Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism

Evidence for a Cyanine Link Between Propargylamine Drugs and Monoamine Oxidase Clarifies the Inactivation Mechanism

Successful propargylamine drugs such as deprenyl inactivate monoamine oxidase (MAO), a target in multi-faceted approaches to prevent neurodegeneration in the aging population, but the chemical structure and mechanism of the irreversible inhibition are still debated. We characterized the covalent cya...

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Bibliographic Details
Main Authors: Alen Albreht, Irena Vovk, Janez Mavri, Jose Marco-Contelles, Rona R. Ramsay
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Chemistry
Subjects:
monoamine oxidase
propargylamine
inhibition mechanism
structure
electrostatic interactions
quantum chemical calculations
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00169/full

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