Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in Rats
Background: Gum arabic (GA) contains anti-oxidant and anti-inflammatory compounds and protects tissues. Objectives: The purpose of the present study was to investigate the protective effect of GA on the spinal cord’s motor neurons after ischemia-reperfusion (I-R) injury. Materials & Methods: Thi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Guilan University of Medical Sciences
2024-01-01
|
| Series: | Caspian Journal of Neurological Sciences |
| Subjects: | |
| Online Access: | http://cjns.gums.ac.ir/article-1-690-en.pdf |
| _version_ | 1827366525884956672 |
|---|---|
| author | Hesam Yahak Gholam Hossein Farjah Bagher Pourheydar Mojtaba Karimipour |
| author_facet | Hesam Yahak Gholam Hossein Farjah Bagher Pourheydar Mojtaba Karimipour |
| author_sort | Hesam Yahak |
| collection | DOAJ |
| description | Background: Gum arabic (GA) contains anti-oxidant and anti-inflammatory compounds and protects tissues.
Objectives: The purpose of the present study was to investigate the protective effect of GA on the spinal cord’s motor neurons after ischemia-reperfusion (I-R) injury.
Materials & Methods: Thirty-five male rats (Sprague-Dawley) were randomly divided into five groups: Intact, sham surgery, control (4 mL/kg distilled water+I/R), low-dose gum arabic (GA 1 g/kg+I-R), and high-dose gum arabic (GA 4 g/kg+I-R). In the experimental groups, oral gavages’ treatment was performed for 21 days before surgery. Three days after I-R, the rats were evaluated for neurological function, biochemical, and histological analysis.
Results: The mean motor deficit index (MDI) in the GA groups versus the control group was significantly lower (P<0.01). About 72 hours after I-R, the mean plasma level of superoxide dismutase and total anti-oxidant capacity in the GA 4 g/kg group were higher than the control group (P<0.05). However, there was no significant difference in the plasma level of catalase between the GA 4 g/kg and the control groups (P<0.05). Approximately 67% of the motor neurons were destroyed in the control group, while this ratio was about 18% in the GA 4 g/kg group.
Conclusion: This study showed that GA (4 g/kg) protects the motor neurons of the spinal cord against ischemia-reperfusion injury. |
| first_indexed | 2024-03-08T08:51:47Z |
| format | Article |
| id | doaj.art-e82f4aed7bf0412b973b3dcf42dfbde1 |
| institution | Directory Open Access Journal |
| issn | 2423-4818 |
| language | English |
| last_indexed | 2024-03-08T08:51:47Z |
| publishDate | 2024-01-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj.art-e82f4aed7bf0412b973b3dcf42dfbde12024-02-01T09:27:49ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2423-48182024-01-011014756Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in RatsHesam Yahak0Gholam Hossein Farjah1Bagher Pourheydar2Mojtaba Karimipour3 Neurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran. Neurophysiology Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran. Department of Anatomical Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Department of Anatomical Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Background: Gum arabic (GA) contains anti-oxidant and anti-inflammatory compounds and protects tissues. Objectives: The purpose of the present study was to investigate the protective effect of GA on the spinal cord’s motor neurons after ischemia-reperfusion (I-R) injury. Materials & Methods: Thirty-five male rats (Sprague-Dawley) were randomly divided into five groups: Intact, sham surgery, control (4 mL/kg distilled water+I/R), low-dose gum arabic (GA 1 g/kg+I-R), and high-dose gum arabic (GA 4 g/kg+I-R). In the experimental groups, oral gavages’ treatment was performed for 21 days before surgery. Three days after I-R, the rats were evaluated for neurological function, biochemical, and histological analysis. Results: The mean motor deficit index (MDI) in the GA groups versus the control group was significantly lower (P<0.01). About 72 hours after I-R, the mean plasma level of superoxide dismutase and total anti-oxidant capacity in the GA 4 g/kg group were higher than the control group (P<0.05). However, there was no significant difference in the plasma level of catalase between the GA 4 g/kg and the control groups (P<0.05). Approximately 67% of the motor neurons were destroyed in the control group, while this ratio was about 18% in the GA 4 g/kg group. Conclusion: This study showed that GA (4 g/kg) protects the motor neurons of the spinal cord against ischemia-reperfusion injury.http://cjns.gums.ac.ir/article-1-690-en.pdfgum arabicischemiareperfusionspinal cordrats |
| spellingShingle | Hesam Yahak Gholam Hossein Farjah Bagher Pourheydar Mojtaba Karimipour Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in Rats Caspian Journal of Neurological Sciences gum arabic ischemia reperfusion spinal cord rats |
| title | Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in Rats |
| title_full | Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in Rats |
| title_fullStr | Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in Rats |
| title_full_unstemmed | Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in Rats |
| title_short | Protective Effect of Gum Arabic on Spinal Cord Ischemia-reperfusion Injury in Rats |
| title_sort | protective effect of gum arabic on spinal cord ischemia reperfusion injury in rats |
| topic | gum arabic ischemia reperfusion spinal cord rats |
| url | http://cjns.gums.ac.ir/article-1-690-en.pdf |
| work_keys_str_mv | AT hesamyahak protectiveeffectofgumarabiconspinalcordischemiareperfusioninjuryinrats AT gholamhosseinfarjah protectiveeffectofgumarabiconspinalcordischemiareperfusioninjuryinrats AT bagherpourheydar protectiveeffectofgumarabiconspinalcordischemiareperfusioninjuryinrats AT mojtabakarimipour protectiveeffectofgumarabiconspinalcordischemiareperfusioninjuryinrats |