Dataset of RNA-Seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifers
Herein, we present a dataset based on the RNA-Seq analysis of liver tissue from bovine female fetuses at day 83 of gestation. The findings were reported in the main article, “Periconceptual maternal nutrition affects fetal liver programming of energy- and lipid-related genes” [1]. These data were ge...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Data in Brief |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340923002925 |
| _version_ | 1797798106383777792 |
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| author | Wellison J.S. Diniz Alison K. Ward Kacie L. McCarthy Cierrah J. Kassetas Friederike Baumgaertner Lawrence P. Reynolds Pawel P. Borowicz Kevin K. Sedivec James D. Kirsch Sheri T. Dorsam Tammi L. Neville J. Chris Forcherio Ronald Scott Joel S. Caton Carl R. Dahlen |
| author_facet | Wellison J.S. Diniz Alison K. Ward Kacie L. McCarthy Cierrah J. Kassetas Friederike Baumgaertner Lawrence P. Reynolds Pawel P. Borowicz Kevin K. Sedivec James D. Kirsch Sheri T. Dorsam Tammi L. Neville J. Chris Forcherio Ronald Scott Joel S. Caton Carl R. Dahlen |
| author_sort | Wellison J.S. Diniz |
| collection | DOAJ |
| description | Herein, we present a dataset based on the RNA-Seq analysis of liver tissue from bovine female fetuses at day 83 of gestation. The findings were reported in the main article, “Periconceptual maternal nutrition affects fetal liver programming of energy- and lipid-related genes” [1]. These data were generated to investigate the effects of periconceptual maternal vitamin and mineral supplementation and rates of body weight gain on the transcript abundance of genes associated with fetal hepatic metabolism and function. To this end, crossbred Angus beef heifers (n = 35) were randomly assigned to 1 of 4 treatments in a 2 × 2 factorial design. The main effects tested were vitamin and mineral supplementation (VTM or NoVTM – at least 71 days pre-breeding to day 83 of gestation) and rate of weight gain (low (LG – 0.28 kg/d) or moderate (MG – 0.79 kg/d) – from breeding to day 83). The fetal liver was collected on day 83 ± 0.27 of gestation. After total RNA isolation and quality control, strand-specific RNA libraries were prepared and sequenced on the Illumina® NovaSeq 6000 platform to generate paired-end 150-bp reads. After read mapping and counting, differential expression analysis was performed with edgeR. We identified 591 unique differentially expressed genes across all six vitamin-gain contrasts (FDR ≤ 0.1). To our knowledge, this is the first dataset investigating the fetal liver transcriptome in response to periconceptual maternal vitamin and mineral supplementation and/or the rate of weight gain. The data described in this article provides genes and molecular pathways differentially programming liver development and function. |
| first_indexed | 2024-03-13T03:58:31Z |
| format | Article |
| id | doaj.art-e82583cf510a45488989d0595dd2ff40 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-03-13T03:58:31Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-e82583cf510a45488989d0595dd2ff402023-06-22T05:03:51ZengElsevierData in Brief2352-34092023-06-0148109173Dataset of RNA-Seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifersWellison J.S. Diniz0Alison K. Ward1Kacie L. McCarthy2Cierrah J. Kassetas3Friederike Baumgaertner4Lawrence P. Reynolds5Pawel P. Borowicz6Kevin K. Sedivec7James D. Kirsch8Sheri T. Dorsam9Tammi L. Neville10J. Chris Forcherio11Ronald Scott12Joel S. Caton13Carl R. Dahlen14Department of Animal Sciences, Auburn University, Auburn, AL 36849, United States; Corresponding author.Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesDepartment of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68583, United StatesDepartment of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesDepartment of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesDepartment of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesDepartment of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesCentral Grasslands Research and Extension Center, North Dakota State University, Streeter, ND 58483, United StatesDepartment of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesDepartment of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesDepartment of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesPurina Animal Nutrition LLC, Gray Summit, MO 63039, United StatesPurina Animal Nutrition LLC, Gray Summit, MO 63039, United StatesDepartment of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesDepartment of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United StatesHerein, we present a dataset based on the RNA-Seq analysis of liver tissue from bovine female fetuses at day 83 of gestation. The findings were reported in the main article, “Periconceptual maternal nutrition affects fetal liver programming of energy- and lipid-related genes” [1]. These data were generated to investigate the effects of periconceptual maternal vitamin and mineral supplementation and rates of body weight gain on the transcript abundance of genes associated with fetal hepatic metabolism and function. To this end, crossbred Angus beef heifers (n = 35) were randomly assigned to 1 of 4 treatments in a 2 × 2 factorial design. The main effects tested were vitamin and mineral supplementation (VTM or NoVTM – at least 71 days pre-breeding to day 83 of gestation) and rate of weight gain (low (LG – 0.28 kg/d) or moderate (MG – 0.79 kg/d) – from breeding to day 83). The fetal liver was collected on day 83 ± 0.27 of gestation. After total RNA isolation and quality control, strand-specific RNA libraries were prepared and sequenced on the Illumina® NovaSeq 6000 platform to generate paired-end 150-bp reads. After read mapping and counting, differential expression analysis was performed with edgeR. We identified 591 unique differentially expressed genes across all six vitamin-gain contrasts (FDR ≤ 0.1). To our knowledge, this is the first dataset investigating the fetal liver transcriptome in response to periconceptual maternal vitamin and mineral supplementation and/or the rate of weight gain. The data described in this article provides genes and molecular pathways differentially programming liver development and function.http://www.sciencedirect.com/science/article/pii/S2352340923002925Fetal developmentHepatic transcriptomeLiverMineralsPrenatal dietVitamins |
| spellingShingle | Wellison J.S. Diniz Alison K. Ward Kacie L. McCarthy Cierrah J. Kassetas Friederike Baumgaertner Lawrence P. Reynolds Pawel P. Borowicz Kevin K. Sedivec James D. Kirsch Sheri T. Dorsam Tammi L. Neville J. Chris Forcherio Ronald Scott Joel S. Caton Carl R. Dahlen Dataset of RNA-Seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifers Data in Brief Fetal development Hepatic transcriptome Liver Minerals Prenatal diet Vitamins |
| title | Dataset of RNA-Seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifers |
| title_full | Dataset of RNA-Seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifers |
| title_fullStr | Dataset of RNA-Seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifers |
| title_full_unstemmed | Dataset of RNA-Seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifers |
| title_short | Dataset of RNA-Seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifers |
| title_sort | dataset of rna seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifers |
| topic | Fetal development Hepatic transcriptome Liver Minerals Prenatal diet Vitamins |
| url | http://www.sciencedirect.com/science/article/pii/S2352340923002925 |
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