Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer
Due to the heterogeneity of tumour mass segmentation methods and lack of consensus, our study evaluated the prognostic value of pretherapeutic positron emission tomography with fluorodeoxyglucose (FDG-PET) metabolic parameters using different segmentation methods in patients with localized anal squa...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/6/1512 |
| _version_ | 1797565750281502720 |
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| author | Maelle Le Thiec Aude Testard Ludovic Ferrer Camille Guillerminet Olivier Morel Bruno Maucherat Daniela Rusu Sylvie Girault Marie Lacombe Hadji Hamidou Véronique Guérin Meyer Emmanuel Rio Sandrine Hiret Françoise Kraeber-Bodéré Loïc Campion Caroline Rousseau |
| author_facet | Maelle Le Thiec Aude Testard Ludovic Ferrer Camille Guillerminet Olivier Morel Bruno Maucherat Daniela Rusu Sylvie Girault Marie Lacombe Hadji Hamidou Véronique Guérin Meyer Emmanuel Rio Sandrine Hiret Françoise Kraeber-Bodéré Loïc Campion Caroline Rousseau |
| author_sort | Maelle Le Thiec |
| collection | DOAJ |
| description | Due to the heterogeneity of tumour mass segmentation methods and lack of consensus, our study evaluated the prognostic value of pretherapeutic positron emission tomography with fluorodeoxyglucose (FDG-PET) metabolic parameters using different segmentation methods in patients with localized anal squamous cell carcinoma (SCC). Eighty-one patients with FDG-PET before radiochemotherapy were retrospectively analyzed. Semiquantitative data were measured with three fixed thresholds (35%, 41% and 50% of Maximum Standardized Uptake Value (SUVmax)) and four segmentation methods based on iterative approaches (Black, Adaptive, Nestle and Fitting). Metabolic volumes of primary anal tumour (P-MTV) and total tumour load (T-MTV: P-MTV+ lymph node MTV) were calculated. The primary endpoint was event-free survival (EFS). Seven multivariate models were created to compare FDG-PET tumour volumes prognostic impact. For all segmentation thresholds, PET metabolic volume parameters were independent prognostic factor and T-MTV variable was consistently better associated with EFS than P-MTV. Patient’s sex was an independent variable and significantly correlated with EFS. With fixed threshold segmentation methods, 35% of SUVmax threshold seemed better correlated with EFS and the best cut-off for discrimination between a low and high risk of event occurrence was 40 cm<sup>3</sup>. Determination of T-MTV by FDG-PET using fixed threshold segmentation is useful for predicting EFS for primary anal SCC. If these data are confirmed in larger studies, FDG-PET could contribute to individualized patient therapies. |
| first_indexed | 2024-03-10T19:16:28Z |
| format | Article |
| id | doaj.art-e825956f2cd6438997af480e34ba9e16 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:16:28Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e825956f2cd6438997af480e34ba9e162023-11-20T03:21:19ZengMDPI AGCancers2072-66942020-06-01126151210.3390/cancers12061512Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal CancerMaelle Le Thiec0Aude Testard1Ludovic Ferrer2Camille Guillerminet3Olivier Morel4Bruno Maucherat5Daniela Rusu6Sylvie Girault7Marie Lacombe8Hadji Hamidou9Véronique Guérin Meyer10Emmanuel Rio11Sandrine Hiret12Françoise Kraeber-Bodéré13Loïc Campion14Caroline Rousseau15Nuclear Medicine Unit, ICO Cancer Center, 44805 Saint Herblain, FranceNuclear Medicine Unit, ICO Cancer Center, 49055 Angers, FranceMedical Physics Unit, ICO Cancer Center, 44805 Saint Herblain, FranceMedical Physics Unit, ICO Cancer Center, 49055 Angers, FranceNuclear Medicine Unit, ICO Cancer Center, 49055 Angers, FranceNuclear Medicine Unit, ICO Cancer Center, 44805 Saint Herblain, FranceNuclear Medicine Unit, ICO Cancer Center, 44805 Saint Herblain, FranceNuclear Medicine Unit, ICO Cancer Center, 49055 Angers, FranceNuclear Medicine Unit, ICO Cancer Center, 49055 Angers, FranceRadiation Oncology Unit, ICO Cancer Center, 49055 Angers, FranceMedical Oncology Unit, ICO Cancer Center, 49055 Angers, FranceRadiation Oncology Unit, ICO Cancer Center, 44805 Saint Herblain, FranceMedical Oncology Unit, ICO Cancer Center, 44805 Saint Herblain, FranceNuclear Medicine Unit, ICO Cancer Center, 44805 Saint Herblain, FranceCRCINA, University of Nantes and Angers, INSERM UMR1232, CNRS-ERL6001, 49055 Angers, FranceNuclear Medicine Unit, ICO Cancer Center, 44805 Saint Herblain, FranceDue to the heterogeneity of tumour mass segmentation methods and lack of consensus, our study evaluated the prognostic value of pretherapeutic positron emission tomography with fluorodeoxyglucose (FDG-PET) metabolic parameters using different segmentation methods in patients with localized anal squamous cell carcinoma (SCC). Eighty-one patients with FDG-PET before radiochemotherapy were retrospectively analyzed. Semiquantitative data were measured with three fixed thresholds (35%, 41% and 50% of Maximum Standardized Uptake Value (SUVmax)) and four segmentation methods based on iterative approaches (Black, Adaptive, Nestle and Fitting). Metabolic volumes of primary anal tumour (P-MTV) and total tumour load (T-MTV: P-MTV+ lymph node MTV) were calculated. The primary endpoint was event-free survival (EFS). Seven multivariate models were created to compare FDG-PET tumour volumes prognostic impact. For all segmentation thresholds, PET metabolic volume parameters were independent prognostic factor and T-MTV variable was consistently better associated with EFS than P-MTV. Patient’s sex was an independent variable and significantly correlated with EFS. With fixed threshold segmentation methods, 35% of SUVmax threshold seemed better correlated with EFS and the best cut-off for discrimination between a low and high risk of event occurrence was 40 cm<sup>3</sup>. Determination of T-MTV by FDG-PET using fixed threshold segmentation is useful for predicting EFS for primary anal SCC. If these data are confirmed in larger studies, FDG-PET could contribute to individualized patient therapies.https://www.mdpi.com/2072-6694/12/6/1512anal cancerFDG-PETprognosismetabolic tumour volume |
| spellingShingle | Maelle Le Thiec Aude Testard Ludovic Ferrer Camille Guillerminet Olivier Morel Bruno Maucherat Daniela Rusu Sylvie Girault Marie Lacombe Hadji Hamidou Véronique Guérin Meyer Emmanuel Rio Sandrine Hiret Françoise Kraeber-Bodéré Loïc Campion Caroline Rousseau Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer Cancers anal cancer FDG-PET prognosis metabolic tumour volume |
| title | Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer |
| title_full | Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer |
| title_fullStr | Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer |
| title_full_unstemmed | Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer |
| title_short | Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer |
| title_sort | prognostic impact of pretherapeutic fdg pet in localized anal cancer |
| topic | anal cancer FDG-PET prognosis metabolic tumour volume |
| url | https://www.mdpi.com/2072-6694/12/6/1512 |
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