Stepwise Relationship Between Components of Metabolic Syndrome and Risk of Colorectal Adenoma in a Taiwanese Population Receiving Screening Colonoscopy
Metabolic syndrome (MS) is a cluster of diseases related to insulin resistance and is an important cardiovascular risk factor. In addition, MS has been linked to some malignancies, including colorectal cancer. Colon adenoma is a well-established pre-malignant lesion of colorectal cancer. The aim of...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-02-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664611600168 |
| _version_ | 1811233616997384192 |
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| author | Nien-Chih Hu Jong-Dar Chen Yu-Min Lin Jun-Yih Chang Yu-Hung Chen |
| author_facet | Nien-Chih Hu Jong-Dar Chen Yu-Min Lin Jun-Yih Chang Yu-Hung Chen |
| author_sort | Nien-Chih Hu |
| collection | DOAJ |
| description | Metabolic syndrome (MS) is a cluster of diseases related to insulin resistance and is an important cardiovascular risk factor. In addition, MS has been linked to some malignancies, including colorectal cancer. Colon adenoma is a well-established pre-malignant lesion of colorectal cancer. The aim of this study was to determine the effect of various components of MS on the risk of colorectal adenoma.
Methods: From October 2004 to April 2006, 3106 subjects who had undergone complete colonoscopy for health examinations at the hospital were enrolled. MS was defined according to the modified National Cholesterol Education Program Adult Treatment Panel III definition for South Asians and Chinese. Multivariate logistic regression was used to analyze the association between components of MS and colorectal adenoma.
Results: Of the 3106 subjects, the mean age was 47.1 ± 10.8 years and there were 397 (13%) subjects with pathologically proven colorectal adenoma. Male sex, old age (=50 years), current smokers, and abdominal obesity were associated with increasing risk of colorectal adenoma. MS was associated with increased risk of colorectal adenoma (odds ratio: 1.71, 95% confidence interval: 1.34-2.71), and this risk increased with the number of metabolic components. Multiple and synchronous adenomas of the proximal and distal colon were positively associated with MS.
Conclusion: Subjects with metabolic syndrome have increased risk of developing colorectal adenoma. Screening colonoscopy for prevention of colorectal adenoma might be warranted when abdominal obesity or more than three components of MS are present. |
| first_indexed | 2024-04-12T11:22:42Z |
| format | Article |
| id | doaj.art-e82da99c387e46fa8a037f885cfa0d52 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-12T11:22:42Z |
| publishDate | 2011-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-e82da99c387e46fa8a037f885cfa0d522022-12-22T03:35:18ZengElsevierJournal of the Formosan Medical Association0929-66462011-02-01110210010810.1016/S0929-6646(11)60016-8Stepwise Relationship Between Components of Metabolic Syndrome and Risk of Colorectal Adenoma in a Taiwanese Population Receiving Screening ColonoscopyNien-Chih Hu0Jong-Dar Chen1Yu-Min Lin2Jun-Yih Chang3Yu-Hung Chen4Department of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwanDepartment of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwanDepartment of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwanDepartment of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, TaiwanMetabolic syndrome (MS) is a cluster of diseases related to insulin resistance and is an important cardiovascular risk factor. In addition, MS has been linked to some malignancies, including colorectal cancer. Colon adenoma is a well-established pre-malignant lesion of colorectal cancer. The aim of this study was to determine the effect of various components of MS on the risk of colorectal adenoma. Methods: From October 2004 to April 2006, 3106 subjects who had undergone complete colonoscopy for health examinations at the hospital were enrolled. MS was defined according to the modified National Cholesterol Education Program Adult Treatment Panel III definition for South Asians and Chinese. Multivariate logistic regression was used to analyze the association between components of MS and colorectal adenoma. Results: Of the 3106 subjects, the mean age was 47.1 ± 10.8 years and there were 397 (13%) subjects with pathologically proven colorectal adenoma. Male sex, old age (=50 years), current smokers, and abdominal obesity were associated with increasing risk of colorectal adenoma. MS was associated with increased risk of colorectal adenoma (odds ratio: 1.71, 95% confidence interval: 1.34-2.71), and this risk increased with the number of metabolic components. Multiple and synchronous adenomas of the proximal and distal colon were positively associated with MS. Conclusion: Subjects with metabolic syndrome have increased risk of developing colorectal adenoma. Screening colonoscopy for prevention of colorectal adenoma might be warranted when abdominal obesity or more than three components of MS are present.http://www.sciencedirect.com/science/article/pii/S0929664611600168abdominal obesitycolorectal adenomametabolic syndrome |
| spellingShingle | Nien-Chih Hu Jong-Dar Chen Yu-Min Lin Jun-Yih Chang Yu-Hung Chen Stepwise Relationship Between Components of Metabolic Syndrome and Risk of Colorectal Adenoma in a Taiwanese Population Receiving Screening Colonoscopy Journal of the Formosan Medical Association abdominal obesity colorectal adenoma metabolic syndrome |
| title | Stepwise Relationship Between Components of Metabolic Syndrome and Risk of Colorectal Adenoma in a Taiwanese Population Receiving Screening Colonoscopy |
| title_full | Stepwise Relationship Between Components of Metabolic Syndrome and Risk of Colorectal Adenoma in a Taiwanese Population Receiving Screening Colonoscopy |
| title_fullStr | Stepwise Relationship Between Components of Metabolic Syndrome and Risk of Colorectal Adenoma in a Taiwanese Population Receiving Screening Colonoscopy |
| title_full_unstemmed | Stepwise Relationship Between Components of Metabolic Syndrome and Risk of Colorectal Adenoma in a Taiwanese Population Receiving Screening Colonoscopy |
| title_short | Stepwise Relationship Between Components of Metabolic Syndrome and Risk of Colorectal Adenoma in a Taiwanese Population Receiving Screening Colonoscopy |
| title_sort | stepwise relationship between components of metabolic syndrome and risk of colorectal adenoma in a taiwanese population receiving screening colonoscopy |
| topic | abdominal obesity colorectal adenoma metabolic syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S0929664611600168 |
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