MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica.
Chronic infection with Schistosoma japonicum is an important cause of hepatic fibrosis (HF). Human 9q33.3 is one of the most important loci for stress-related diseases. We examined the potential associations of 43 single-nucleotide polymorphisms (SNPs) with S. japonicum infection and HF in epidemic...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4143368?pdf=render |
| _version_ | 1818846524005679104 |
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| author | Xiao Zhu Jinfang Zhang Wenguo Fan Yunguo Gong Jianhua Yan Zhidong Yuan Lang Wu Hongjing Cui Haiqing Luo Qingming Kong Li Tang Shuilong Leng Yufeng Liao Weiming Fu Qin Xiao Dongpei Li |
| author_facet | Xiao Zhu Jinfang Zhang Wenguo Fan Yunguo Gong Jianhua Yan Zhidong Yuan Lang Wu Hongjing Cui Haiqing Luo Qingming Kong Li Tang Shuilong Leng Yufeng Liao Weiming Fu Qin Xiao Dongpei Li |
| author_sort | Xiao Zhu |
| collection | DOAJ |
| description | Chronic infection with Schistosoma japonicum is an important cause of hepatic fibrosis (HF). Human 9q33.3 is one of the most important loci for stress-related diseases. We examined the potential associations of 43 single-nucleotide polymorphisms (SNPs) with S. japonicum infection and HF in epidemic region in China. We identified a SNP (rs10118570 GG in mitogen-activated protein kinase associated protein 1, MAPKAP1) contributes to anti-infection (adjusted OR = 0.35) and anti-fibrogenesis (adjusted RR = 0.44) in the discovery study. Replicative and combined studies showed consistent protective quality for this genotype (replicative: adjusted OR = 0.37 for anti-infection, and adjusted RR = 0.40 for anti-fibrogenesis; Combined: adjusted OR = 0.45 for anti-infection, and adjusted RR = 0.42 for anti-fibrogenesis). Univariate and multivariate analysis in the discovery, replicative and combined studies, suggested that durations (years), splenomegaly, serum ALB and rs10118570 were independent predictors influencing the fibrogenesis. The analysis of gene-gene interaction showed rs10118570 functions independently. We conclude that MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica. And rs10118570 may be a potential biomarker and target for the treatment of this life-threatening ancient disease. |
| first_indexed | 2024-12-19T05:46:55Z |
| format | Article |
| id | doaj.art-e83b8e071a4d4986ae278c4dd2996735 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T05:46:55Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e83b8e071a4d4986ae278c4dd29967352022-12-21T20:33:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0198e10599510.1371/journal.pone.0105995MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica.Xiao ZhuJinfang ZhangWenguo FanYunguo GongJianhua YanZhidong YuanLang WuHongjing CuiHaiqing LuoQingming KongLi TangShuilong LengYufeng LiaoWeiming FuQin XiaoDongpei LiChronic infection with Schistosoma japonicum is an important cause of hepatic fibrosis (HF). Human 9q33.3 is one of the most important loci for stress-related diseases. We examined the potential associations of 43 single-nucleotide polymorphisms (SNPs) with S. japonicum infection and HF in epidemic region in China. We identified a SNP (rs10118570 GG in mitogen-activated protein kinase associated protein 1, MAPKAP1) contributes to anti-infection (adjusted OR = 0.35) and anti-fibrogenesis (adjusted RR = 0.44) in the discovery study. Replicative and combined studies showed consistent protective quality for this genotype (replicative: adjusted OR = 0.37 for anti-infection, and adjusted RR = 0.40 for anti-fibrogenesis; Combined: adjusted OR = 0.45 for anti-infection, and adjusted RR = 0.42 for anti-fibrogenesis). Univariate and multivariate analysis in the discovery, replicative and combined studies, suggested that durations (years), splenomegaly, serum ALB and rs10118570 were independent predictors influencing the fibrogenesis. The analysis of gene-gene interaction showed rs10118570 functions independently. We conclude that MAPKAP1 may represent a novel anti-infection and anti-fibrogenesis genomic locus in chronic schistosomiasis japonica. And rs10118570 may be a potential biomarker and target for the treatment of this life-threatening ancient disease.http://europepmc.org/articles/PMC4143368?pdf=render |
| spellingShingle | Xiao Zhu Jinfang Zhang Wenguo Fan Yunguo Gong Jianhua Yan Zhidong Yuan Lang Wu Hongjing Cui Haiqing Luo Qingming Kong Li Tang Shuilong Leng Yufeng Liao Weiming Fu Qin Xiao Dongpei Li MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica. PLoS ONE |
| title | MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica. |
| title_full | MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica. |
| title_fullStr | MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica. |
| title_full_unstemmed | MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica. |
| title_short | MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica. |
| title_sort | mapkap1 rs10118570 polymorphism is associated with anti infection and anti hepatic fibrogenesis in schistosomiasis japonica |
| url | http://europepmc.org/articles/PMC4143368?pdf=render |
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