The association between antibiotic use and outcomes of HCC patients treated with immune checkpoint inhibitors
ObjectiveRecently, immune checkpoint inhibitor (ICI) treatment has shown encouraging performance in improving the prognosis of hepatocellular carcinoma (HCC) patients. The gut microbiome plays a vital role in altering the efficacy of ICIs, which may be impacted by antibiotics. The aim of the meta-an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.956533/full |
| _version_ | 1811215025652629504 |
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| author | Lilong Zhang Lilong Zhang Chen Chen Dongqi Chai Dongqi Chai Chunlei Li Chunlei Li Yongjun Guan Yongjun Guan Li Liu Li Liu Tianrui Kuang Tianrui Kuang Wenhong Deng Weixing Wang |
| author_facet | Lilong Zhang Lilong Zhang Chen Chen Dongqi Chai Dongqi Chai Chunlei Li Chunlei Li Yongjun Guan Yongjun Guan Li Liu Li Liu Tianrui Kuang Tianrui Kuang Wenhong Deng Weixing Wang |
| author_sort | Lilong Zhang |
| collection | DOAJ |
| description | ObjectiveRecently, immune checkpoint inhibitor (ICI) treatment has shown encouraging performance in improving the prognosis of hepatocellular carcinoma (HCC) patients. The gut microbiome plays a vital role in altering the efficacy of ICIs, which may be impacted by antibiotics. The aim of the meta-analysis is to estimate the influence of antibiotic use on the survival of HCC patients treated with ICIs.MethodsThe literature review was conducted using databases like PubMed, EMBASE, Cochrane Library, CNKI, WANFANG DATA, VIP, Google Scholar, and ClinicalTrials.gov before May 15, 2022. The primary endpoints were overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR).ResultsA total of six retrospective studies met the inclusion criteria. 1056 patients were included in the study, of which 352 (33.33%) received antibiotic treatment. The meta-analysis results revealed antibiotic use did not affect the OS (HR: 1.41, 95% CI: 0.96-2.08, P = 0.088) and PFS (HR: 1.21, 95% CI: 0.73-2.00, P = 0.459) in HCC patients treated with ICIs. Besides, the use of antibiotics did not reduce the ORR (OR: 1.06, 95% CI: 0.69-1.64, P = 0.784) and DCR (OR: 0.42, 95% CI: 0.09-2.06, P = 0.286) in HCC patients treated with ICIs.ConclusionCurrent evidence reveals that antibiotic use does alter the therapeutic efficacy of ICIs in HCC patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/, identifier CRD42022311948. |
| first_indexed | 2024-04-12T06:14:21Z |
| format | Article |
| id | doaj.art-e82b4d50f4c4442c8c93dd4bbf08fe77 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T06:14:21Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e82b4d50f4c4442c8c93dd4bbf08fe772022-12-22T03:44:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.956533956533The association between antibiotic use and outcomes of HCC patients treated with immune checkpoint inhibitorsLilong Zhang0Lilong Zhang1Chen Chen2Dongqi Chai3Dongqi Chai4Chunlei Li5Chunlei Li6Yongjun Guan7Yongjun Guan8Li Liu9Li Liu10Tianrui Kuang11Tianrui Kuang12Wenhong Deng13Weixing Wang14Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaHubei Key Laboratory of Digestive System Disease, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaObjectiveRecently, immune checkpoint inhibitor (ICI) treatment has shown encouraging performance in improving the prognosis of hepatocellular carcinoma (HCC) patients. The gut microbiome plays a vital role in altering the efficacy of ICIs, which may be impacted by antibiotics. The aim of the meta-analysis is to estimate the influence of antibiotic use on the survival of HCC patients treated with ICIs.MethodsThe literature review was conducted using databases like PubMed, EMBASE, Cochrane Library, CNKI, WANFANG DATA, VIP, Google Scholar, and ClinicalTrials.gov before May 15, 2022. The primary endpoints were overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and disease control rate (DCR).ResultsA total of six retrospective studies met the inclusion criteria. 1056 patients were included in the study, of which 352 (33.33%) received antibiotic treatment. The meta-analysis results revealed antibiotic use did not affect the OS (HR: 1.41, 95% CI: 0.96-2.08, P = 0.088) and PFS (HR: 1.21, 95% CI: 0.73-2.00, P = 0.459) in HCC patients treated with ICIs. Besides, the use of antibiotics did not reduce the ORR (OR: 1.06, 95% CI: 0.69-1.64, P = 0.784) and DCR (OR: 0.42, 95% CI: 0.09-2.06, P = 0.286) in HCC patients treated with ICIs.ConclusionCurrent evidence reveals that antibiotic use does alter the therapeutic efficacy of ICIs in HCC patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/, identifier CRD42022311948.https://www.frontiersin.org/articles/10.3389/fimmu.2022.956533/fullimmune checkpoint inhibitorsantibiotichepatocellular carcinomaprognosismeta-analysis |
| spellingShingle | Lilong Zhang Lilong Zhang Chen Chen Dongqi Chai Dongqi Chai Chunlei Li Chunlei Li Yongjun Guan Yongjun Guan Li Liu Li Liu Tianrui Kuang Tianrui Kuang Wenhong Deng Weixing Wang The association between antibiotic use and outcomes of HCC patients treated with immune checkpoint inhibitors Frontiers in Immunology immune checkpoint inhibitors antibiotic hepatocellular carcinoma prognosis meta-analysis |
| title | The association between antibiotic use and outcomes of HCC patients treated with immune checkpoint inhibitors |
| title_full | The association between antibiotic use and outcomes of HCC patients treated with immune checkpoint inhibitors |
| title_fullStr | The association between antibiotic use and outcomes of HCC patients treated with immune checkpoint inhibitors |
| title_full_unstemmed | The association between antibiotic use and outcomes of HCC patients treated with immune checkpoint inhibitors |
| title_short | The association between antibiotic use and outcomes of HCC patients treated with immune checkpoint inhibitors |
| title_sort | association between antibiotic use and outcomes of hcc patients treated with immune checkpoint inhibitors |
| topic | immune checkpoint inhibitors antibiotic hepatocellular carcinoma prognosis meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.956533/full |
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