Host populations, challenges, and commercialization of cryptococcal vaccines
Vaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral infections, including the most recent Coronavirus Dise...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-02-01
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| Series: | PLoS Pathogens |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910758/?tool=EBI |
| _version_ | 1811166153348743168 |
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| author | Maurizio Del Poeta Floyd L. Wormley Xiaorong Lin |
| author_facet | Maurizio Del Poeta Floyd L. Wormley Xiaorong Lin |
| author_sort | Maurizio Del Poeta |
| collection | DOAJ |
| description | Vaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral infections, including the most recent Coronavirus Disease 2019 (COVID-19) pandemic. However, there remains no vaccine that is clinically available to treat or prevent invasive fungal diseases, including cryptococcal meningoencephalitis. This fungal disease is uniformly fatal without treatment and has a global mortality rate of over 70%. Despite a dire need for an effective cryptococcal vaccine, there are many scientific and economic challenges to overcome prior to making it a reality. Here, we discuss some of these challenges as well as steps that the community is taking for commercialization of effective cryptococcal vaccines. |
| first_indexed | 2024-04-10T15:47:58Z |
| format | Article |
| id | doaj.art-e826733765e04bd281c15a8518f0af60 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-04-10T15:47:58Z |
| publishDate | 2023-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-e826733765e04bd281c15a8518f0af602023-02-12T05:30:46ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742023-02-01192Host populations, challenges, and commercialization of cryptococcal vaccinesMaurizio Del PoetaFloyd L. WormleyXiaorong LinVaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral infections, including the most recent Coronavirus Disease 2019 (COVID-19) pandemic. However, there remains no vaccine that is clinically available to treat or prevent invasive fungal diseases, including cryptococcal meningoencephalitis. This fungal disease is uniformly fatal without treatment and has a global mortality rate of over 70%. Despite a dire need for an effective cryptococcal vaccine, there are many scientific and economic challenges to overcome prior to making it a reality. Here, we discuss some of these challenges as well as steps that the community is taking for commercialization of effective cryptococcal vaccines.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910758/?tool=EBI |
| spellingShingle | Maurizio Del Poeta Floyd L. Wormley Xiaorong Lin Host populations, challenges, and commercialization of cryptococcal vaccines PLoS Pathogens |
| title | Host populations, challenges, and commercialization of cryptococcal vaccines |
| title_full | Host populations, challenges, and commercialization of cryptococcal vaccines |
| title_fullStr | Host populations, challenges, and commercialization of cryptococcal vaccines |
| title_full_unstemmed | Host populations, challenges, and commercialization of cryptococcal vaccines |
| title_short | Host populations, challenges, and commercialization of cryptococcal vaccines |
| title_sort | host populations challenges and commercialization of cryptococcal vaccines |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910758/?tool=EBI |
| work_keys_str_mv | AT mauriziodelpoeta hostpopulationschallengesandcommercializationofcryptococcalvaccines AT floydlwormley hostpopulationschallengesandcommercializationofcryptococcalvaccines AT xiaoronglin hostpopulationschallengesandcommercializationofcryptococcalvaccines |