Computational Modeling Analysis of Kinetics of Fumarate Reductase Activity and ROS Production during Reverse Electron Transfer in Mitochondrial Respiratory Complex II

Computational Modeling Analysis of Kinetics of Fumarate Reductase Activity and ROS Production during Reverse Electron Transfer in Mitochondrial Respiratory Complex II

Reverse electron transfer in mitochondrial complex II (CII) plays an important role in hypoxia/anoxia, in particular, in ischemia, when the blood supply to an organ is disrupted and oxygen is not available. A computational model of CII was developed in this work to facilitate the quantitative analys...

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Bibliographic Details
Main Authors: Nikolay I. Markevich, Lubov N. Markevich
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
succinate dehydrogenase (SDH)
a tunnel diode behavior
fumarate reduction
complex II
reactive oxygen species (ROS)
computational model
Online Access:https://www.mdpi.com/1422-0067/24/9/8291

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