Recent Progress on Vaccines Produced in Transgenic Plants
The development of vaccines from plants has been going on for over two decades now. Vaccine production in plants requires time and a lot of effort. Despite global efforts in plant-made vaccine development, there are still challenges that hinder the realization of the final objective of manufacturing...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/11/1861 |
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| author | Goabaone Gaobotse Srividhya Venkataraman Kamogelo M. Mmereke Khaled Moustafa Kathleen Hefferon Abdullah Makhzoum |
| author_facet | Goabaone Gaobotse Srividhya Venkataraman Kamogelo M. Mmereke Khaled Moustafa Kathleen Hefferon Abdullah Makhzoum |
| author_sort | Goabaone Gaobotse |
| collection | DOAJ |
| description | The development of vaccines from plants has been going on for over two decades now. Vaccine production in plants requires time and a lot of effort. Despite global efforts in plant-made vaccine development, there are still challenges that hinder the realization of the final objective of manufacturing approved and safe products. Despite delays in the commercialization of plant-made vaccines, there are some human vaccines that are in clinical trials. The novel coronavirus (SARS-CoV-2) and its resultant disease, coronavirus disease 2019 (COVID-19), have reminded the global scientific community of the importance of vaccines. Plant-made vaccines could not be more important in tackling such unexpected pandemics as COVID-19. In this review, we explore current progress in the development of vaccines manufactured in transgenic plants for different human diseases over the past 5 years. However, we first explore the different host species and plant expression systems during recombinant protein production, including their shortcomings and benefits. Lastly, we address the optimization of existing plant-dependent vaccine production protocols that are aimed at improving the recovery and purification of these recombinant proteins. |
| first_indexed | 2024-03-09T18:34:46Z |
| format | Article |
| id | doaj.art-e82e4f9fe9e04b28ad187e41ed847e0b |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T18:34:46Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-e82e4f9fe9e04b28ad187e41ed847e0b2023-11-24T07:13:52ZengMDPI AGVaccines2076-393X2022-11-011011186110.3390/vaccines10111861Recent Progress on Vaccines Produced in Transgenic PlantsGoabaone Gaobotse0Srividhya Venkataraman1Kamogelo M. Mmereke2Khaled Moustafa3Kathleen Hefferon4Abdullah Makhzoum5Department of Biological Sciences & Biotechnology, Botswana International University of Science & Technology, Palapye, BotswanaVirology Laboratory, Department of Cell & Systems Biology, University of Toronto, Toronto, ON M5S 3B2, CanadaDepartment of Biological Sciences & Biotechnology, Botswana International University of Science & Technology, Palapye, BotswanaThe Arabic Preprint Server/Arabic Science Archive (ArabiXiv)Department of Microbiology, Cornell University, Ithaca, NY 14850, USADepartment of Biological Sciences & Biotechnology, Botswana International University of Science & Technology, Palapye, BotswanaThe development of vaccines from plants has been going on for over two decades now. Vaccine production in plants requires time and a lot of effort. Despite global efforts in plant-made vaccine development, there are still challenges that hinder the realization of the final objective of manufacturing approved and safe products. Despite delays in the commercialization of plant-made vaccines, there are some human vaccines that are in clinical trials. The novel coronavirus (SARS-CoV-2) and its resultant disease, coronavirus disease 2019 (COVID-19), have reminded the global scientific community of the importance of vaccines. Plant-made vaccines could not be more important in tackling such unexpected pandemics as COVID-19. In this review, we explore current progress in the development of vaccines manufactured in transgenic plants for different human diseases over the past 5 years. However, we first explore the different host species and plant expression systems during recombinant protein production, including their shortcomings and benefits. Lastly, we address the optimization of existing plant-dependent vaccine production protocols that are aimed at improving the recovery and purification of these recombinant proteins.https://www.mdpi.com/2076-393X/10/11/1861vaccinetransgenic plantplant-made vaccineplant molecular pharmingrecombinant proteinexpression |
| spellingShingle | Goabaone Gaobotse Srividhya Venkataraman Kamogelo M. Mmereke Khaled Moustafa Kathleen Hefferon Abdullah Makhzoum Recent Progress on Vaccines Produced in Transgenic Plants Vaccines vaccine transgenic plant plant-made vaccine plant molecular pharming recombinant protein expression |
| title | Recent Progress on Vaccines Produced in Transgenic Plants |
| title_full | Recent Progress on Vaccines Produced in Transgenic Plants |
| title_fullStr | Recent Progress on Vaccines Produced in Transgenic Plants |
| title_full_unstemmed | Recent Progress on Vaccines Produced in Transgenic Plants |
| title_short | Recent Progress on Vaccines Produced in Transgenic Plants |
| title_sort | recent progress on vaccines produced in transgenic plants |
| topic | vaccine transgenic plant plant-made vaccine plant molecular pharming recombinant protein expression |
| url | https://www.mdpi.com/2076-393X/10/11/1861 |
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