MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathways
Summary: Mitochondria are key organelles inside the cell that house a wide range of molecular pathways involved in energy metabolism, ions homeostasis, and cell death. Several databases characterize the different mitochondrial aspects and thus support basic and clinical research.Here we present Mito...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221002923 |
| _version_ | 1818647190879338496 |
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| author | Saverio Marchi Marco Zanella Paolo Pinton Silvia Crafa Giovanni Boniolo |
| author_facet | Saverio Marchi Marco Zanella Paolo Pinton Silvia Crafa Giovanni Boniolo |
| author_sort | Saverio Marchi |
| collection | DOAJ |
| description | Summary: Mitochondria are key organelles inside the cell that house a wide range of molecular pathways involved in energy metabolism, ions homeostasis, and cell death. Several databases characterize the different mitochondrial aspects and thus support basic and clinical research.Here we present MitopatHs, a web-based data set that allows navigating among the biochemical signaling pathways (PatHs) of human (H) mitochondria (Mito). MitopatHs is designed to visualize and comprehend virtually all types of pathways in two complementary ways: a logical view, where the sequence of biochemical reactions is presented as logical deductions, and an intuitive graphical visualization, which enables the examination and the analysis of each step of the pathway. MitopatHs is a manually curated, open access and collaborative tool, whose goal is to enable the visualization and comprehension of complicated molecular routes in an easy and fast way. |
| first_indexed | 2024-12-17T00:58:36Z |
| format | Article |
| id | doaj.art-e830813a5d924aceb0a70c5e203bde58 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-17T00:58:36Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-e830813a5d924aceb0a70c5e203bde582022-12-21T22:09:33ZengElsevieriScience2589-00422021-04-01244102324MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathwaysSaverio Marchi0Marco Zanella1Paolo Pinton2Silvia Crafa3Giovanni Boniolo4Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy; Corresponding authorDepartment of Mathematics, University of Padua, Padua, ItalyDepartment of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Ravenna, ItalyDepartment of Mathematics, University of Padua, Padua, Italy; Corresponding authorDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, ItalySummary: Mitochondria are key organelles inside the cell that house a wide range of molecular pathways involved in energy metabolism, ions homeostasis, and cell death. Several databases characterize the different mitochondrial aspects and thus support basic and clinical research.Here we present MitopatHs, a web-based data set that allows navigating among the biochemical signaling pathways (PatHs) of human (H) mitochondria (Mito). MitopatHs is designed to visualize and comprehend virtually all types of pathways in two complementary ways: a logical view, where the sequence of biochemical reactions is presented as logical deductions, and an intuitive graphical visualization, which enables the examination and the analysis of each step of the pathway. MitopatHs is a manually curated, open access and collaborative tool, whose goal is to enable the visualization and comprehension of complicated molecular routes in an easy and fast way.http://www.sciencedirect.com/science/article/pii/S2589004221002923Cell BiologyMolecular NetworkSoftware |
| spellingShingle | Saverio Marchi Marco Zanella Paolo Pinton Silvia Crafa Giovanni Boniolo MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathways iScience Cell Biology Molecular Network Software |
| title | MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathways |
| title_full | MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathways |
| title_fullStr | MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathways |
| title_full_unstemmed | MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathways |
| title_short | MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathways |
| title_sort | mitopaths a new logically framed tool for visualizing multiple mitochondrial pathways |
| topic | Cell Biology Molecular Network Software |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221002923 |
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