Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies
Data in this article presents the results of conventional cytogenetics and fluorescence in situ hybridization (FISH) analyses in 129 patients with confirmed MECOM rearrangement (https://doi.org/10.1016/j.cancergen.2019.03.002) [1]. Generally, the MECOM rearrangement has arisen through translocation,...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340919303786 |
| _version_ | 1828765658630848512 |
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| author | Zhenya Tang Guilin Tang Shimin Hu Keyur P. Patel C. Cameron Yin Wei Wang Pei Lin Gokce A. Toruner Chi Y. Ok Jun Gu Xinyan Lu Joseph D. Khoury L. Jeffrey Medeiros |
| author_facet | Zhenya Tang Guilin Tang Shimin Hu Keyur P. Patel C. Cameron Yin Wei Wang Pei Lin Gokce A. Toruner Chi Y. Ok Jun Gu Xinyan Lu Joseph D. Khoury L. Jeffrey Medeiros |
| author_sort | Zhenya Tang |
| collection | DOAJ |
| description | Data in this article presents the results of conventional cytogenetics and fluorescence in situ hybridization (FISH) analyses in 129 patients with confirmed MECOM rearrangement (https://doi.org/10.1016/j.cancergen.2019.03.002) [1]. Generally, the MECOM rearrangement has arisen through translocation, inversion, and insertion and/or unknown mechanism. In addition to the typical chromosomal aberrations, inv(3)(q21q26.2) and t(3; 3)(q21; q26.6) [2–4], over 50% of cases presented here exhibit a wide spectrum of MECOM rearrangement-driven, atypical chromosomal aberrations, including inv(3) with breakpoint other than 3q21; t(1; 3); t(2; 3); t(3; 6); t(3; 8); t(3; 12); t(3; 17); t(3; 21) as well as an insertion of 3q26.2 into different chromosomes. These cases are thoroughly characterized by karyotyping, interphase-, metaphase-, map-back FISH and whole chromosomal painting (WCP) analyses. Keywords: MECOM rearrangement, Inversion, Insertion, Translocation, Fluorescence in situ hybridization (FISH) |
| first_indexed | 2024-12-11T06:52:08Z |
| format | Article |
| id | doaj.art-e826ab350f4042df85dd53eaaff18dac |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T06:52:08Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-e826ab350f4042df85dd53eaaff18dac2022-12-22T01:16:53ZengElsevierData in Brief2352-34092019-06-0124Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignanciesZhenya Tang0Guilin Tang1Shimin Hu2Keyur P. Patel3C. Cameron Yin4Wei Wang5Pei Lin6Gokce A. Toruner7Chi Y. Ok8Jun Gu9Xinyan Lu10Joseph D. Khoury11L. Jeffrey Medeiros12Department of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Corresponding author.Department of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USACytogenetic Technology Program, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, School of Health Professions, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAData in this article presents the results of conventional cytogenetics and fluorescence in situ hybridization (FISH) analyses in 129 patients with confirmed MECOM rearrangement (https://doi.org/10.1016/j.cancergen.2019.03.002) [1]. Generally, the MECOM rearrangement has arisen through translocation, inversion, and insertion and/or unknown mechanism. In addition to the typical chromosomal aberrations, inv(3)(q21q26.2) and t(3; 3)(q21; q26.6) [2–4], over 50% of cases presented here exhibit a wide spectrum of MECOM rearrangement-driven, atypical chromosomal aberrations, including inv(3) with breakpoint other than 3q21; t(1; 3); t(2; 3); t(3; 6); t(3; 8); t(3; 12); t(3; 17); t(3; 21) as well as an insertion of 3q26.2 into different chromosomes. These cases are thoroughly characterized by karyotyping, interphase-, metaphase-, map-back FISH and whole chromosomal painting (WCP) analyses. Keywords: MECOM rearrangement, Inversion, Insertion, Translocation, Fluorescence in situ hybridization (FISH)http://www.sciencedirect.com/science/article/pii/S2352340919303786 |
| spellingShingle | Zhenya Tang Guilin Tang Shimin Hu Keyur P. Patel C. Cameron Yin Wei Wang Pei Lin Gokce A. Toruner Chi Y. Ok Jun Gu Xinyan Lu Joseph D. Khoury L. Jeffrey Medeiros Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies Data in Brief |
| title | Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies |
| title_full | Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies |
| title_fullStr | Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies |
| title_full_unstemmed | Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies |
| title_short | Data on MECOM rearrangement-driven chromosomal aberrations in myeloid malignancies |
| title_sort | data on mecom rearrangement driven chromosomal aberrations in myeloid malignancies |
| url | http://www.sciencedirect.com/science/article/pii/S2352340919303786 |
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