Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure

Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure

Abstract The excitatory/inhibitory (E/I) imbalance hypothesis posits that imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral characteristics of autism. However, how E/I imbalance arises and how it may differ across autism symptomatology and br...

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Bibliographic Details
Main Authors:	Viola Hollestein, Geert Poelmans, Natalie J. Forde, Christian F. Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell’Acqua, Declan G. M. Murphy, Nicolaas A. Puts, Julian Tillmann, Tony Charman, Emily J. H. Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K. Buitelaar, Jilly Naaijen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-01-01
Series:	Translational Psychiatry
Online Access:	https://doi.org/10.1038/s41398-023-02317-5

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