Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies
Objective: Obesity is associated with increased thyroid-stimulating hormone (TSH) in non-pregnant subjects, but this phenomenon has not been fully characterized during pregnancy. Our aim was to evaluate the impact of BMI on first-trimester TSH in a wide cohort of pregnant women with negative anti-th...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2024-04-01
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| Series: | European Thyroid Journal |
| Subjects: | |
| Online Access: | https://etj.bioscientifica.com/view/journals/etj/aop/etj-23-0213/etj-23-0213.xml |
| _version_ | 1797201697182842880 |
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| author | Laura Croce Fausta Beneventi Federica Ripepi Irene De Maggio Alberto Malovini Camilla Bellingeri Francesca Coperchini Marsida Teliti Mario Rotondi Arsenio Spinillo Flavia Magri |
| author_facet | Laura Croce Fausta Beneventi Federica Ripepi Irene De Maggio Alberto Malovini Camilla Bellingeri Francesca Coperchini Marsida Teliti Mario Rotondi Arsenio Spinillo Flavia Magri |
| author_sort | Laura Croce |
| collection | DOAJ |
| description | Objective: Obesity is associated with increased thyroid-stimulating hormone (TSH) in non-pregnant subjects, but this phenomenon has not been fully characterized during pregnancy. Our aim was to evaluate the impact of BMI on first-trimester TSH in a wide cohort of pregnant women with negative anti-thyroperoxidase antibodies (AbTPO) and its implications on uterine artery pulsatility index (UtA-PI), a marker of early placentation.
Methods: The study included 2268 AbTPO-negative pregnant women at their first antenatal visit. Anamnestic data, BMI, TSH, anti-nuclear antibody (ANA) and extractable nuclear antigen (ENA) positivity and mean UtA-PI were collected.
Results: A total of 1693 women had normal weight, 435 were overweight and 140 were obese. Maternal age, ANA/ENA positivity, history of autoimmune diseases and familiar history of thyroid diseases were similar in the three groups. TSH was significantly higher in obese women (1.8 (IQR: 1.4–2.4) mU/L) when compared to normal weight (1.6 (IQR: 1.2–2.2) mU/L) and overweight (median: 1.6 (IQR: 1.2–2.2) mU/L) ones (P < 0.001). BMI was significantly related with the risk of having a TSH level ≥4 mU/L at logistic regression, independently from non-thyroid autoimmunity, smoking or familiar predisposition for thyroid diseases (OR: 1.125, 95% CI: 1.080–1.172, P < 0.001). A restricted cubic splines regression showed a non-linear relationship between BMI and TSH. Women with a TSH ≥4 mU/L had a higher UtA-PI, independently from BMI.
Conclusion: Overweight/obesity is significantly related with TSH serum levels in AbTPO-negative pregnant women, independently from the other risk factors for hypothyroidism during pregnancy. The increase of TSH levels could be clinically relevant, as suggested by its association with abnormal UtA-PI, a surrogate marker of abnormal placentation. |
| first_indexed | 2024-04-24T07:51:39Z |
| format | Article |
| id | doaj.art-e832efc4231841849e5ce603c10865ab |
| institution | Directory Open Access Journal |
| issn | 2235-0802 |
| language | English |
| last_indexed | 2024-04-24T07:51:39Z |
| publishDate | 2024-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj.art-e832efc4231841849e5ce603c10865ab2024-04-18T11:17:46ZengBioscientificaEuropean Thyroid Journal2235-08022024-04-01132110https://doi.org/10.1530/ETJ-23-0213Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodiesLaura Croce0Fausta Beneventi1Federica Ripepi2Irene De Maggio3Alberto Malovini4Camilla Bellingeri5Francesca Coperchini6Marsida Teliti7Mario Rotondi8Arsenio Spinillo9Flavia Magri10Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy; Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), ItalyDepartment of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), ItalyIstituti Clinici Scientifici Maugeri IRCCS, Laboratory of Informatics and Systems Engineering for Clinical Research, Pavia (PV), ItalyDepartment of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy; Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy Department of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy; Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia (PV), ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia (PV), Italy; Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia (PV), Italy Objective: Obesity is associated with increased thyroid-stimulating hormone (TSH) in non-pregnant subjects, but this phenomenon has not been fully characterized during pregnancy. Our aim was to evaluate the impact of BMI on first-trimester TSH in a wide cohort of pregnant women with negative anti-thyroperoxidase antibodies (AbTPO) and its implications on uterine artery pulsatility index (UtA-PI), a marker of early placentation. Methods: The study included 2268 AbTPO-negative pregnant women at their first antenatal visit. Anamnestic data, BMI, TSH, anti-nuclear antibody (ANA) and extractable nuclear antigen (ENA) positivity and mean UtA-PI were collected. Results: A total of 1693 women had normal weight, 435 were overweight and 140 were obese. Maternal age, ANA/ENA positivity, history of autoimmune diseases and familiar history of thyroid diseases were similar in the three groups. TSH was significantly higher in obese women (1.8 (IQR: 1.4–2.4) mU/L) when compared to normal weight (1.6 (IQR: 1.2–2.2) mU/L) and overweight (median: 1.6 (IQR: 1.2–2.2) mU/L) ones (P < 0.001). BMI was significantly related with the risk of having a TSH level ≥4 mU/L at logistic regression, independently from non-thyroid autoimmunity, smoking or familiar predisposition for thyroid diseases (OR: 1.125, 95% CI: 1.080–1.172, P < 0.001). A restricted cubic splines regression showed a non-linear relationship between BMI and TSH. Women with a TSH ≥4 mU/L had a higher UtA-PI, independently from BMI. Conclusion: Overweight/obesity is significantly related with TSH serum levels in AbTPO-negative pregnant women, independently from the other risk factors for hypothyroidism during pregnancy. The increase of TSH levels could be clinically relevant, as suggested by its association with abnormal UtA-PI, a surrogate marker of abnormal placentation.https://etj.bioscientifica.com/view/journals/etj/aop/etj-23-0213/etj-23-0213.xmlthyroidpregnancyobesitytshhypothyroidism |
| spellingShingle | Laura Croce Fausta Beneventi Federica Ripepi Irene De Maggio Alberto Malovini Camilla Bellingeri Francesca Coperchini Marsida Teliti Mario Rotondi Arsenio Spinillo Flavia Magri Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies European Thyroid Journal thyroid pregnancy obesity tsh hypothyroidism |
| title | Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies |
| title_full | Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies |
| title_fullStr | Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies |
| title_full_unstemmed | Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies |
| title_short | Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies |
| title_sort | relationship between maternal obesity and first trimester tsh in women with negative anti tpo antibodies |
| topic | thyroid pregnancy obesity tsh hypothyroidism |
| url | https://etj.bioscientifica.com/view/journals/etj/aop/etj-23-0213/etj-23-0213.xml |
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