Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory
Background and Aim: Working memory is a dynamic neural system for temporarily maintaining and processing of information. Prefrontal cortex (PFC) is the main processing center of Working memory by using different neurotransmitter systems communicate with other brain structures such as Basolateral Amy...
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| Format: | Article |
| Language: | fas |
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Arak Medical University
2019-04-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://jams.arakmu.ac.ir/article-1-5858-en.html |
| _version_ | 1818689423401811968 |
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| author | Maryam Rahimi Tesiye Farhad Valizadegan Shahrbanoo Oryan |
| author_facet | Maryam Rahimi Tesiye Farhad Valizadegan Shahrbanoo Oryan |
| author_sort | Maryam Rahimi Tesiye |
| collection | DOAJ |
| description | Background and Aim: Working memory is a dynamic neural system for temporarily maintaining and processing of information. Prefrontal cortex (PFC) is the main processing center of Working memory by using different neurotransmitter systems communicate with other brain structures such as Basolateral Amygdala (BLA). In this study, we investigated the role of Opioidergic system in medial PFC and Dopaminergic system of BLA nucleus in working memory based on RAM test.
Materials and Methods: In this study, The male Wistar rats were used. Rats were cannulated with stereotaxic surgery in mPFC and BLA sites. After a recovery period, they were microinjected. Parameters such as working and reference memory errors were calculated with DSWS protocol.
Ethical Considerations: This study with research ethics code IR.UMZ.REC.1397.23 has been approved by Bioethics Committee at Mazandaran University, Iran.
Findings: High doses of Morphine (2 µg/rat) intra mPFC and Chloropromazine (2 µg/rat) intra BLA have improving effects on working and reference memory (p≤0.05). Low (0.005 µg/rat) and high dose (0.5 µg/rat) of Apomorphine had improving {(p≤0.05), (p≤0.01)} and the moderate dose (0.05 µg/rat) of it had decreasing effect on working and reference memory (p≤0.01). Microinjection of Morphine (0.5 µg/rat) with triple doses of Chloropromazine had no significant change on working and reference memory errors. Interaction of Morphine (0.5 µg/rat) with different doses of Apomorphine could change Apomorphine different effects. Coadministration of different doses of Apomorphine with effective dose of Chloropromazine (2 µg/rat) and Morphine (2 µg/rat) decreased the working and reference memory errors.
Conclusion: Our findings showed that in processing of working and reference memory, opioidergic system in mPFC and dopaminergic system in BLA, are interacting reciprocally. |
| first_indexed | 2024-12-17T12:09:52Z |
| format | Article |
| id | doaj.art-e83378d93acb45e0a55c50984b1fbc10 |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-12-17T12:09:52Z |
| publishDate | 2019-04-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-e83378d93acb45e0a55c50984b1fbc102022-12-21T21:49:28ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2019-04-012217384Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working MemoryMaryam Rahimi Tesiye 0Farhad Valizadegan1Shahrbanoo Oryan2Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.Department of Animal Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.Background and Aim: Working memory is a dynamic neural system for temporarily maintaining and processing of information. Prefrontal cortex (PFC) is the main processing center of Working memory by using different neurotransmitter systems communicate with other brain structures such as Basolateral Amygdala (BLA). In this study, we investigated the role of Opioidergic system in medial PFC and Dopaminergic system of BLA nucleus in working memory based on RAM test. Materials and Methods: In this study, The male Wistar rats were used. Rats were cannulated with stereotaxic surgery in mPFC and BLA sites. After a recovery period, they were microinjected. Parameters such as working and reference memory errors were calculated with DSWS protocol. Ethical Considerations: This study with research ethics code IR.UMZ.REC.1397.23 has been approved by Bioethics Committee at Mazandaran University, Iran. Findings: High doses of Morphine (2 µg/rat) intra mPFC and Chloropromazine (2 µg/rat) intra BLA have improving effects on working and reference memory (p≤0.05). Low (0.005 µg/rat) and high dose (0.5 µg/rat) of Apomorphine had improving {(p≤0.05), (p≤0.01)} and the moderate dose (0.05 µg/rat) of it had decreasing effect on working and reference memory (p≤0.01). Microinjection of Morphine (0.5 µg/rat) with triple doses of Chloropromazine had no significant change on working and reference memory errors. Interaction of Morphine (0.5 µg/rat) with different doses of Apomorphine could change Apomorphine different effects. Coadministration of different doses of Apomorphine with effective dose of Chloropromazine (2 µg/rat) and Morphine (2 µg/rat) decreased the working and reference memory errors. Conclusion: Our findings showed that in processing of working and reference memory, opioidergic system in mPFC and dopaminergic system in BLA, are interacting reciprocally.http://jams.arakmu.ac.ir/article-1-5858-en.htmlApomorphineBasolateral AmygdalaChloropromazineMorphinePrefrontal cortexWorking memory |
| spellingShingle | Maryam Rahimi Tesiye Farhad Valizadegan Shahrbanoo Oryan Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Apomorphine Basolateral Amygdala Chloropromazine Morphine Prefrontal cortex Working memory |
| title | Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory |
| title_full | Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory |
| title_fullStr | Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory |
| title_full_unstemmed | Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory |
| title_short | Interaction between Effects of Opioidergic System of Prefrontal Cortex and Dopaminergic System of Basolateral Amygdala in Working Memory |
| title_sort | interaction between effects of opioidergic system of prefrontal cortex and dopaminergic system of basolateral amygdala in working memory |
| topic | Apomorphine Basolateral Amygdala Chloropromazine Morphine Prefrontal cortex Working memory |
| url | http://jams.arakmu.ac.ir/article-1-5858-en.html |
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