Differentiation between benign and metastatic cervical lymph nodes using ultrasound
Purpose: The oral cavity is the most common site for squamous cell carcinoma, which has a distinct predilection for lymphatic spread before distant systemic metastasis. The cervical lymph node status is a very important consideration in the assessment of squamous cell carcinoma. Ultrasound is a noni...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2019;volume=11;issue=6;spage=338;epage=346;aulast=Jayapal |
| _version_ | 1819097904729554944 |
|---|---|
| author | Namitha Jayapal Shashi Kiran Mohan Ram Vidya Sreenivasa Murthy Sulphi A Basheer Shaheen V Shamsuddin Anas Bismillah Khan |
| author_facet | Namitha Jayapal Shashi Kiran Mohan Ram Vidya Sreenivasa Murthy Sulphi A Basheer Shaheen V Shamsuddin Anas Bismillah Khan |
| author_sort | Namitha Jayapal |
| collection | DOAJ |
| description | Purpose: The oral cavity is the most common site for squamous cell carcinoma, which has a distinct predilection for lymphatic spread before distant systemic metastasis. The cervical lymph node status is a very important consideration in the assessment of squamous cell carcinoma. Ultrasound is a noninvasive and inexpensive technique that can be used to differentiate between the benign and metastatic nodes. So the aim of this study was to evaluate reliability of ultrasound for such differentiation and to correlate them with histopathological finding. Materials and Methods: A total of 200 lymph nodes from 38 patients histopathologically proven for oral squamous cell carcinoma who underwent surgical neck dissection were considered. The patients underwent ultrasound examination of cervical lymph nodes prior to surgical neck dissection. The lymph nodes were differentiated into benign and metastatic based on the assessment of size, shape, shortest diameter/longest diameter (S/L ratio), margin, and internal architecture, and also the internal echo structure of the lymph nodes and histopathological findings were analyzed. Results: On correlation of ultrasonographic diagnosis with histopathological evaluation for metastatic lymph nodes, the overall accuracy of ultrasonographic analyses was 77.83%, and the sonographic criterion of irregular margin showed the highest predictability followed by the size. The correlation of internal echo structure with histopathological findings was highly variable. Conclusion: The ultrasound parameters such as size, shape, margin, S/L ratio, and internal echo structure might assist in differentiation between benign and metastatic lymph nodes. Combining these findings should raise the accuracy, as each sonographic parameter has some limitation as a sole criterion. |
| first_indexed | 2024-12-22T00:22:30Z |
| format | Article |
| id | doaj.art-e83a09479ca946a0ae6bd8abd6a1d701 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-12-22T00:22:30Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-e83a09479ca946a0ae6bd8abd6a1d7012022-12-21T18:45:08ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062019-01-0111633834610.4103/JPBS.JPBS_26_19Differentiation between benign and metastatic cervical lymph nodes using ultrasoundNamitha JayapalShashi Kiran Mohan RamVidya Sreenivasa MurthySulphi A BasheerShaheen V ShamsuddinAnas Bismillah KhanPurpose: The oral cavity is the most common site for squamous cell carcinoma, which has a distinct predilection for lymphatic spread before distant systemic metastasis. The cervical lymph node status is a very important consideration in the assessment of squamous cell carcinoma. Ultrasound is a noninvasive and inexpensive technique that can be used to differentiate between the benign and metastatic nodes. So the aim of this study was to evaluate reliability of ultrasound for such differentiation and to correlate them with histopathological finding. Materials and Methods: A total of 200 lymph nodes from 38 patients histopathologically proven for oral squamous cell carcinoma who underwent surgical neck dissection were considered. The patients underwent ultrasound examination of cervical lymph nodes prior to surgical neck dissection. The lymph nodes were differentiated into benign and metastatic based on the assessment of size, shape, shortest diameter/longest diameter (S/L ratio), margin, and internal architecture, and also the internal echo structure of the lymph nodes and histopathological findings were analyzed. Results: On correlation of ultrasonographic diagnosis with histopathological evaluation for metastatic lymph nodes, the overall accuracy of ultrasonographic analyses was 77.83%, and the sonographic criterion of irregular margin showed the highest predictability followed by the size. The correlation of internal echo structure with histopathological findings was highly variable. Conclusion: The ultrasound parameters such as size, shape, margin, S/L ratio, and internal echo structure might assist in differentiation between benign and metastatic lymph nodes. Combining these findings should raise the accuracy, as each sonographic parameter has some limitation as a sole criterion.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2019;volume=11;issue=6;spage=338;epage=346;aulast=JayapalHistopathologylymph nodesoral cancerultrasonography |
| spellingShingle | Namitha Jayapal Shashi Kiran Mohan Ram Vidya Sreenivasa Murthy Sulphi A Basheer Shaheen V Shamsuddin Anas Bismillah Khan Differentiation between benign and metastatic cervical lymph nodes using ultrasound Journal of Pharmacy and Bioallied Sciences Histopathology lymph nodes oral cancer ultrasonography |
| title | Differentiation between benign and metastatic cervical lymph nodes using ultrasound |
| title_full | Differentiation between benign and metastatic cervical lymph nodes using ultrasound |
| title_fullStr | Differentiation between benign and metastatic cervical lymph nodes using ultrasound |
| title_full_unstemmed | Differentiation between benign and metastatic cervical lymph nodes using ultrasound |
| title_short | Differentiation between benign and metastatic cervical lymph nodes using ultrasound |
| title_sort | differentiation between benign and metastatic cervical lymph nodes using ultrasound |
| topic | Histopathology lymph nodes oral cancer ultrasonography |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2019;volume=11;issue=6;spage=338;epage=346;aulast=Jayapal |
| work_keys_str_mv | AT namithajayapal differentiationbetweenbenignandmetastaticcervicallymphnodesusingultrasound AT shashikiranmohanram differentiationbetweenbenignandmetastaticcervicallymphnodesusingultrasound AT vidyasreenivasamurthy differentiationbetweenbenignandmetastaticcervicallymphnodesusingultrasound AT sulphiabasheer differentiationbetweenbenignandmetastaticcervicallymphnodesusingultrasound AT shaheenvshamsuddin differentiationbetweenbenignandmetastaticcervicallymphnodesusingultrasound AT anasbismillahkhan differentiationbetweenbenignandmetastaticcervicallymphnodesusingultrasound |