université de Toulouse, Toulouse, FranceMetaboHUB, National Infrastructure of Metabolomics and Fluxomics, Toulouse, FranceMIVEGEC, Université Montpellier, IRD, CNRS, Montpellier, FranceMIVEGEC, Université Montpellier, IRD, CNRS, Montpellier, FranceMosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations. In absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requirements in mosquitoes may hold the key to new intervention strategies. Development of metabolomics in the last decade opened a new field of research: mosquito metabolomics. It is now clear that flaviviruses rely on mosquito lipids, especially phospholipids, for their cellular cycle and propagation. Here, we review the biosyntheses of, biochemical properties of and flaviviral interactions with mosquito phospholipids. Phospholipids are structural lipids with a polar headgroup and apolar acyl chains, enabling the formation of lipid bilayer that form plasma- and endomembranes. Phospholipids are mostly synthesized through the de novo pathway and remodeling cycle. Variations in headgroup and acyl chains influence phospholipid physicochemical properties and consequently the membrane behavior. Flaviviruses interact with cellular membranes at every step of their cellular cycle. Recent evidence demonstrates that flaviviruses reconfigure the phospholipidome in mosquitoes by regulating phospholipid syntheses to increase virus multiplication. Identifying the phospholipids involved and understanding how flaviviruses regulate these in mosquitoes is required to design new interventions.https://www.frontiersin.org/articles/10.3389/fphys.2021.763195/fullmosquitoflavivirusphospholipidstransmissionmetabolomics |
| spellingShingle | Thomas Vial Thomas Vial Guillaume Marti Guillaume Marti Dorothée Missé Julien Pompon Lipid Interactions Between Flaviviruses and Mosquito Vectors Frontiers in Physiology mosquito flavivirus phospholipids transmission metabolomics |
| title | Lipid Interactions Between Flaviviruses and Mosquito Vectors |
| title_full | Lipid Interactions Between Flaviviruses and Mosquito Vectors |
| title_fullStr | Lipid Interactions Between Flaviviruses and Mosquito Vectors |
| title_full_unstemmed | Lipid Interactions Between Flaviviruses and Mosquito Vectors |
| title_short | Lipid Interactions Between Flaviviruses and Mosquito Vectors |
| title_sort | lipid interactions between flaviviruses and mosquito vectors |
| topic | mosquito flavivirus phospholipids transmission metabolomics |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.763195/full |
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