Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency
A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding sulfadiazines 2–18 and hydrozaones 19a–h which were...
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2020-03-01
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| Series: | Acta Chimica Slovenica |
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| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/5308 |
| _version_ | 1818446505976004608 |
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| author | Sherihan El-Hadidy Sraa Abu-Melha |
| author_facet | Sherihan El-Hadidy Sraa Abu-Melha |
| author_sort | Sherihan El-Hadidy |
| collection | DOAJ |
| description | A set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding sulfadiazines 2–18 and hydrozaones 19a–h which were evaluated for their in vitro cytotoxicity versus four cancer cell lines. Compounds 3, 5, 19d and 19h were active against the tested cancer cells. |
| first_indexed | 2024-12-14T19:48:48Z |
| format | Article |
| id | doaj.art-e82cd82034bf4ce8a782923b3d695f99 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-14T19:48:48Z |
| publishDate | 2020-03-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-e82cd82034bf4ce8a782923b3d695f992022-12-21T22:49:29ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552020-03-0167116717810.17344/acsi.2019.5308770Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical PotencySherihan El-Hadidy0Sraa Abu-Melha1Department of Engineering Chemistry, Canal High Institute of Engineering and Technology, Sues, EgyptbDepartment of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi ArabiaA set of substituted sulfadiazine compounds was prepared as cytotoxic and antitumor agents by using 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide (1) as the starting material. Compound 1 was reacted with different reagents to give the corresponding sulfadiazines 2–18 and hydrozaones 19a–h which were evaluated for their in vitro cytotoxicity versus four cancer cell lines. Compounds 3, 5, 19d and 19h were active against the tested cancer cells.https://journals.matheo.si/index.php/ACSi/article/view/5308anticancersulfonamideoxadiazolepyridinethiazole |
| spellingShingle | Sherihan El-Hadidy Sraa Abu-Melha Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency Acta Chimica Slovenica anticancer sulfonamide oxadiazole pyridine thiazole |
| title | Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency |
| title_full | Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency |
| title_fullStr | Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency |
| title_full_unstemmed | Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency |
| title_short | Some Studies in Sulfadiazine Incorporating Pyridine, Pyrimidine, Oxadiazole, and Azo Moieties Endowed with Pharmaceutical Potency |
| title_sort | some studies in sulfadiazine incorporating pyridine pyrimidine oxadiazole and azo moieties endowed with pharmaceutical potency |
| topic | anticancer sulfonamide oxadiazole pyridine thiazole |
| url | https://journals.matheo.si/index.php/ACSi/article/view/5308 |
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