The Rhei radix rhizoma-based carbon dots ameliorates dextran sodium sulphate-induced ulcerative colitis in mice
AbstractAs an autoimmune disease of the colon, the incidence of ulcerative colitis (UC) remains high. Carbon dots (CDs), a new type of nanomaterials, display excellent biological activity and are expected to inspire a new treatment for UC. A green method was used to carbonise rhei radix rhizoma (RRR...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2023-12-01
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Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2023.2197947 |
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author | Yifan Zhang Jie Zhao Yusheng Zhao Xue Bai Yumin Chen Yuhan Liu Yue Zhang Hui Kong Huihua Qu Yan Zhao |
author_facet | Yifan Zhang Jie Zhao Yusheng Zhao Xue Bai Yumin Chen Yuhan Liu Yue Zhang Hui Kong Huihua Qu Yan Zhao |
author_sort | Yifan Zhang |
collection | DOAJ |
description | AbstractAs an autoimmune disease of the colon, the incidence of ulcerative colitis (UC) remains high. Carbon dots (CDs), a new type of nanomaterials, display excellent biological activity and are expected to inspire a new treatment for UC. A green method was used to carbonise rhei radix rhizoma (RRR) and extract CDs to study their anti-ulcer activity. The RRR-based carbon dots (RRR-CDs) were characterised by electron microscopy, optical techniques, and other techniques. The results indicated RRR-CDs have abundant chemical groups, excellent solubility and tiny size (1.374 nm–4.533 nm), which may be conducive to the exertion of inherent activity. Using a classic dextran sodium sulphate (DSS)-induced UC mouse model, for the first time, it was demonstrated RRR-CDs have significant anti-ulcerative activity in improving DAI score (from 2.8 to 1.6), colon length (4.15 to 6.08), and histopathology in mice. The underlying mechanisms of anti-ulcerative activity may be related to haemostatic, antioxidant, and anti-inflammatory activities to protect the mucosal barrier. RRR-CDs have symptomatic and potential mechanisms of treatment and are expected to become a candidate drug for the treatment of UC. This not only further expands the basis for the biological activity of CDs, but provides a potential treatment plan for solving thorny diseases in clinical practice. |
first_indexed | 2024-03-11T11:17:58Z |
format | Article |
id | doaj.art-e8277b6ccdbb40d8866a506240be7a28 |
institution | Directory Open Access Journal |
issn | 2169-1401 2169-141X |
language | English |
last_indexed | 2024-03-11T11:17:58Z |
publishDate | 2023-12-01 |
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series | Artificial Cells, Nanomedicine, and Biotechnology |
spelling | doaj.art-e8277b6ccdbb40d8866a506240be7a282023-11-10T17:19:32ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2023-12-0151118019110.1080/21691401.2023.2197947The Rhei radix rhizoma-based carbon dots ameliorates dextran sodium sulphate-induced ulcerative colitis in miceYifan Zhang0Jie Zhao1Yusheng Zhao2Xue Bai3Yumin Chen4Yuhan Liu5Yue Zhang6Hui Kong7Huihua Qu8Yan Zhao9School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCenter of Scientific Experiment, Beijing University of Chinese Medicine, Chaoyang District, Beijing, People’s Republic of ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaAbstractAs an autoimmune disease of the colon, the incidence of ulcerative colitis (UC) remains high. Carbon dots (CDs), a new type of nanomaterials, display excellent biological activity and are expected to inspire a new treatment for UC. A green method was used to carbonise rhei radix rhizoma (RRR) and extract CDs to study their anti-ulcer activity. The RRR-based carbon dots (RRR-CDs) were characterised by electron microscopy, optical techniques, and other techniques. The results indicated RRR-CDs have abundant chemical groups, excellent solubility and tiny size (1.374 nm–4.533 nm), which may be conducive to the exertion of inherent activity. Using a classic dextran sodium sulphate (DSS)-induced UC mouse model, for the first time, it was demonstrated RRR-CDs have significant anti-ulcerative activity in improving DAI score (from 2.8 to 1.6), colon length (4.15 to 6.08), and histopathology in mice. The underlying mechanisms of anti-ulcerative activity may be related to haemostatic, antioxidant, and anti-inflammatory activities to protect the mucosal barrier. RRR-CDs have symptomatic and potential mechanisms of treatment and are expected to become a candidate drug for the treatment of UC. This not only further expands the basis for the biological activity of CDs, but provides a potential treatment plan for solving thorny diseases in clinical practice.https://www.tandfonline.com/doi/10.1080/21691401.2023.2197947Anti-inflammatoryantioxidantcarbon dotsmucosal barrierRhei radix et rhizomaulcerative colitis |
spellingShingle | Yifan Zhang Jie Zhao Yusheng Zhao Xue Bai Yumin Chen Yuhan Liu Yue Zhang Hui Kong Huihua Qu Yan Zhao The Rhei radix rhizoma-based carbon dots ameliorates dextran sodium sulphate-induced ulcerative colitis in mice Artificial Cells, Nanomedicine, and Biotechnology Anti-inflammatory antioxidant carbon dots mucosal barrier Rhei radix et rhizoma ulcerative colitis |
title | The Rhei radix rhizoma-based carbon dots ameliorates dextran sodium sulphate-induced ulcerative colitis in mice |
title_full | The Rhei radix rhizoma-based carbon dots ameliorates dextran sodium sulphate-induced ulcerative colitis in mice |
title_fullStr | The Rhei radix rhizoma-based carbon dots ameliorates dextran sodium sulphate-induced ulcerative colitis in mice |
title_full_unstemmed | The Rhei radix rhizoma-based carbon dots ameliorates dextran sodium sulphate-induced ulcerative colitis in mice |
title_short | The Rhei radix rhizoma-based carbon dots ameliorates dextran sodium sulphate-induced ulcerative colitis in mice |
title_sort | rhei radix rhizoma based carbon dots ameliorates dextran sodium sulphate induced ulcerative colitis in mice |
topic | Anti-inflammatory antioxidant carbon dots mucosal barrier Rhei radix et rhizoma ulcerative colitis |
url | https://www.tandfonline.com/doi/10.1080/21691401.2023.2197947 |
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