Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents

Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents

Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6-<i>n-</i>propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-...

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Bibliographic Details
Main Authors: Samir M. Awad, Yasser M. Zohny, Sahar A. Ali, Shahenda Mahgoub, Ahmed M. Said
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
hyperthyroidism
thiouracil
pyrimidine
antithyroid
PTU
LPO
Online Access:https://www.mdpi.com/1420-3049/23/11/2913

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